Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Axin2"”.
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Wnt/beta-Catenin-Zielgene in der Mausentwicklung
… Wnt1-stimulierten ES-Zellen erhöht war, darunter Axin2 und Follistatin. <br>Im weiteren Verlauf der Arbeit konnte gezeigt werden, dass Axin2 und Follistatin direkte Zielgene des Wnt/beta-Catenin-Signalwegs sind. Durch die in vitro Charakterisierung von 5’-regulatorischen Sequenzen in …
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Recapitulating mammary gland development and breast cancer cell migration in vitro using 3D engineered scaffolds
… in vitro 3D model. Fluorescently tagged murine Axin2-expressing cells were obtained from transgenic mice and seeded into these scaffolds and cultured, mimicking the process of fat pad repopulation. Immunohistochemical analysis demonstrated that Axin2+ myoepithelial cells were rarely capable of …
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Epigenetic Modulation In Braf Mutated Metastatic Colorectal Cancer
… of Wnt/β-catenin signaling like RNF43 and Axin2 were significantly underexpressed in BRAF V600E mutant tumors when compared to their wild-type counterparts. These genes were hypermethylated in the xenograft models, which could be reversed with a demethylating agent.</p> …
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Trim28 Interacts With Ezh2 to Regulate Its Activity
… at TRIM28 binding sites. The promoter of <em>AXIN2</em>, which encompasses a TCF4 binding motif, is a direct transcriptional activation target of TRIM28. Collectively, we demonstrated a mechanism of regulation of breast cancer cell proliferation by TRIM28 in a phosphorylation dependent manner …
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Regulation of Lung Mesenchymal Cells By Epithelial Wnt Ligands
… which additionally showed reduction in <em>Axin2</em>, a canonical Wnt target gene, specifically in the neonatal alveolar myofibroblasts and adult pericytes. Indeed, separate and independent conditional deletion of <em>Ctnnb1</em> in alveolar myofibroblasts and pericytes recapitulated the …
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Identifying Novel Molecular Mechanisms Underlying Lateral Line Organ Development in Sterlet
… neuromasts but not AOs, and four (Dll4, Axin2, Omg and Gpr52) within developing AOs but not neuromasts. (Other genes with specific expression patterns were expressed in non-lateral line structures such as gill filaments and taste buds.) I explored the Bmp signalling pathway in the most …
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New insights into cornea-lens regeneration in Xenopus laevis: the role of Wnt/beta-catenin signaling and the regenerative capacity of the limbal region
… occurring within the cornea epithelium, axin2 expression was measured over the course of regeneration. axin2 is a well-established reporter of active Wnt/β-catenin signaling, and its expression shows a significant decrease at 24 hours post-lentectomy. This decrease recovers to normal …
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NEU4L INDUCES ALTERATIONS ON CELL PROLIFERATION AND DIFFERENTIATION IN NEUROBLASTOMA CELL LINE, SK-N-BE
… as mRNA (-30%), while c-myc, cyclin D2 and axin2, which have been identified as target genes of -Catenin (3), underwent a significant increase, as mRNA content, in Neu4L over-expressing SK-N-BE cells. In order to further confirm the activation of the Wnt canonical pathway, we transiently …
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Exploring Molecular Mechanisms Controlling Skin Homeostasis and Hair Growth. MicroRNAs in Hair-cycle-Dependent Gene Regulation, Hair Growth and Associated Tissue Remodelling.
… of the expression of the Wnt target gene VI Axin2. This suggests that miR-214 may indeed be involved in regulation of skin development and regeneration at least in part, by controlling the expression of ¿-catenin and the activity of the Wnt signalling pathway. To address Aim 3, the role of …