Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Axonal Outgrowth"”.
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Sex differences in the development of the splenium of the rat corpus callosum
… MAP1b, which has been associated with axonal outgrowth, was present in the splenium at postnatal days 9 and 11, but not at day 17. This suggests that axonal outgrowth in the rat splenium ceases by the end of the second postnatal week. Embryonic NCAM was present in the splenium from …
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REPEATED BIPHASIC CONDUCTING CONDUITS FOR PERIPHERAL NERVE REPAIR
… Due to rapid scar formation which blocks nerve outgrowth, there are no treatment options for the approximately 90% of patients who have gaps greater than 3 cm. Resultantly, researchers have focused on methods to accelerate axon outgrowth. Electrical stimulation studies have accelerated axon …
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The extraction of type 1 collagen and the fabrication of multi-filament embedded hydrogels for guided nerve regeneration
… some success in pre-clinical studies to induce axonal generation, but the reconnection of axons over large distances remains the greatest challenge. Since the development of nerve conduit to facilitate general axonal regeneration, the primary focus has changed to directing the regeneration of …
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Investigating the Role of MicroRNAs in Regeneration and Axonal Pathfinding
… environment to change the direction of axonal outgrowth. MicroRNAs, which regulate mRNA translation, have recently been shown to regulate both neurite outgrowth and growth cone guidance in response to classical guidance cues during vertebrate development. However, little is known of …
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Investigation of electrospun fibrous scaffolds, locally delivered anti-inflammatory drugs, and neural stem cells for promoting nerve regeneration
… the functionalization of the fibers with the axonal outgrowth promoting protein, laminin, to further enhance regeneration. The implantation of stem cells at the. site of a spinal cord or peripheral nerve lesion has been shown to promote nerve regeneration. Preliminary work to isolate and …
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Inflammation Promotes the Processing of Glial Cell-Line Derived Neurotrophic Factor by Matrix Metalloproteinase-9 in Intestinal Smooth Muscle Cells
… in both the expression of 15 kDa GDNF and in the axonal outgrowth of myenteric neurons, compared to control. Evaluation of broad-spectrum protease inhibitors or inhibitors of metalloproteinases (MMP) showed that only inhibition of MMP-9 specifically blocked TNFα-induced axonal proliferation. The …
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The generation and characterization of transgenic mice expressing modifiers of Rho GTPases
… well investigated how newborn neurons elaborate axonal and dendrite processes to navigate complicated pathways and travel long distances before they reach their target. Recent studies have suggested that Rho family GTP-binding proteins are important components of the signalling pathways that link …
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VOLTAGE GATED SODIUM CHANNEL AND NEURONAL DIFFERENTIATION. IMPLICATIONS IN AMYOTROPHIC LATERAL SCLEROSIS PATHOGENESIS
… b1 subunits were reported to be fundamental in axonal outgrowth in mouse neuron primary culture. Moreover, our previous studies on a zebrafish model of Amyotrophic Lateral Sclerosis, that express the mutant G93R form of the superoxide dismutase 1 (SOD1) enzyme, show that alteration in the INaP …
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Identification and characterisation of novel zebrafish brain development mutants obtained by large-scale forward mutagenesis screening
… against acetylated Tubulin, which marks all axonal scaffolds, and anti-Opsin, which is a marker for photoreceptors in the pineal gland. According to their phenotype, I distributed the mutant lines into 4 phenotypic subgroups, of which the brain morphology group with 18 mutant lines was …
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Development and application of optical microscopy tools for the study of axon guidance
… method was established to examine intricate axonal structures within the highly complex physiological environment. To achieve this, expansion microscopy (ExM) was combined with light sheet fluorescence microscopy (LSFM) to visualise RGC branching *in vivo*. By tracing individual axons, this …
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Engrailed genes are cell autonomously required for the survival of the mesencephalic dopaminergic neurons
… feature of those neurons is the lack of axonal projection towards the telencephalon. We first addressed the question whether these neurons, lacking En, were dying because of their inability to project and interact with trophic clues. In our study we report that En genes are not regulating …
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Substrate stiffness tunes the neuronal response to the chemical guidance cue semaphorin3A
… of the Piezo1 agonist Yoda1 triggered axonal calcium transients in RGC axons, while Piezo1 knockdown with an antisense morpholino resulted in increased axonal outgrowth. This mechanosensitive ion channel-dependent modulation of intracellular calcium, which is a crucial second messenger …