Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Axonal Injury"”.
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Mitochondrial response to axonal injury
The failure of axonal regeneration is due to myriad reasons both cell intrinsic and extrinsic. In this thesis, I sought to investigate an intrinsic reason for regeneration failure in the CNS. Specifically, I investigated the role of axonal mitochondria in the axonal response to injury. A viral …
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Diffuse axonal injury effect on myelinating cells and axons
… evidence whether myelin degeneration in diffuse axonal injury (DAI) of the white matter is due to death of myelinating oligodendrocytes or secondary axotomy. Cortical neurons are not able to remain healthy in culture to have their axons myelinated. Dorsal root ganglion (DRG) neurons have been …
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Longitudinal Changes in Resting-State Connectivity after Traumatic Axonal Injury
… connectivity immediately after a traumatic axonal injury (TAI). This is the first longitudinal study in TAI to examine functional connectivity in the Default Mode Network (DMN) and Central Executive Network (CEN) within 48 hours after traumatic brain injury with repeat imaging 7 months …
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Experimental Modelling and Molecular Mechanisms of Wallerian Degeneration in Traumatic Axonal Injury
Traumatic brain injury (TBI) is a common event that can lead to profound consequences for the individual involved, and a considerable socio-economic cost. The initial injury event triggers a series of secondary brain injury mechanisms that lead to further mortality and contribute to morbidity. One …
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Comparison of progression of diffuse axonal injury with histology and diffusion tensor imaging
<p>Diffuse axonal injury, also known as traumatic axonal injury (TAI), is a major contributor to the pathology of traumatic brain injury. However, TAI is undetectable to conventional clinical magnetic resonance (MR) imaging techniques. Histologically, TAI is characterized by swollen axons that …
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The Relationship Between Axonal Injury, Biomarker Expression And Mechanical Response In A Rodent Head Impact Acceleration Model
… 1.4 million people sustain traumatic brain injury (TBI) each year, resulting in 235,000 hospitalizations and 50,000 fatalities annually. Traumatic axonal injury (TAI) is a serious outcome of TBI that accounts for 40-50% of hospitalizations due to head injury and one third of the mortality …
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Diffuse Brain Injury Triggers Ultra-Rapid Perisomatic Traumatic Axonal Injury, Wallerian Change, and Non-Specific Inflammatory Responses
A significant component of diffuse brain injury (DBI) is diffuse axonal injury (DAI) which is responsible for the morbidity and mortality associated with this condition. DAI and its experimental counterpart traumatic axonal injury (TAI) result in scattered microscopic pathology characterized by …
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An Investigation Of The Relationship Between Axonal Injury, Biomarker Expression And Mechanical Response In A Rodent Head Impact Acceleration Model
… 1.4 million people sustain traumatic brain injury (TBI) each year, resulting in 235,000 hospitalizations and 50,000 fatalities annually. Traumatic axonal injury (TAI) is a serious outcome of TBI that accounts for 40-50% of hospitalizations due to head injury and one third of the mortality …
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The characterization of the anterograde and retrograde consequences of traumatic axonal injury in a mouse model of diffuse brain injury
Traumatic axonal injury (TAI) is a consistent feature of (TBI) and is responsible for much of its associated morbidity. TAI is now recognized to result from progressive/secondary axonal injury, though much remains unknown in regards to the pathobiology and the long-term consequences of axonal …
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Axonal Damage in Repetitive Concussive Traumatic Brain Injury: Characterization and Contributing Factors
… model of repetitive concussive traumatic brain injury (rcTBI) was developed. Initial studies sought to characterize the histological and functional changes that occur after two closed-skull impacts in mouse. Similar to human traumatic brain injury, rcTBI produced axonal injury evident by amyloid …
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Discerning the Mechanism of Gamma Delta T Cell-Mediated Damage in Multiple Sclerosis: the Potential Role of Antibodies in Disease Pathogenesis
… adaptive immune systems contribute to autoimmune injury in multiple sclerosis (MS). We have been particularly interested in elucidating the role of the innate γδ T-cell population in MS pathogenesis. In particular, some γδ T-cells that express Fc receptors (FcR), such as CD16, that bind antibody …
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Regulation of peripheral nerve regeneration by the mTOR pathway
… ability to regenerate their axons following injury. Successful regeneration depends upon both extrinsic cues in the environment and the activation of intrinsic mechanisms to promote regrowth. A number of inhibitory molecules in the CNS environment that prevent axonal regrowth have been …
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Cellular pathology and apoptosis in experimental and human acute and chronic compressive myelopathy.
… the 9 week compression group (mean 0.19). APP axonal immunopositivity was frequently seen after decompression. Following experimental acute compression, central necrosis was seen, surrounded by axonal swellings and inflammatory infiltrate. Glial positivity using TUNEL occurred at 24 hours and 1 …
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Automated multi-well neural injury device
Traumatic Brain Injury (TBI) is a wide spread pathological problem occurring in 1.4 million individuals every year according to the National Institute of Neurological Disorders and Stroke. There are several types of TBI and the most prominent ones are concussion, contusion, hematoma, …
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Multi well uni-axial stretch injury device
Most diffuse brain injury is the result of uni-axial stretch of brain axons in traumatic brain injury. Traumatic injury to axons throughout the brain and is believed to be a major cause for coma, and other complications. Diffuse axonal injury is mostly multi-focal and appears throughout the deep …
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Molecular Expression of Neuroprotective and Neurodestructive Signaling Systems Following Axotomy-Induced Target Disconnection: Relevance to ALS
… Our lab utilizes a peripheral nerve injury model to investigate the mechanisms of MN survival in the pre-symptomatic SOD1 mouse. We have shown SOD1 mice display enhanced facial MN (FMN) cell loss following a facial nerve axotomy, compared to wild-type (WT) mice. Analysis of gene …
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Mitochondria, Inflammation, and T-Cell Metabolism in a Rat Model of Pediatric Mild Traumatic Brain Injury
… in Canada every year, pediatric traumatic brain injury (TBI) can be an intractable medical problem with limited treatment options. While most research has been directed towards the devastating, moderate-severe end of the TBI spectrum, most clinical injuries present as mild with minimal duration …
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Computational Investigation On The Structural Properties Of Neurofilaments And Their Sidearms
… axons. They are the key determinants of axonal diameter and consequently the nerve conduction properties. On the other hand, abnormal NF accumulation has been the hallmark of debilitating neurodegenerative disorders. NF compaction is also one of the pathological manifestations of …
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Neurite inhibiting factors from the developing and mature spinal cord
… 1985). During this early embryonic period axonal injury is readily repaired, in part due to the similar environments required by developing and regenerating axons (Shimizu et al., 1990). Soon after completing the development of long ascending and descending tracts the environment of the …
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Continuous Multi-Modal Monitoring of Cerebrovascular Reactivity in Adult Traumatic Brain Injury
… autoregulation following traumatic brain injury (TBI) in adults has been linked to worse global outcome. Continuously updating indices of cerebrovascular reactivity provide a convenient and continuous metric regarding an individual patients’ autoregulatory status. To date, the vast …
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