Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"Axonal transport"”.
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The role of Huntingtin in fast axonal transport
… To evaluate the putative function of Htt in fast axonal transport, we characterized the co-localization of the Drosophila Htt homolog tagged with mRFP (dHtt-RFP), and the alterations in axonal transport kinetics associated with a dhtt null. We find that dHtt co-localizes with a subset of cargos …
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Effect of nitric oxide and inflammatory mediators on axonal transport
… der Aktivierung von Microgliazellen auf den Transport von Organellen, Vorläufervesikel und Mitochondrien in Axonen untersucht. Mikrogliazellen sind mitverantwortlich für die Immunreaktionen im Gehirn und setzen dabei Stickstoffmonooxid und entzündliche Mediatoren frei Durch Kombination von …
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Analysis of axonal transport and molecular chaperones during neurodegeneration in drosophila
… systems in early neurodegenerative changes. Axonal transport (AT) is perturbed in several prevalent neurodegenerative diseases. The development of a Huntington’s Disease (HD) model in Drosophila melanogaster larvae is described, in which disease gene expression is directed to motor neurons …
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Axonal Transport of Glycoproteins and Glycolipids in the Goldfish Optic System
… is a convenient experimental system for studying axonal transport. Radioactive precursors are injected into the eye, and radioactivity which is transported in the axons of the retinal ganglion cells can be studied as it moves in the optic nerve and optic tract to the optic tectum, where the optic …
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Axonal transport and life cycle of mitochondria in Parkinson's disease model
… deficient animals displayed less number of axonal mitochondria without disturbing organelle motility behaviors, morphology and metabolic state. Instead, loss of Parkin produced tubular and reticular mitochondria specifically in motor neuronal cell body. In addition, unlike in immortalized …
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Molecular mechanisms of axonal transport impairment in C9orf72-associated neurodegenerative disease
… of the microtubule cytoskeleton and efficient axonal transport by the microtubule-based motors kinesin and dynein to maintain cell shape and function. Perturbation of the axonal transport machinery has been associated with various neurodegenerative diseases, including Alzheimer’s disease, and …
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Stress-activated protein kinase 1 and fast axonal transport in Huntington's disease.
Stress-activated protein kinase 1 and fast axonal transport in Huntington's disease.
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ANALYSIS OF AXONAL TRANSPORT DEFECTS IN A ZEBRAFISH MODEL FOR SPINAL MUSCULAR ATROPHY
… transcripts and an increased sensitivity to axonal transport deficiencies. The splicing factor Srsf6b and motor adaptor protein Fez1 are two candidate target proteins for SMN in these processes, respectively. I aimed to study the roles of these proteins in order to better understand the …
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Microdevices for Isolating Single Axons for the Study of Axonal Transport in Dopaminergic Neurons
<p>Axonal degeneration plays an important role in the etiology of major central nervous system: CNS) neurodegenerative disorders such as Parkinson's disease: PD) but investigations into the mechanisms underlying this important process has been limited. The goal of this dissertation was to design …
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Organellar Zn2+ Homeostasis and the Role of TRPML Channels in Neuronal Lysosome Physiology and Axonal Transport
… cargo delivery over long distances through axonal transport requires precise spatiotemporal regulation in neurons. Here we discover that lysosomal Zn<sup>2+</sup> release through TRPML1 or Zn<sup>2+</sup> influx via depolarization, can inhibit bidirectional axonal transport. Such inhibition …
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Investigating the effect of amyotrophic lateral sclerosis-associated mutant vesicle-associated membrane protein B on axonal transport
… of neurons makes them dependent upon the proper transport of protein and organelle cargoes, especially through axons (axonal transport). Indeed, disruption to axonal transport is a very early, pathological event in ALS. A proline to serine substitution at position 56 in the vesicle-associated …
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CHARACTERIZATION OF THE ROLES OF MUSCLE-SYNTHESIZED BRAIN-DERIVED NEUROTROPHIC FACTOR AND PRESYNAPTIC TYROSINE RECEPTOR KINASE B IN MOTOR NEURON AXONAL TRANSPORT
… is delivered to the cell soma via retrograde axonal transport, where it modulates gene expression. BDNF activation of TrkB is critical for the initiation of axonal transport, and this cellular process relies on the interaction of numerous adaptor proteins, including dynactin and JIP3, which …
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ROS regulation of axonal mitochondrial transport
… and survival in neurons, mitochondria are transported along axons, and accumulate in regions with high demand for their functions. Oxidative stress and abnormal mitochondrial axonal transport are associated with neurodegenerative disorders. However, we know little about the connection …
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Understanding Neuronal Autophagic Lysosomal Pathways Through Genetic and Pharmacological Perturbations
… this process. However, despite its importance to axonal lysosome retrograde transport, the role of JIP3 in axonal transport of less mature autolysosomes and autophagosomes in mammalian neurons has not yet been described. Additionally, the impact of disrupting axonal lysosomal transport on neuronal …
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Investigating The Role of Pancreatic eIF2-alpha kinase (PEK) In DLK/ Wallenda (Wnd)-mediated Neurodegeneration In Drosophila
… and sophisticated protein localization and axonal transport for protein function and cellular homeostasis. However, neuronal homeostasis is constantly challenged by various intrinsic and extrinsic stressors, and results mislocalization and aggregation of these proteins occurs, subsequently …
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Diffuse Brain Injury Triggers Ultra-Rapid Perisomatic Traumatic Axonal Injury, Wallerian Change, and Non-Specific Inflammatory Responses
… of diffuse brain injury (DBI) is diffuse axonal injury (DAI) which is responsible for the morbidity and mortality associated with this condition. DAI and its experimental counterpart traumatic axonal injury (TAI) result in scattered microscopic pathology characterized by focal impairment …
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Characterization of a Drosophila model of Huntington's disease
… non-nuclear polyQ-containing proteins and block axonal transport.
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