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Showing 1 to 12 of 12 for “"Azaheterocycles"”.
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A Diversity-Oriented Synthesis Approach to Functionalized Azaheterocycles using Cyclic Alpha-Halo Eneformamides
Functionalized piperidines, azepanes, azamacrocycles, morpholines, and thiomorpholines are common structural motifs found in a wide range of pharmaceuticals such as carmegliptine, levofloxacin, thioridazine, claviciptic acid, and azithomycin. As a result, there is a strong desire to construct …
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Total synthesis and study of myrmicarin alkaloids
… palladium catalyzed N-vinylation of azaheterocycles with vinyl triflates is described. Cyclic and acyclic vinyl triflates along with non-nucleophilic azaheterocycles were found to be substrates for this palladium catalyzed synthesis of N-vinyl pyrrole and indole derivatives. III. …
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Methodology for the syntheses of pharmaceutically significant functional groups
… herein: the selective benzylic fluorinations of azaheterocycles via a nitrogen-fluorine halogen bond, the synthesis of sulfoxides and sulfenamides from highly reactive and unstable chloramine in continuous-flow, and partial translation of the process route to enantiopure (S)-naproxen from batch …
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Novel metal- and main group-catalyzed methods for modulating molecular oxygenation
… implemented to oxidize the benzylic positions of azaheterocycles. Coordination of a metal catalyst to the nitrogen lone pair is thought to induce weakening of proximal C-H bonds such that a radical catalyst with tunable chemoselectivity breaks this weakened bond. In the presence of an oxygen …
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Development of transitional metal-catalyzed reactions for organic synthesis
… the presence of both lactams as well as azaheterocycles in the [beta]-position of various enoates. This has led to the asymmetric synthesis of a number of interesting [5- amino acid derivatives. Chapter 4. A copper-catalyzed conjugate reduction reaction that allows for a variety of …
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Organophosphorus-Catalyzed Reductive Functionalization of Nitrocompounds via P(III)/P(V) Redox Couple
… sequence, yielding a variety N-functionalized azaheterocycles (oxindoles, indoles, quinoxalinediones, and benzimidazoles). Besides boronic acids, anilines were also introduced as an exogenous coupling partner for novel cross-selective intermolecular N–N bond forming reactivity in the formation …
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Direct synthesis of pyridine and pyrimidine derivatives
… and readily converted to the corresponding azaheterocycles. II. Single-Step Synthesis of Pyrimidine Derivatives. The single-step conversion of various N-vinyl and N-aryl amides to the corresponding pyrimidine and quinazoline derivatives, respectively, is described. The process involves amide …
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Stereoselective monoalkyl diazene synthesis for mild reductive transformations : direct synthesis of densely substituted pyridines and pyrimidines
… in this chemistry provides versatile azaheterocycles poised for further derivatization. The synthesis of a variety of previously inaccessible C2- and C4- pyrimidine derivatives using this methodology is noteworthy.
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Synthesis of 4-(trifluoromethyl)azetidin-2-one building blocks and their transformation into novel CF3-substituted amines and heterocyclic systems
… diverse set of functionalized CF3-amines and CF3-azaheterocycles was investigated. In particular, 3-benzyloxy-4-trifluoromethyl-β-lactams were conveniently synthesized as a first new class of building blocks. The aptitude of these systems with respect to ring-opening reactions was explored to …
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I The synthesis and coordination chemistry of novel 1,1,1-tris(aminomethyl)ethane (TAME) derived ligands and their use as size selective fluorescent zinc(II) sensors II The synthesis of strongly and weakly binding ligands with nitrogen, oxygen, and sulfur-donor groups to be used as receptors in fluorescent ratiometric indicators for transition metal ions
… ligand TAMEpyr were exchanged with a host of azaheterocycles affording a collection of novel TAME derived chelators.</p><p>The Ni(II)-template chemistry developed to prepare the novel chelator TAMEpyr was exploited in the preparation of novel Zn(II)-selective fluorescent sensors. The molecules …