Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 78 for “"Axon guidance"”.
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Axon Guidance In The Mouse Olfactory System
… drive microarray based method to identify novel axon guidance molecules expressed by the target of this process, the olfactory bulb. This method is designed to identify genes that are differentially expressed within the developing olfactory bulb during the developmental stages when olfactory …
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Compartmentalization and axon guidance in the Drosophila brain
… cell mispositioning and aberrant photoreceptor axon targeting. Thus, Slit and Robo proteins are required to restrict movement of cells across the lamina/lobula boundary. Additionally, I have characterized Ptpmeg, a highly conserved protein tyrosine phosphatase (PTP). In addition to the …
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Axon guidance in the zebrafish visual system: Analysis of Esrom Mutant
… mutant esrom shows that it is required for axon fasciculation, targeting, branching and skin pigmentation. In the visual system esrom is necessary for the formation of topographic map along the A-P and D-V axis, correct innervation of the pretectal targets and axon bundling in the optic …
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Balancing growth and repulsion: Slit proteolysis generates diverse signals in axon guidance
… movement. Neurons extend long projections called axons to connect with distant targets, a process controlled by axon guidance. Axons are guided to the correct location by extracellular axon guidance cues. Key regulators of axon guidance are large secreted proteins called Slits. Slits were first …
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The role of tissue viscoelasticity in axon guidance during Xenopus brain development
During nervous system development, axon bundles grow over large distances along well-defined pathways, guided by gradients of chemical cues in their environment. In addition, axons mechanically interact with their environment and respond to stiffness gradients they may encounter in the developing …
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TOWARDS RETINA REGENERATION: THE EPIGENETIC BASIS OF NEURONAL AND AXON GUIDANCE GENE REGULATION
… regulating expression of RGC specific and axon-guidance genes during development and in retinal stem cells is key for successful optic nerve regeneration. I proposed that dedifferentation of Müller glia to RGCs is restricted by silencing of RGC specific and axon guidance genes by chromatin …
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Development and application of optical microscopy tools for the study of axon guidance
During their development, neurons extend axons towards their target cells, where they branch to establish connections. The navigation of axons relies on the presence of chemical cues sensed through guidance cue receptors. Upon receptor activation, intracellular signalling pathways are initiated, …
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Mummy regulates slit-robo signaling to mediate axon guidance in drosophila embryonic nerve cord
… integrity of the nervous system. Mutations in axon guidance molecules have been reported to cause various human nervous system disorders. The Slit-Robo signaling pathway is a well-studied evolutionarily conserved axon guidance mechanism. Slit is a chemo-repellant secreted by midline glial cells …
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Large-Scale RNAi Screen to Identify Genes Involved in Axon Guidance in Caenorhabditis elegans
Diese Arbeit wurde durchgeführt, um Gene, die axonale Wegfindung im Nervensystem von Caenorhabditis elegans steuern, zu identifizieren. C. elegans stellt aufgrund seiner einzigartigen physiologischen Eigenschaften ein gutes Modellsystem für das Studium einer Vielzahl biologischer Prozesse dar. Das …
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Establishing Neuronal Diversity: Regulation of olfactory receptor neuron specification and axon guidance in Drosophila
… and heterophilically interact, is required for axon sorting among classes of ORNs to create 50 class specific glomeruli. The members of this family are expressed in a combinatorial code in ORNs at times that correlate to glomerular formation. Computational analysis of DIP/Dpr expression patterns …
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Axon Guidance Autonomy and Tensional Requirement for Synaptic Function: Is Learning a Forced Response
… In culture, detached growth cones display guidance autonomy, contain mRNA for cytoskeletal and other axonal components, and are capable of synthesizing protein locally. However, the extent to which growth cone's autonomy contributes to its pathfinding function within the complex in vivo …
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Elucidation of the Retinoid Signalling Pathway Involved in Axon Guidance in Lymnaea stagnalis and Xenopus laevis
… Moreover, RA has been shown to act as a guidance molecule for growth cones of regenerating motorneurons of the pond snail, Lymnaea stagnalis. Our lab has recently shown that RA can induce this morphological response independent of nuclear transcription, however, the role of the retinoid …
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The Intracellular Domain of the Frazzled/Dcc Receptor is a Transcription Factor Required for Commissural Axon Guidance
… families of attractive and repulsive cues steer axons by signaling through receptors that are expressed on axonal growth cones. In the canonical model of axon guidance receptor signaling, ligand binding induces the formation of protein complexes on receptor cytoplasmic domains, which locally …
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Signal Transduction Mechanisms in Commissural Axon Guidance: The Role of Intracellular Tyrosine Kinases in Netrin-Dcc/Frazzled Axon Attraction
… the stepwise process of neural specification, axon guidance and synaptogenesis. Axon guidance, the process by which neurons extend axons to their final targets, relies on the presence of extracellular cues, and their respective guidance receptors. Intracellular molecules that transduce these …
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Novel EphB Receptor Forward Signaling Pathways in the Development of Major White Matter Tracts of the Mammalian Brain
… and subsequent developmental steps, including axon guidance, establish the functional circuitry between young neurons. Axon guidance is characterized by the growth of axonal processes that sprout from neuronal cell bodies and navigate within the developing brain to reach target synaptic zones. …
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An investigation into novel molecules involved in the development of the nervous system of Drosophila melanogaster
… system development entails the projection of axons from neuronal cell bodies towards synaptic partners, such as other neurons or muscles. This process, referred to as “axon guidance,” relies upon receptors on axons detecting secreted or membrane-associated guidance cues within the developing …
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The receptor tyrosine phosphatase Ptp69D and the receptor tyrosine kinase Pvr in Drosophila nervous system development
Cell migration and axon guidance are highly similar processes important for the development of the nervous system. Both processes involve the transduction of signals across the membrane, resulting in changes in the cytoskeleton. I have examined the roles of two receptors that are involved in axon …
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A lentiviral system for RNAi transgenesis and the Ena/VASP triple-knockout defines neuronal and non-neuronal functions in mouse development
… signaling pathways that function exclusively in axon guidance in lower organisms. This emerging paradigm employs complex expression patterns of expanded protein families to achieve the complexity and specificity required in mammalian development. For example, the Drosophila axon guidance ligands, …
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Dissecting the Physiological Roles of ULK1/2 in the Mouse Brain
… UNC-51 and D. melanogaster Atg1 also promote axonal growth and defasciculation, and disruption of these genes results in defects in axon guidance in invertebrates. Germline Ulk1/2-deficient mice die perinatally. Therefore, we used a conditional-knockout approach to investigate the roles of …
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