Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Auto-antibody"”.
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Humoral immunity in colorectal cancer : evaluation of the anti-p53 and anti-hTERT auto-antibody responses
… which the humoral system is able to mount an auto-antibody response. Cancer cells are subject to two key mortality barriers (M1 & M2) as described in the "2-hit" hypothesis which are overcome by p53 dysfunction (M1) and hTERT re-expression (M2). These two molecular events generate TAA which …
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Identification of Anti-Beta2 Glycoprotein I Auto-antibody Regulated Gene Targets in the Primary Antiphospholipid Syndrome Using Gene Microarray Analysis
Anti-Beta2-Glycoprotein I antibodies (anti-2GPI) are strongly associated with thrombosis in patients with primary antiphospholipid syndrome (PAPS). Anti-2GPI activate endothelial cells (EC) resulting in a pro-thrombotic and pro-inflammatory phenotype. In order to characterise EC gene regulation …
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Genomic investigation of primary immunodeficiency
… including increased susceptibility to infection, autoimmunity, autoinflammation, atopy and malignancy. The list of genes associated with these inborn errors of immunity continues to expand. However, the majority of patients clinically effected with PID still remain without a genetic diagnosis. In …
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Proteases in Staphylococcal Arthritis
… Polyclonal B-cell activation was illustrated by auto-antibody production and a 10-fold increase in total IgG and a 50% increase in total IgM. Specific antibody response was demonstrated since only mice infected with bacteria expressing SspB and V8 responded with anti-protease specific antibody …
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The role of donor CD4 T lymphocyte chimerism in lung transplant recipients
… have demonstrated that cellular and humoral autoimmune responses to ‘self’ antigens may play a causative role in the onset of BOS. Work from our research group has highlighted a novel mechanism for triggering autoimmunity following transplantation. In a murine model of chronic heart …
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Molecular and functional analyses of human synovial B-lymphocytes in rheumatoid arthritis
… which is involved in the generation of autoantibodies. An autoantibody is defined as "pathogenic" if it fulfills the Witebsky-Rose-Koch criteria for classical autoimmune diseases: definition of the autoantibody; induction of the disease by transfer of the autoantibody; and isolation of …
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MODULATION OF THE B-CELL REPERTOIRE IN RHEUMATOID ARTHRITIS BY TRANSIENT B-CELL DEPLETION
Although the role of B-cells in autoimmunity is not completely understood, their importance in the pathogenesis of autoimmune diseases has been more appreciated in the past few years. It is now well known that they have roles in addition to (auto) antibody production and are involved by different …
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Characterisation of the anti-inflammatory potential of ES-62 in autoimmune disease
… destruction/disruption commonly associated with autoimmune disorders. Consistent with this, there is increasing evidence supporting an inverse relationship between worm infection and Th1/17-based inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease, type-1 diabetes and …