Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Axin"”.
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Mechanisms Regulating The P120-Catenin/Kaiso Pathway
… destruction-complex components such as GSK3b or Axin promotes p120-catenin degradation, and consequently, is able to rescue developmental phenotypes resulting from p120 over-expression during early <em>Xenopus</em> embryonic development. Conversely, as predicted, the in vivo depletion of either …
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Large-Scale RNAi Screen to Identify Genes Involved in Axon Guidance in Caenorhabditis elegans
… Beispielsweise führt Verlust von pry-1, einem Axin Homolog in C. elegans, zu axonalen Defekten. Axin ist ein assoziierter Faktor des ß-Catenin Komplexes und damit ein negativer Regulator in Wnt vermittelter Signaltransduktion. Weitere Studien an anderen, in diesem Screen identifizierten …
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COMPARATIVE CELL BASED FUNCTIONAL ANALYSIS OF KEY WNT/BETA-CATENIN PATHWAY GENES AND GENE MUTATIONS
… by GSK3 Beta; in a complex with APC, AXIN, and CK1. Phosphorylation promotes ubiquitination of Beta-catenin and subsequent proteasomal degradation. When a Wnt-ligand binds to a Frizzled receptor, a signaling cascade displaces GSK3 Beta from its complex with Beta-catenin allowing …
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Regulation of Protein Degradation by ADP-Ribosylation
… Iduna E3 ubiquitin ligase in the regulation of Axin and Tankyrase proteolysis. I found that Iduna controls the proliferation of stem cells in the Drosophila midgut. Using a MS-based approach, I identified lysine 598 as an ADP-ribose acceptor site in Drosophila Tankyrase and showed that TnksK598A …
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Effects of Binge Alcohol Exposure on Canonical Wnt Signaling During Fracture Repair
… Sox9, Runx2, beta-catenin, GSK-3beta, and Axin. Lastly, alcohol-treated mice that received LiCl showed improved callus strength, restoration of normal cartilage formation and endochondral ossification in the callus tissue, and enhanced total and activated beta-catenin protein levels to …
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Funktion und Evolution von hochkonservierten Kopfgenen im Reismehlkäfer Tribolium castaneum
… weiter zu bestätigen, habe ich mit Hilfe von Tc-axin RNAi ektopische Wnt Signale in der anterioren Region aktiviert. Die Resultate zeigen, dass ektopische Wnt Signale zur Posteriorisierung des frühen Embryos führen, was für eine essentielle Funktion des Wnt-Signalweges in der anterior-posterior …
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RacGap50C Is a Novel Negative Regulator of Wnt Signaling
… also interact genetically with naked cuticle and Axin, known negative regulators of the Wg pathway. These phenotypes suggest that the RacGap50C gene product participates in the negative regulation of Wg pathway activity. </p><p>In addition to the role of RacGap50C in regulating Wg signaling, …