Global ETD Search
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Showing 1 to 2 of 2 for “"Aziridinium ions"”.
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New applications of Imidazotetrazinone prodrugs. Synthesis and mechanistic investigation of novel imidazotetrazinones as prodrugs of aziridines and as traceless carriers for drug delivery to the central nervous system.
… possess features in their structures to release aziridinium ions upon ring opening. Unstable 2-aminoethylisocyanates were required in this preparation, which were synthesized with BOC-protection of the amino group to counteract the reactivity of the amine towards the isocyanate group in the case …
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Nitrosative guanosine deamination : pyrimidine ring opening implications of effects in homogeneous solution as well as anisotropic environments
… are known to cause two types of chemical reactions with DNA bases, deamination and interstrand cross linking involving the nitrosation of exocyclic amino group of guanine, adenine and cytosine. The ingestion or inhalation of nitrosating reagents (NO[subscript x][superscript -] ) contained in …