Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Auts2"”.
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Dissecting the role of AUTS2 and GALNT17 in neurodevelopment using a mouse model for human AUTS2 syndrome
… gene, Autism Susceptibility Candidate 2 (AUTS2), and it was first discovered as the gene disrupted by reciprocal translocation in human twins with ASD and ID. Most reported patients have been shown to carry genomic rearrangements within or containing AUTS2. All patients described so far …
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The role of AUTS2 in neurodevelopment and neurological disease
The Autism Susceptibility Candidate 2 (AUTS2) gene is a critical neuronal gene that is involved in several related developmental pathways, including regulation of neurite outgrowth and neuronal migration, and transcriptional activation of neuronally active genes. Disruption of AUTS2 has been …
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Unique and intertwined functions of AUTS2 isoforms in brain development and behavior
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01
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Lentiviral-mediated gene delivery to investigate the functional role of neuropsychiatric genes
… On the other hand, a gene of unknown function, AUTS2 (Autism susceptibility candidate 2), has recently been associated with alcohol consumption in a GWAS meta-analysis performed by our group. Interestingly, it has been associated with a broad range of neuropsychiatric disorders including autism, …
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Characterising molecular and cellular mechanisms of human brain evolution using brain organoids
… We find that the transcriptional regulator, AUTS2, has a dramatic effect on cell fate and tissue architecture. By generating organoids with loss-of-function of C-terminal-containing AUTS2 isoforms, we find neurogenesis is premature, which may reflect the microcephaly observed in humans with …