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Showing 1 to 16 of 16 for “"Autophagic Cell Death"”.
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Radiation Sensitization of Breast Cancer Cells by Vitamin D Through the Promotion of Autophagic Cell Death
… is often initially effective in killing tumor cells or suppressing their growth, there are factors that confer tumor cell resistance to irradiation. Development of resistance may lead to disease recurrence despite the use of surgery, chemotherapy and radiation therapy. A primary goal of the …
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The Substituted Pyrrole JB-03-14 Induces Autophagic Cell Death and Growth Arrest in Breast Tumor Cells
… agents that are more potent at destroying tumor cell populations and more selective for the specific tumor versus normal host tissues. This project is directed at discovering new anti-tumor agents that are effective against breast cancer based on structures derived from marine organisms, …
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Synergic Effect on Cell Death by Co-treatment with TRAIL and Human Anti-DR5 Antibody
DR5 and DR4, death receptors of TNF-related apoptosis-inducing ligand (TRAIL), are interesting targets of antibody-based cancer therapy since TRAIL itself selectively induces apoptotic cell death in cancer cells but not in normal cells. In previous study we isolated a human single-chain variable …
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Influence of the Vitamin D3 Analog EB 1089 on Senescence and Cell Death Pathways in the Response of Breast Tumor Cells to Ionizing Radiation
… capacity is observed in MCF-7 breast tumor cells exposed to fractionated radiation (5 x 2Gy) alone. Exposure to the vitamin D3 analog EB 1089 (100nM) prior to irradiation converts the initial growth arrest response to cell death in part through the inhibition of radiation-induced senescence …
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Ferroptosis: A Novel Form of Cancer Cell Death Induced by the Small Molecule Erastin
In multicellular organisms, proper control of cell death is important for processes such as embryonic development and turnover of adult tissues. Misregulation of cell death contributes to many diseases, including cancer. Human cancers frequently show defects in their ability to initiate or execute …
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Loperamide enhances bortezomib-mediated cell death in colon cancer cells
… AND METHODS 8 A. Chemicals and antibodies 8 B. Cell culture of various cancer cell lines and normal cells 8 C. Measurement of cell viability 9 D. Western blotting 9 E. Immunocytochemistry 10 F. Establishment of the stable cell lines in the fluorescence specifically endoplasmic reticulum 10 G. …
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Renal Risk Variants of Apolipoprotein L-1 Form Channels at the Plasma Membrane that Lead to a Cytotoxic Influx of Calcium
… risk when present in two copies. In mammalian cells, overexpression of G1 and G2, but not wild-type G0, leads to swelling and eventual lysis. However, the mechanism of cell death remains elusive with multiple pathways being invoked, such as autophagic cell death mediated by a BH3 domain in …
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Induction And Regulation Of Autophagy By Novel Prenylation Inhibitors In Sts-26t Malignant Peripheral Nerve Sheath Tumor (mpnst) Cells
… transferase (GGTase) enzymes in many cellular and animal models of cancer. Some of these have also been evaluated in clinical trials with limited success. Multiple mechanisms of action have been elucidated for such compounds, including cell cycle arrest, proteasome inhibition, …
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Starvation Response in Caenorhabditis elegans
… of environmental nutrients is limited, multicellular animas can make physiological and behavioral changes so as to cope with nutrient starvation. Although starvation response is essential for the survival of animals during nutrient deprivation, uncontrolled or uncoordinated starvation …
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The Effects of a Purified B-Group Soyasaponin Fraction on the Proliferation, Cell Cycle Progression and Induction of Macroautophagy in Hct-15 Human Colon Adenocarcinoma Cells
… in cultures of HCT-15 human colon adenocarcinoma cells. Treatment of cells with the soyasaponins at concentrations of 25-500 ppm significantly reduced viable cell numbers after 24 and 48 hours of exposure, an effect that was specific to cancer cells. Treatment of cells with 25 and 100 ppm of …
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Mechanisms of Adenovirus-Mediated Autophagy
… therapies and apoptosis. Thus other avenues of cell death urgently need to be explored. Autophagy, which is also known as programmed cell death type II, has recently been identified as an alternative mechanism to kill apoptosis- resistant cancer cells. Traditionally, researchers have studied how …
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Mechanisms of Adenovirus-Mediated Autophagy
… therapies and apoptosis. Thus other avenues of cell death urgently need to be explored. Autophagy, which is also known as programmed cell death type II, has recently been identified as an alternative mechanism to kill apoptosis- resistant cancer cells. Traditionally, researchers have studied how …
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The Role of The Diras Family Members In Regulating Ras Function, Cancer Growth and Autophagy
… required for the induction of autophagy in human cells. While <em>DIRAS3</em> is found in the genome of humans, pigs and cows, it maps to an apparent evolutionary breakpoint in the rodent lineage where chromosomes have been rearranged relative to the human genome since the two species shared a …
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Selective Elimination of Malignant Melanoma Using The Novel Anti-Tumor Agents, Osw-1 and Peitc
… in melanoma.</p> <p>OSW-1 inhibited melanoma cell viability at nanomolar concentrations with minimal toxicity to normal melanocytes. Mechanistic studies revealed that OSW-1 suppressed Disialoganglioside 3 Synthase (GD3S) gene expression in melanoma cells, leading to inhibition of gangliosides …
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The Effect of Drugs of Abuse and HIV-1 GP120 on Autophagy in Astrocytes
… The neuropathological manifestation results from cell death in the CNS wherein autophagy is expected to play an important role. Autophagy is generally considered protective during deprivation or stress. However, excessive autophagy can be destructive, leading to autophagic cell death. The present …
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Biomedical applications for bacteriocins in infection and oncology
… examination that nisin Z elicited apoptotic cell death in 4 colorectal cancer cell lines and potentially autophagy mediated cell death in 2 oesophageal cancer cell lines. Confocal microscopy analysis along with flow cytometry profiles further supported autophagic cell death in oesophageal …