Global ETD Search
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Showing 1 to 13 of 13 for “"Azathioprine"”.
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Risk of malignancy in patients with inflammatory bowel disease treated with Azathioprine or 6-mercaptopurine : the Cape Town experience
The benefits of the use of Azathioprine (AZA) and its metabolite 6-mercaptopurine (6-MP) in the treatment of Inflammatory Bowel Disease (IBD) are well established. However, concern regarding the long-term use of these agents in the induction of certain malignancies particularlty lymphoma and skin …
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Identifying the molecular basis for treatment resistance in a subset of myasthenia gravis patients of African ancestory
… an additional steroid-sparing agent, such as azathioprine, cyclosporin A or methotrexate. We hypothesised that MG patients with the C>G SNP when treated with immunosuppressant drugs, may have lower DAF protein levels contributing to increased susceptibility to autologous complement-mediated …
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Η επίδραση της χρόνιας χορήγησης αζαθειοπρίνης στην οστική πλήρωση του μετεξακτικού φατνίου: πειραματική μελέτη σε λευκούς επίμυς
… was to study the pharmacologic, action of azathioprine on the bone healing of the postextraction socket. The material of this study composed of 79 male rats from ourproduction. At the beginning of the experiment the rats weighed 121-125g and were 45-50 days old. They were separated in two …
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Investigating immunosuppression as a disease modifying strategy in Parkinson's disease
… 2 double-blind randomised controlled trial of azathioprine (“AZA-PD”), an immunosuppressant medication, to investigate whether suppressing the peripheral immune system has a disease-modifying effect in PD. At the time of writing, I am still blinded to treatment allocation, therefore this thesis …
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Lymphocytopenia in patients with inflammatory bowel disease on immunosuppressive medications
Azathioprine and 6-mercaptopurine (AZA/6MP) are effective immunosuppressives commonly used for the treatment of inflammatory bowel disease (IBD). The mercaptopurine metabolites, 6-thioguanine (6TG) and 6-methylmercaptopurine ribonucleotides (6MMP), have been suggested as surrogate markers of the …
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Outcomes of renal transplantation in patients with lupus nephritis: a single centre study in Cape Town
… (46.7%) with combination of cyclosporine and azathioprine; in 2/15 (13.3%) with tacrolimus and azathioprine and in 6/15 (40.0%) with Tacrolimus and MMF. All patients received corticosteroids. Recurrence of LN was seen in one patient (6.7%) who developed class V LN. Graft rejection was …
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Pharmacogenetic markers of response to drugs used in the management of Inflammatory Bowel Disease
… 14 bp ins/del polymorphism was correlated with azathioprine (AZA) response in 97 IBD patients. The IL-10 -1082A>G, -819C>T and -592C>A promoter SNPs on chromosome 1 were examined for an influence on the effect of the 14bp ins/del polymorphism in this group. The 14bp ins/del polymorphism was …
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Indications and outcomes of abdominal surgery in patients with Crohn s Disease attending a tertiary hospital: a single centre study
… 22% of patients were on steroids, 47% on azathioprine and 10% on biologics. The commonest indication for surgery was small bowel obstruction (37.6%), followed by fistulizing disease (18.8%). Sixty one percent of patients had one surgery, with a quarter needing more than two surgeries in …
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Chronic hepatitis at Groote Schuur Hospital: 1978-1996 : a literature review of the syndrome, its clinical spectrum and management at Groote Schuur Hospital
… clinical and biochemical response to steroid and azathioprine therapy that is indistinguishable from that seen in classical autoimmune hepatitis cases on similar treatment. This study is retrospective and covers the period 1978 - 1996. The patients studied are those with chronic hepatitis as …
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A Study of Craniofacial Growth in Infant Heart Transplant Recipients Receiving Cyclosporine
… immunosuppression agent was cyclosporine with azathioprine or methotrexate. Rescue therapy for graft rejection consisted of glucocorticoid and/or polyclonal antibody therapy. None of the subjects received the immunosupressant tacrolimus (FK506). Using lateral cephalometric radiography, seven …
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A Continued Investigation of Craniofacial Growth in Infant Heart Transplant Recipients Receiving Cyclosporine
… immunosuppression agent was cyclosporine with azathioprine or methotrexate. Rescue therapy for graft rejection consisted of glucocorticoid and/or polyclonal antibody therapy.</p> <p>None of the subjects received the immunosuppressant tacrolimus (FK506). Using lateral cephalometric radiography, …
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A Continued Investigation of Craniofacial Growth in Infant Heart Transplant Recipients Receiving Cyclosporine
… immunosuppression agent was cyclosporine with azathioprine or methotrexate. Using lateral cephalometric radiography, seven skeletal angular measurements (SNA, SNB, ANB, GoGn-SN, NA-Pog, ArGoMe, Npogvn AB) were examined and compared to contemporary cephalometric norms. Hand/wrist radiographs …