Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Axon regeneration"”.
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Gene therapy for axon regeneration
… many factors that contribute to the failure of axon regeneration in the CNS. Generally speaking, the problem of axon regeneration can be subdivided in at least two aspects: 1) the growth-repulsive environment surrounding the injured axon and 2) the low intrinsic regeneration potential of adult …
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MODIFYING CHONDROITIN SULFATION ENHANCES RETINAL GANGLION CELL AXON REGENERATION
… of mammalian CNS neurons to regenerate their axons derives from a combination of intrinsic deficits and extrinsic obstacles. Following injury, chondroitin sulfate proteoglycans (CSPGs) accumulate within the glial scar that forms at the lesion site in response to the insult. CSPGs inhibit …
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Olfactory ensheathing cell mediated mechanisms of neurite outgrowth and axon regeneration
… neuraxis to undergo neuronal replacement and axon targeting following injury, has led to scrutiny concerning the molecular and physical determinants of this growth capacity. This is because injury to the central nervous system, in contrast, leads to permanent disconnection of neurons with …
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Macrophage recruitment in DRG contributes to sensory axon regeneration after conditioning injury
… and accompanying inflammatory reactions in axonal regeneration. However, it has not been addressed whether macrophages in DRG play role in CI-induced axon regeneration. In this thesis research, I examined whether the macrophages in DRGs contribute to the CI-induced sensory axon regeneration. …
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Development of a novel screening platform for identifying genetic pathways regulating axon regeneration
… and pathways that have never been implicated in axon regeneration. However, we still lack a complete understanding of the repertoire of genetic factors that can promote or inhibit axonal regrowth after neural damage. Given that neurons have polarized morphology with distinct cellular …
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Investigating protrudin’s role in neuroprotection and axon regeneration in the central nervous system
… shown to strongly promote neuronal survival and axon regeneration after central nervous system (CNS) injury. This is in part due to increased levels of integrins in the distal axon, but this mechanism does not fully account for its beneficial effects. We have investigated protrudin's effects on …
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The Effect of Manipulation of the Phosphoinositide 3-kinase Pathway on Axon Regeneration in vivo
… is comprised of retinal ganglion cell (RGC) axons, and like all mammalian central nervous system axons, they fail to regenerate due to a combination of extrinsic and intrinsic factors. Current treatments have limited success preventing disease progression, and this failed regeneration …
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The expression and functional role of Tenascin-R during axon regeneration in the adult goldfish, Carassius auratus
Includes bibliographical references (leaves 126-144).
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Promoting Central Nervous System Regeneration by Targeting Intracellular Pathways
… essential growth-molecules become excluded from axons with maturation. In this thesis, two strategies were employed in order to improve axon regeneration: 1) restoring the axonal transport of growth-molecules in mature axons via manipulation of transport machinery; 2) reverting mature neurons to …
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Enhancing spinal cord repair with connexin43 antisense oligodeoxynucleotides
… have been used successfully to promote axon outgrowth from damaged spinal cord but such regeneration is limited by new scarring resulting from the intervention itself. We have investigated the effect of Cx43 downregulation in preventing the onset of secondary injury spread and enhancing …
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Nano-based drug delivery systems: Targeting to corticospinal tract neurons for controlled release of therapeutics
… could be improved by therapies encouraging axon regeneration. However, therapeutic effectiveness is challenged by limited CNS axon regeneration, limited CNS accessibility due to the blood-brain barrier (BBB), and inefficient targeting to specific neurons due to CNS cellular diversity. We …
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Expression and regulation of genes associated with CNS regeneration and plasticity
… 1 B. Factors for the failure of CNS axon regeneration 2 C. Conditioning injury (CI)-induced axon regeneration 3 D. Regeneration associated genes (RAGs) 4 E. Epigenetics 5 F. Neuroepigenetics in CNS injury 8 G. Next generation sequencing (NGS) in epigenomic studies 10 H. Aims of this …
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The expression and functional analysis of neurite outgrowth inhibitors in the nervous system of Xenopus laevis
… factors contributing to success or failure of axon regeneration lie in the intrinsic properties of the injured neurons, as well as the surrounding microenvironment of the transected axon. Mammalian neurons may lack the intrinsic ability to survive after trauma, or to re-express genes required …
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Design of three-dimensional axon stretch growth device
… (SCI) causes destruction and degeneration of axons in the white matter of the spinal cord, resulting in functional loss and paralysis. A successful treatment of SCI requires axons to regenerate across damaged regions. Current studies focus on identifying mechanisms to promote axon regeneration …
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The characterization of the anterograde and retrograde consequences of traumatic axonal injury in a mouse model of diffuse brain injury
Traumatic axonal injury (TAI) is a consistent feature of (TBI) and is responsible for much of its associated morbidity. TAI is now recognized to result from progressive/secondary axonal injury, though much remains unknown in regards to the pathobiology and the long-term consequences of axonal …
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Collagen scaffolds in full- and hemi- resection spinal cord injury models
… important factors that contribute to the lack of regeneration following the initial traumatic injury and secondary injury response in the adult spinal cord. These factors include both intrinsic limitations in the regeneration capacity of mature neurons, but also a host of environmental factors …
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The interconnected roles of spastin and protrudin in endosomal sorting
… Considering protrudin is a potent enhancer of axon regeneration in the central nervous system, this might also help to elucidate the mechanisms underlying axonal health.
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The Role of Nogo-A During Development of the Chick Central Nervous System
<p>Nogo-A is a potent inhibitor of axon regeneration that is expressed by myelin forming oligodendrocytes of the adult central nervous system (CNS). However, neuronal expression of Nogo-A during development suggests an additional role. Little is known about the putative functions of Nogo-A during …
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Pilot Study Exploring the Effect of Targeted COX-2 Inhibition in Macrophages Responding to Neuronal Injury; Promoting Enhanced Axonal Regeneration
… evaluated the potential impact of CXB-NE on neuroregeneration. In CCI, the injury and inflammation damages nerves, leading to axon degeneration distal from the site of injury. While peripheral nerves can regenerate axons, if axonal degeneration continues to occur due to inflammation, then axonal …
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