Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Azole antifungal"”.
-
Transcriptional Regulation of Azole Antifungal Resistance in Candida albicans
… virus (HIV). OPC is usually treated with azole antifungals, a class of antifungals that target ergosterol biosynthesis, at low doses over long periods of time. This course of treatment allows for the development of azole resistance.</p> <p>Two major mechanisms of azole resistance exist in …
-
Transcriptional Regulation of Azole Antifungal Resistance and Tolerance in Candida Glabrata
<p>Azole antifungal resistance has emerged as a significant problem in the management of infections caused by fungi including <em>Candida</em> species. In recent years, <em>Candida glabrata</em> has become the second most common cause of mucosal and invasive fungal infections in humans second to …
-
Repetitive Sequences Drive Rapid Adaptation in Candida albicans
… (LOH) confer increased virulence and antifungal drug resistance, yet the mechanisms and dynamics that drive these types of genome plasticity are not completely understood. In this dissertation, we build on foundational studies that identified recurrent, adaptive CNVs that occurred …
-
The Effects of Ketoconazole on the Oxidation of Low Density Lipoproteins by Bovine Aortic Smooth Muscle Cells
… of atherosclerosis. This work shows that the azole antifungal drug ketoconazole when added to the culture medium of BASMC inhibits LDL oxidation. Confluent BASMC were fed 1 ml of F- 12/DMEM containing LDL (320 ug protein). The cells over a 24 hour period caused a 2x increase in LDL oxidation …
-
Targeting tGLI1-positive Breast Cancer with Ketoconazole
… chemical screen approach, we found that ketoconazole, an FDA-approved azole antifungal, was able to kill tGLI1-expressing cancer cells with increased efficacy against the CSC subpopulation. Additionally, ketoconazole selectively inhibited the progression of tGLI1-positive BCBM in vivo. …
-
Phenotypic and molecular antifungal susceptibility testing of yeast isolates from Pretoria
Antifungal drug resistance is a growing problem. Several mechanisms contribute to the development of resistance to antifungal agents. In South Africa, little is known about the antifungal susceptibility of local yeast isolates. The aim of this study was therefore to determine the antifungal …
-
ERG11-Mediated Azole Resistance in Candida albicans
… with fungal infections, the emergence of antifungal resistant clinical isolates creates significant problem in regards to antifungal prophylaxis and empirical treatment strategies. Antifungal resistance is associated with high mortality rates and hefty medical costs. The azole-antifungal …
-
Signal Transduction and Transcriptional Regulation Pathways Essential for Azole Resistance in Candida albicans
… with human immunodeficiency virus (HIV). The azole antifungals (such as fluconazole) are the most widely used and important ergosterol biosynthesis inhibitors (EBIs) for the treatment of Candida infections, including OPC. However, the azoles are fungistatic against C. albicans and therefore …
-
Targeting CYP5122A1 and CYP51 for the Inhibition of Ergosterol Biosynthesis in Trypanosomatids
… helps to determine the antileishmanial effect of antifungal azoles in vitro. Dual inhibitors of CYP51 and CYP5122A1, e.g., clotrimazole and posaconazole, possess superior antileishmanial activity against L. donovani promastigotes whereas CYP51-selective inhibitors, e.g., fluconazole and …