Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Autoreactivity"”.
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Autoreaktyvumo rodiklių diagnostinė reikšmė sergant lėtine dilgėline /
… was to evaluate the diagnostic significance of autoreactivity markers and their correlation in chronic urticaria patients. Sera from patients with chronic urticaria significantly upregulate both CD63 and CD203c molekules on donor blood basophils. Estimated cut-off value of the tests was 10%. The …
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Autoreaktyvumo rodiklių diagnostinė reikšmė sergant lėtine dilgėline /
… was to evaluate the diagnostic significance of autoreactivity markers and their correlation in chronic urticaria patients. Sera from patients with chronic urticaria significantly upregulate both CD63 and CD203c molekules on donor blood basophils. Estimated cut-off value of the tests was 10%. The …
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Modulation of Ly49A+ Natural Killer Cell Licensing by Major Histocompatibility Complex Class I Alleles
… termed NK cell licensing, to protect against autoreactivity. To become licensed, i.e. functionally competent to be triggered through its activation receptors, an NK cell must engage host MHC class I via at least one of its MHC class I-specific inhibitory receptors, which in mice belong to the …
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Innate and humoral immune responses to HIV-1
… responses was blocked by inherent autoreactivity and exceptional polyreactivity. We generated 4E10 heavy-chain knock-in mice, which displayed significant B cell dysregulation, consistent with recognition of autoantigen/s by 4E10 and the presumption that tolerance mechanisms may …
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The evolution of the autoantibody response in Graves’ disease
… expansion of B cell populations that acquire autoreactivity in the periphery may be associated with the porin proteins of Y. enterocolitica.
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Role of Bruton’s Tyrosine Kinase and Interleukin-6 in Plasma Cell Accumulation and Autoantibody Production in Lyn-Deficient Mice, A Model of Lupus
… plasma cells co-incident with polyclonal IgM autoreactivity. This is due in part to impaired migration of lyn-/- plasma cells towards SDF-1 and involves a B cell intrinsic effect of Lyn-deficiency. The second checkpoint regulates the class-switching of B cells with lupus-associated autoantigen …
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Enhancement of the An1 Population by BAFF: Potential Role in Autoimmune Disease
… poses a risk of activation and reversion to autoreactivity thus leading to automimmune disease.
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The identification of prostate cancer associated tumour antigens and biomarkers
… PAGE, 2-DE and OFFGEL respectively, exclusive autoreactivity was identified in PCa sera to serum albumin and existing PCa biomarkers - human prostatic acid phosphatase & zinc-alpha-2 glycoprotein. Differential autoantibody responses were also identified to various TAAs in the PC-3 and DU-145 …
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Inhibition of adenosinergic signaling in the tumor immune environment: the effect of combination CD73 blockade and oHSV therapy on solid tumors
… unchecked immune activation can escalate to autoreactivity or toxicity, so this inflammation is frequently accompanied by anti-inflammatory responses to maintain tissue homeostasis. Tumor cells can exploit anti-inflammatory pathways to escape anti-tumor immune responses. Here we identify that …
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Tumor-induced macrophage and T cell dysfunction
… and qualitatively suppressed T-cell autoreactivity partly by dysregulation of interferon-gamma (IFN-y), interleukin-4 (IL-4), and prostaglandin E₂ (PGE₂) production. TBH MΦ had aberrant regulation of granulocyte-macrophage colony-stimulating factor (GM-CSF). TBH MΦ produced less …
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Immune Recognition of Self Nucleic Acids Driven By Endogenous Antimicrobial Peptides: Role In Autoimmunity
… sensing of host cell death. This pathway of autoreactivity was found to be pathologically relevant in human autoimmune diseases psoriasis and SLE, and thus this study provides new insights into the mechanisms autoimmune diseases.
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Autoregulatory CD8 T-Cells Modulate CNS Autoimmune Disease by Targeting Encephalitogenic CD4 T-Cells
… in CD8-/- mice correlated with an increase in autoreactivity and inflammatory cytokine production by myelin-specific CD4 T-cells. This is reversible upon adoptive transfer of MOG₃₅₋₅₅-specific CD8 T-cells. Targeting of encephalitogenic CD4 T-cells by myelin-specific CD8 T-cells is sufficient, …
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STUDIES OF B CELL DEVELOPMENT AND V(D)J RECOMBINATION
… selection stages remove non‑functional and autoreactivity receptors from the final pool of antigen responding B cells that ultimately give rise to antibody secreting plasma cells. Understanding the complexity of the recombination processes and the diversity of the resulting antibody …
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DISSECTING IMMUNE DYSREGULATION IN PATIENTS WITHTHYMIC EPITHELIAL TUMORS BY AUTOANTIBODY ANDSINGLE-CELL PROFILING
… strong internal correlations. In contrast, IgM autoreactivity was reduced in AB and B thymomas yet increased in TH, consistent with sustained unswitched memory B cells and long-term IgM secretion. Together these findings support a model in which aberrant intratumoral thymopoiesis fails to …
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Role of envelope compactness and glycosylation in HIV-1 resistance to neutralising antibody responses
… V3/glycans, the V2/apex and the MPER epitopes. Autoreactivity and polyreactivity of anti-V3/glycan and anti-MPER antibodies are thought to pose both direct and indirect barriers to achieving neutralisation breadth. Chapter 4 of this thesis explored which of these bnAb epitopes were associated …
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Effector Cells and Mechanisms in Chronic Spontaneous Urticaria
… and UV (n=43) patients for the presence of skin autoreactivity or serum HRA and eosinophils/neutrophil numbers per high power field (HPF). There were higher numbers of neutrophils/HPF in UV than CSU patients by haematoxylin and eosin (H&E) staining (p=0.0002) and immunohistochemical detection of …
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Studying the B and plasma cell responses to the immune checkpoint blockade treatment of cancer
… Further work is required to validate fully the autoreactivity of the TdLN response, but the findings from this thesis suggest the response is directed against self-antigens. This could have important implications for how ICB therapy leads to the activation of autoreactive B and plasma cells that …
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Golgi Specificity and Development of Autoreactive B Cells
<p>B cell receptors with certain heavy/light chain pairs predominate in the periphery of anti-DNA heavy chain transgenic mice while certain other B cell receptors are absent. We wanted to know why. To answer this, we re-constructed B cell receptors represented in the anti-DNA transgenic mice by …