Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 137 for “"Autocrine"”.
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Computational Studies of Autocrine Ligand Binding
Autocrine ligand secretion and binding to cell surface receptors regulate cell behavior in a number of important physiological functions. At the same time, some pathological conditions such as the unmitigated growth of tumors can also act through this type of stimulation. Interpretation of …
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Quantitative studies of EGFR autocrine induced cell signaling and migration
Epidermal growth factor (EGF) receptor autocrine and/or paracrine signaling plays an important role in normal epithelial cell proliferation, survival, adhesion and migration. Aberrant expression of the EGF receptor and its cognate ligands have been implicated in various types of cancers, hence EGF …
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Autocrine Effects of Catecholamines on Macrophage Release of Interleukin-6 (IL-6)
… (IL-6). This study was designed to clarify the autocrine role of macrophage-derived NE on IL-6 production in activated peritoneal macrophages. Effects of NE on IL-6 production in the RAW264.7 macrophage cell-line also were investigated. Treatment of activated peritoneal macrophages with …
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Autocrine regulation of gonadotropin-releasing hormone in immortalized hypothalamic GT1-7 neurons
The existence of an ultrashort feedback mechanism regulating GnRH secretion has been supported from in vivo and in vitro studies. However, the complex synaptic connections of GnRH neurons with other neural elements made it difficult to determine whether the regulation was mediated by direct actions …
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Role of autocrine growth factors in the tumorigenic transformation of T cells
… T cells may result from aberrant regulation of autocrine growth factor production. We describe for the first time characterization of several normal T cell lines that underwent spontaneous transformation resulting from constitutive expression of interleukin-2 (IL-2) and interleukin 2 receptor …
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Human trophoblast survival and invasion in the developing placenta: autocrine regulation by hbegf
… against apoptosis, and is involved in an autocrine signaling mechanism that leads to its own protein synthesis. CTBs exist in a low O<sub>2</sub> environment during the first 10 weeks of implantation, during which they invade the decidualized uterine stroma. Inhibitors of intracellular …
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A general method for studying autocrine signaling and its impact on cancer cell growth
Autocrine signaling plays essential roles in providing self-sustaining growth signals to cancer cells. Since the introduction of the autocrine hypothesis in 1980s, the contribution of autocrine signaling in cancer medicine has been limited to cancer tissues with adequately characterized mitogenic …
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Evidence for the autocrine/paracrine regulation of tissue growth by the insulin-like growth factors
… and IGF-II) in regulating this growth in an autocrine/paracrine manner.
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Regulation of Bovine Mammary Epithelial Cell Response by Autocrine IGF-I and by Collagen I
… how binding protein profile were influenced by autocrine IGF-I and by collagen I. The MAC-T cell line was chosen as the cell model utilized in these investigations because it is an immortalized bovine mammary epithelial cell line known to retain hormonal responsiveness to IGF-I. It was …
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Quantification of receptor-ligand interactions on bioengineered autocrine call system : a comparision of theory and experiments
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1997.
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Quantitative analysis and modulation of the spatial operation of the EGF receptor autocrine cell signaling system
The spatial localization of EGFR autocrine systems is a critical factor for tissue development and homeostasis. It is difficult to analyze these systems, however, because they are both self-contained and recursive. To understand how cellular parameters influence autocrine activity, we investigated …
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Loss of Gprc5A Enhances Survival In Normal and Malignant Lung Epithelial Cells By Eliciting Persistent Stat3 Activation Induced By Autocrine Lif
… mice also exhibited autocrine Lif-mediated Stat3 activation. Treatment of <em>Gprc5a</em><sup>-/-</sup> cells isolated from normal and tumor tissue with AG490, a Stat3 signaling inhibitor, or with dominant negative Stat3(Y705F) increased starvation-induced apoptosis …
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Autocrine prolactin signaling in breast cancer cells leads to metabolic changes and therapeutic opportunities for anti-tumour and anti-bone metastatic treatment
… There is growing evidence for a role of autocrine prolactin (PRL) signalling in breast cancer progression, as well as for a role of prolactin in breast cancer-associated bone metastasis. The role of simvastatin in impairing the progression of cancer has also been reported. In this thesis, …
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Autocrine mechanisms of action of insulin-like growth factor-I (IGF-I) and hormonal regulation of expression of IGF-finding proteins in mammary epithelial cells
… of bovine mammary epithelial cells through an autocrine and/or paracrine pathway, several cell lines were developed expressing an ovine exon-2 containing IGF-I cDNA under the control of the mouse mammary tumor virus-long terminal repeat (pMMTV-IGF-I), early simian virus (pSV40-IGF-I), and …
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Localized HB-EGF signaling and Connexin43 decrease in the myocardium
… signaling can affect tissue remodeling through autocrine and paracrine mechanisms. Recent evidence indicates that hypertrophic signaling in cardiomyocytes is induced through transactivation of the epidermal growth factor (EGF) receptor by heparin-binding EGF (HB-EGF). Here it is shown that …
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Quantitative analysis of cytokine-induced hepatocellular death in the context of hepatotoxic therapeutics
… Initially, we examined the role of autocrine and intracellular signaling pathways in governing the synergistic induction of hepatocyte apoptosis by the cytokine tumor necrosis factor-a (TNF) in the presence of Adv infection in a primary rat hepatocyte cell culture model. We …
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System to study colony-colony interactions in embryonic stem cells
… (ESCs). Recent studies suggested that different autocrine factors exist in murine ESCs (mESCs) and can influence their self-renewal and proliferation, predominantly in deficiency conditions. These observations were investigated based on a comparison of different groups of mESCs that were plated …
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The roles of vitamin D in cutaneous wound healing: In vitro and ex vivo studies of the effect of 1,25(OH)2D3 and its precursors on human dermal fibroblasts and epidermal keratinocytes in cutaneous wound healing
… to being target cells, have enzymes required for autocrine production of 1,25(OH)2D3. They can convert cholecalciferol to 1,25(OH)2D3 via 25-hydroxylase (CYP2R1) and 1α-hydroxylase (CYP27B1). Another enzyme, 24-hydroxylase (CYP24A1), regulates local levels by inactivating 1,25(OH)2D3. While recent …
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Studies of the mammalian ovarian endothelin system
… porcine ovaries, endothelin-1 (ET-1) may have an autocrine/paracrine role in follicular development. Endothelin-converting enzyme-1 (ECE-1) converts big endothelin-1 to ET-1. In situ hybridization was used to determine the ovarian compartment that synthesizes ECE-1. ECE-1 mRNA was detected in …
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Proto-oncogene Regulation by Growth Factors in Bone Cells
… they make an ideal system in which to study the autocrine effects of bone growth factors.</p> <p>Based on this work, MC3T3-E1 cells are now known to produce IGF-I, TGF-beta and IGF-II in descending order of abundance. These growth factors also act on MC3T3-E1 cells in an autocrine manner. IGF-I …
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