Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Avy"”.
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Epigenetic Response to Low-Dose Ionizing Radiation
… the epigenome. </p><p>The viable yellow agouti (Avy) mouse was used here to characterize the dose-dependent epigenetic response to LDIR. The Avy mouse is a unique biological model that functions as a biosensor for environmentally induced epigenetic changes and disease susceptibility due to the …
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Variable DNA methylation in the mouse genome: repetitive elements, unique regions and functional implications
… histone modifications and DNA methylation. The Avy allele results from an IAP insertion into the endogenous Agouti gene locus which is variably silenced between isogenic individuals. Variable DNA methylation at the IAP inversely correlates with ectopic expression of Agouti, resulting in a …
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Identification and characterisation of murine metastable epialleles conferred by endogenous retroviruses
… epialleles’. The best known example is the Avy locus where an endogenous retrovirus (ERV) of the intracisternal A-particle (IAP) class was spontaneously inserted upstream of the agouti coat colour gene, resulting in variable IAP promoter DNA methylation, variable expressivity of coat …
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Variable methylation of endogenous retroviruses: epigenetic inheritance, environmental modulation, and genetic modifiers
… has shown that, at the Agouti Viable Yellow (Avy) locus, an IAP insertion provides an alternative promoter for the Agouti coat colour gene. Variable methylation of this IAP is correlated with coat colour expressivity. In addition, the Avy allele exhibits transgenerational epigenetic …