Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"Azole"”.
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ERG11-Mediated Azole Resistance in Candida albicans
… mortality rates and hefty medical costs. The azole-antifungal class has been the “work horse” of antifungal pharmacotherapy for the past 20 years defined by its efficacy against <em>Candida</em> species and paucity of side effects. As the only oral option available for systemic antifungal …
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Transcriptional Regulation of Azole Antifungal Resistance in Candida albicans
… virus (HIV). OPC is usually treated with azole antifungals, a class of antifungals that target ergosterol biosynthesis, at low doses over long periods of time. This course of treatment allows for the development of azole resistance.</p> <p>Two major mechanisms of azole resistance exist in …
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New Challenges in Azole Resistance Selection in Aspergillus fumigatus
Contains fulltext : 327953.pdf (Publisher’s version ) (Closed access)
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Toxicological evaluation of azole fungicides in agriculture and food chemistry
Azole sind wichtige Chemikalien, die als Fungizide in der Landwirtschaft und der Medizin eingesetzt werden. Auch als Zytostatika in der Humanmedizin finden sie Anwendung. Die fungizide Wirkung beruht auf der Hemmung der Lanosterol-14α-Demethylase (CYP51), die die Demethylierung von Lanosterol zum …
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Phase Control and Transformations of Azole-Based Metal Organic Framework Composites
Zinc-azole-based metal organic frameworks (MOFs) have been demonstrated to exist in a wide variety of structural states, with applications in different fields such as gas separation. In this dissertation, we explore the phase control and dynamics of zinc-azolebased MOFs in crystalline, liquid, and …
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Transcriptional Regulation of Azole Antifungal Resistance and Tolerance in Candida Glabrata
<p>Azole antifungal resistance has emerged as a significant problem in the management of infections caused by fungi including <em>Candida</em> species. In recent years, <em>Candida glabrata</em> has become the second most common cause of mucosal and invasive fungal infections in humans second to …
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Novel Determinants That Influence Azole Susceptibility in Candida glabrata and Candida albicans
… class of currently available antifungals - the azoles.</p> <p>Other available antifungals have associated toxicities, are not available as oral dosage forms or are cost prohibitive. As multidrug resistant <em>C. glabrata </em>have been reported, the need to find ways to overcome resistance to …
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An Investigation into Clinically Relevant Determinants of Azole Resistance in Candida albicans
… healthcare system. Over the last 30 years, the azole antifungals have been a mainstay of antifungal therapy, being effective in a wide variety of fungal infections and serving as the primary oral treatment option. However, increased use, inappropriate dosing, and prolonged treatments have given …
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Signal Transduction and Transcriptional Regulation Pathways Essential for Azole Resistance in Candida albicans
… with human immunodeficiency virus (HIV). The azole antifungals (such as fluconazole) are the most widely used and important ergosterol biosynthesis inhibitors (EBIs) for the treatment of Candida infections, including OPC. However, the azoles are fungistatic against C. albicans and therefore …
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The role of adaptive mechanisms in the development of azole resistance in Aspergillus fumigatus
Contains fulltext : 293024.pdf (Publisher’s version ) (Open Access)
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Targeting ALS: A Multi-Cellular Study on the Potential Therapeutic Role of Azole-Based Compounds
<p>Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease, is a progressive neurodegenerative disorder that leads to the degeneration of motor neurons, which control voluntary muscle movements such as eating, speaking, and breathing. As these neurons are damaged, voluntary movement …
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Comparative efficacy of azole compounds targeting sterol 14-demethylase against multiple isolates of Acanthamoeba castellanii and polyphaga
… an attractive drug target in Acanthamoeba. Azoles are an antifungal medication that target the cytochrome P450 enzyme sterol 14-demethylase, this enzyme is essential in the ergosterol pathway and its inhibition results in the loss of membrane stability and cell death. In this study five …
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Endosomal Trafficking as a Determinant of Antifungal Tolerance in the Pathogenic Fungus Candida albicans
… of fungal cell membranes. These include the azole antifungals, which block ergosterol biosynthesis by inhibiting lanosterol demethylase (Erg11p). The resulting depletion of cellular ergosterol and the accumulation of ‘toxic’ sterol intermediates are both thought to cause plasma membrane …
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Revealing the molecular details of azoline formation in ribosomal natural product biosynthesis
The thiazole/oxazole-modified microcins (TOMMs) are a recently grouped class of ribosomally synthesized and posttranslationally modified peptides. Encoded by many bacteria and archaea, these natural products occupy a large chemical and functional space and are linked by the presence of the …
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Phenotypic and molecular antifungal susceptibility testing of yeast isolates from Pretoria
… isolates was determined by the Etest for three azole antifungals (fluconazole, posaconazole and voriconazole), amphotericin B and caspofungin. Clinical breakpoint susceptibility was determined according to the CLSI clinical breakpoint reference methods. Polymerase chain reaction was performed on …
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Repetitive Sequences Drive Rapid Adaptation in Candida albicans
… during the acute stages of adaptation to azole antifungal drugs. Additionally, we describe the occurrence of complex CNVs that are associated with a decreased sensitivity to multiple azole antifungal drugs. We describe how these complex CNVs are generated via an intra- chromosomal …
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The Molecular Mechanisms of Antifungal Drug Resistance In Pathogenic Fungi
… mostly in immune-compromised individuals. Azoles are the most common antifungals used in treating these infections. The most significant mechanisms of azole resistance include alterations or overexpression of the target enzyme, and overexpression of at least three distinct efflux pumps. …
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Diagnostic characterization of Malassezia pachydermatis isolates from canine otitis externa
… that treating M. pachydermatis OE with miconazole was no longer successful in a number of cases. This finding raised the question of whether the treatment failure was due to intrinsic resistance of a cryptic species or if azole resistance was emerging in M. pachydermatis clinical isolates. To …
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Developing novel drug combinations for treatment of invasive fungal infections
… are restricted to three classes of antifungals: Azoles, polyenes, and echinocandins. The emergence of new fungal species, especially C. auris, marked by high resistance profiles and increased mortality rates (30-60%), has further exacerbated the limitations in its therapeutic options. This …
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