Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Axonal guidance"”.
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Towards Mammalian Retinal Regeneration: Cell Signaling in Re-Differentiating Mouse Müller Glia and Transcriptional Regulation of the Axonal Guidance Receptor EPHA5
… retina and the visual areas of the brain. The axonal guidance receptors EphA5 and EphA6 are expressed in gradients across the retina, and changes in their expression alter the location of retinal ganglion cell (RGC) synaptic termination zones. Therefore, new RGCs will need to express EphA5 and …
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Halting the neural progression of cancer
Neuropilin (NRP) receptors have functions in axonal guidance and neuronal patterning. Class 3 semaphorin (SEMA3) molecules act as inhibitors of NRP receptors by preventing the activation of downstream signaling pathways involved in cytoskeletal organization and migration. Tumor-associated …
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Identification and functional characterization of two patterning genes, Zic4 and Ten_m3, in topographic map formation of the visual pathway
… from early patterning cues to arrays of axonal guidance factors allowing the relative order of retinotopic axons to be preserved. Mechanisms linking patterning molecules of early development to topographic wiring and subsequent functional responses are not well understood. In this thesis, …
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Neural Development to Neurodegeneration Through the Mind of a Worm
… pathways. The EphR/ephrin pathway is crucial for axonal guidance during development. The simple organism, <em>C. elegans</em>, allow us to study the impact of EphR/ephrin genes on neuronal morphology, synapse connections, and basic behavior. In specific EphR/ephrin mutants, we see change in …
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Control of Neuronal Circuit Assembly by Gtpase Regulators
… neuronal differentiation, migration, axonal guidance, axonal and dendritic arbor growth and, eventually, synapse formation. Changes in neuronal morphology are driven by cell intrinsic programs and by instructive signals from the environment, which are transduced by transmembrane …
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Periostin-like-factor in tissue repair and remodeling
… cellular processes like adhesion, migration, axonal guidance and growth cone extension. PLF plays an important role during embryonic development, however very low levels are present in adults. PLF is up regulated in adult tissues when they are exposed to stress or insult. We have previously …
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Fabrication and Characterization of Tunable Conducting Polymer Micro- and Nano-Structures for Bioelectronics
… the known influence of chemical gradients on axonal guidance. The third project is a further refinement of the hydrogel modality into a system by which PPy:PSS can be electropolymerized in-situ along a path. Known informally as the “gel pen”, this system behaves somewhat like a conventional 3d …
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The generation and characterization of transgenic mice expressing modifiers of Rho GTPases
… well investigated how newborn neurons elaborate axonal and dendrite processes to navigate complicated pathways and travel long distances before they reach their target. Recent studies have suggested that Rho family GTP-binding proteins are important components of the signalling pathways that link …
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Manipulating soft materials to direct cell growth in multiple dimensions
… of which include chemotaxis, haptotaxis, axonal guidance and angiogenesis, has been a relevant research focus for many years. Microfabrication techniques involving soft lithography, microfluidic devices and direct-write assembly can be used to create such microenvironments. Soft …
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The role of EphrinA for the retinotopic map formation in mouse visual cortex
… such maps has been shown to depend on specific guidance molecules that are recognised by outgrowing axons. One major family of molecules implicated in axonal guidance and map formation are the ephrin ligands and their Eph receptors. These molecules have been shown to contribute to topographic …
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Transcriptional effects of predator cues in the brain of Spodoptera frugiperda (lepidoptera: noctuidae) moths exposed to bat ultrasound
… binding and other epigenetic modifications, axonal guidance and remodeling, cilia function and development, Wnt signaling, and TOR signaling. The top five significantly over-represented GO terms included chromatin binding, macromolecular complex binding, glutamate synthase activity, glutamate …
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Comparative analysis of transcriptome of fracture healing under normal and hypophosphatemic conditions
… earlier time showing activation of the WNT/SHH axonal guidance signaling suggesting potential interplay in cellular migration and differentiation. Group 3 showed a marked shift in return from a downregulated state during the first two weeks when the mice were on their restricted diets to higher …