Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Azaindole"”.
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Synthesis of aza-tryptophan derivatives.
The preparation of racemic 7-azatryptophan from 7-azaindole has been accomplished. The aldol condensation of 1-tert-butoxycarbonyl-3-formyl-7-azaindole with methyl hippurate installed the carbon framework necessary for the intended product. Subsequent deoxygenation and deprotection of the indole, …
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Transition Metal-Catalyzed Preparation and Functionalization of Nitrogen-Containing Heterocycles
… in extending the direct arylation technique to azaindole compounds. Ultimately, this research led to two different palladium-based catalyst systems - one that performed the cross-coupling event on the azine ring of azaindole, and one that arylated the azole ring. In the second section, we extend …
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Spectroscopic and thermodynamic studies of supercritical fluid solutions containing a cosolvent
… molecules (2-naphthol, 5-cyano-2-naphthol, and 7-azaindole) in the supercritical fluids carbon dioxide, ethane, ethylene, and fluoroform, with water, methanol, and ethanol as cosolvents. In liquid solutions, these probes exhibit well characterized spectral responses to an organized, hydrogen …
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Oxidative addition of N-H and O-H bonds to iridium: developing active catalysts for N-H and O-H additions to unsaturates
… N-H bond of pyrrole, indole, 3-methylindole, 7-azaindole, carbazole and aniline to [Ir(COD)(PMe₃)₃]CI (<b>1a</b>) (COD = 1,5-cyclooctadiene) produces merIr( NR₂)H(PMe₃)₃CI (<b>2a-f</b>) complexes. That these amines were bound to iridium through an Ir-N bond was established by ¹H, ³¹P and ¹³C NMR …
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Synthesis and evaluation of novel azaindolocarbazole derivatives as cancer chemotherapeutics
This thesis details the design and implementation of novel chemical routes towards a series of highly propitious 7-azaindolyl derivatives of the indolocarbazole (ICZ) and bisindolylmaleimide (BIM) families, with subsequent evaluation for use as cancer chemotherapeutic agents. A robust synthetic …