Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 378 for “"Axonal"”.
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Mitochondrial response to axonal injury
The failure of axonal regeneration is due to myriad reasons both cell intrinsic and extrinsic. In this thesis, I sought to investigate an intrinsic reason for regeneration failure in the CNS. Specifically, I investigated the role of axonal mitochondria in the axonal response to injury. A viral …
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ROS regulation of axonal mitochondrial transport
… Oxidative stress and abnormal mitochondrial axonal transport are associated with neurodegenerative disorders. However, we know little about the connection between these two. Using primary<em>Drosophila</em> neuronal cell culture and the third instar larval nervous system as in vitro and in …
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Axonal Translation and Links to Neuropathies
… of an organism. Spatiotemporal regulation of the axonal proteome by local protein synthesis (LPS) plays a critical role in neuronal wiring and axon survival, raising the intriguing possibility that some neurological disorders involve LPS dysfunction. To visualise LPS in situ, I optimised multiple …
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Axonal growth : modes, molecules and mechanisms
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 1989.
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Modulation of Axonal Transmission by Metabolic Stress
Electrical signaling by neural tissue is responsible for ~20% of the basal metabolic rate. This high-energy consumption predisposes neural tissue to metabolic stress that can compromise signaling and cause irreversible damage. The locust central nervous system (CNS), however, has adaptive …
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Promoting bridging axonal regeneration after spinal cord injury
… the extent to which OECs promote long distance axonal regeneration when transplanted into spinal cord lesions. In the first chapter of Results (chapter 3) we aimed to determine the potential of OEC transplantation in promoting axonal regeneration beyond the injury. This was investigated by …
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The role of Huntingtin in fast axonal transport
… To evaluate the putative function of Htt in fast axonal transport, we characterized the co-localization of the Drosophila Htt homolog tagged with mRFP (dHtt-RFP), and the alterations in axonal transport kinetics associated with a dhtt null. We find that dHtt co-localizes with a subset of cargos …
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Diffuse axonal injury effect on myelinating cells and axons
… evidence whether myelin degeneration in diffuse axonal injury (DAI) of the white matter is due to death of myelinating oligodendrocytes or secondary axotomy. Cortical neurons are not able to remain healthy in culture to have their axons myelinated. Dorsal root ganglion (DRG) neurons have been …
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Investigating the assembly of axonal domains for saltatory conduction
The assembly of functional axonal domains including the axon initial segment (AIS) and nodes of Ranvier in myelinated fibres are essential in promoting nerve impulse conduction in the vertebrate central and peripheral nervous system (CNS and PNS). We still do not fully understand what determines …
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Neuronal Polarization and Axonal mRNA Localization on Microfabricated Substrates
… to determine their effects on the direction of axonal extension. Next, to look at subcellular events during axon outgrowth, the second half of the dissertation utilized a PDMS microdevice to isolate purified axonal mRNA transcripts for microarray analysis. The list of axonal mRNAs generated will …
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Longitudinal Changes in Resting-State Connectivity after Traumatic Axonal Injury
… connectivity immediately after a traumatic axonal injury (TAI). This is the first longitudinal study in TAI to examine functional connectivity in the Default Mode Network (DMN) and Central Executive Network (CEN) within 48 hours after traumatic brain injury with repeat imaging 7 months …
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Non-Canonical Axonal Insulin Receptor Signaling Drives Aversive Olfactory Learning
… I describe the cell-specific activity of an axonally-localized isoform of the insulin receptor DAF-2 in aversive learning. I perform epistasis studies of ist-1 with other members of the insulin signaling pathway to ask how they regulate aversive learning together. In Chapter 4, I characterize …
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Effect of nitric oxide and inflammatory mediators on axonal transport
… Mediatoren über die c-Jun-Kinase den axonalen Transport von synaptischen Proteinen und Mitochondrien inhibieren.
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Investigating the Role of MicroRNAs in Regeneration and Axonal Pathfinding
… environment to change the direction of axonal outgrowth. MicroRNAs, which regulate mRNA translation, have recently been shown to regulate both neurite outgrowth and growth cone guidance in response to classical guidance cues during vertebrate development. However, little is known of …
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The Heparan Sulfate Proteoglycan Perlecan Regulates Axonal and Synaptic Stability
… Perlecan in the maintenance of larval motoneuron axonal and synaptic stability. In Chapter 1, I discuss known roles for Perlecan and other HSPGs in animal development, with a focus on their functions within the nervous system. In Chapter 2, I describe how loss of Drosophila Perlecan causes …
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Mitofusin 2 Regulated Transport of Mitochondria is Necessary for Axonal Integrity
The ubiquitous finding of axonal degeneration in a number of the most prevalent neuropathologies marks the importance of understanding axonal biology and the axonal self-destruct mechanism. Though our understanding of axonal degeneration remains largely incomplete, several down-steam steps of the …
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Analysis of axonal transport and molecular chaperones during neurodegeneration in drosophila
… systems in early neurodegenerative changes. Axonal transport (AT) is perturbed in several prevalent neurodegenerative diseases. The development of a Huntington’s Disease (HD) model in Drosophila melanogaster larvae is described, in which disease gene expression is directed to motor neurons …
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Axonal Transport of Glycoproteins and Glycolipids in the Goldfish Optic System
… is a convenient experimental system for studying axonal transport. Radioactive precursors are injected into the eye, and radioactivity which is transported in the axons of the retinal ganglion cells can be studied as it moves in the optic nerve and optic tract to the optic tectum, where the optic …
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Axonal transport and life cycle of mitochondria in Parkinson's disease model
… deficient animals displayed less number of axonal mitochondria without disturbing organelle motility behaviors, morphology and metabolic state. Instead, loss of Parkin produced tubular and reticular mitochondria specifically in motor neuronal cell body. In addition, unlike in immortalized …
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