Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Auto-antibodies"”.
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Apoptotic Cells, Anti-Phospholipid Antibodies, and Anti-Chromatin Antibodies in Autoimmunity
Antiphospholipid antibodies (APAs) are detected in various autoimmune diseases, such as antiphospholipid syndrome (APS) and systemic lupus erythematosus. In addition to their binding to negatively charged phospholipids, APAs often cross-react with other molecules. Their potential biological effects …
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Molecular analysis of decay accelerating factor as a potential susceptibility factor to developing treatment resistant extraocular muscle involvement in Myasthenia Gravis
Myasthenia gravis (MG) is an autoimmune disorder in which auto-antibodies directed at the acetylcholine receptors (AChR) of the neuromuscular junction (NMJ) block, alter or destroy their targets. The anti-AChR antibodies cause activation of the classical complement pathway leading to inflammatory …
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Quantification and Molecular Characterization of Anti-citrulline Antibodies in Rheumatoid Arthritis
Autoimmune diseases are believed to result from the inability of the immune system to distinguish self and non-self. Rheumatoid Arthritis (RA) is a systemic autoimmune disease that leads to joint destruction and affects more than 1.5 million adults (Centre for Disease Control). Auto-antibodies …
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Force-extension of the Amylose Polysaccharide
Myasthenia gravis (MG) is an autoimmune disorder in which auto-antibodies directed at the acetylcholine receptors (AChR) of the neuromuscular junction (NMJ) block, alter or destroy their targets. The anti-AChR antibodies cause activation of the classical complement pathway leading to inflammatory …
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Transglutaminase and peptidylarginine deiminase in the pathogenesis of autoimmune diseases
… a model for understanding the pathogenesis of autoimmune disorders. In CD, antibodies against transglutaminase 2 (TG2) and specific glutamine residues of gliadins have been identified. A similar situation is seen in rheumatoid arthritis with both anticitrullinated protein antibodies (ACPA) and …
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Investigation of the Serological Changes that Discriminate Asymptomatic Antinuclear Antibody Positive Individuals from Systemic Autoimmune Rheumatic Disease Patients
… Antinuclear antibody (ANA) associated Systemic Autoimmune Rheumatic Diseases (SARDs) are chronic rheumatic disorders associated with high morbidity. Many patients with these diseases have irreversible tissue damage at disease presentation. Current therapies aim to control symptoms and prevent …
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Studies of ADAMTS13 expression and activity in the kidney
… is either due to mutations (congenital TTP) or auto-antibodies (acquired TTP). The histopathological lesion is termed thrombotic microangiopathy and characterized by disseminated hyaline thrombi in the microvasculature of various organs including the kidney. The present study aimed to …
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Studies of EHEC and the complement system in renal diseases
… dysfunction due to complement mutations or auto-antibodies (atypical HUS, aHUS). EHEC is a non-invasive highly virulent bacterium. In order to gain access to the circulation it first damages the intestinal mucosa. The mechanism of damage and the bacterial factors involved were addressed. …
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MUTATION OF REGNASE-1 CAUSES PRIMARY IMMUNODEFICIENCY ASSOCIATED WITH AUTO-INFLAMMATORY DISEASE
… to infection. Some PID patients may also have autoimmune and autoinflammatory manifestations. In many cases, PIDs are monogenic disorders that follow Mendelian inheritance and mutations in more than 250 genes have been shown to cause PIDs. However, in the majority of PID patients the causative …
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Development of an efficient test for autoimmune disease using gold nanoparticles
… to the production of a number of cytokines and antibodies that are linked to the disease and its pathological effects. The released antibodies can be used as specific biomarkers for developing reliable diagnostic tests. Over the years, different approaches like the use of mucosal biopsy, genetic …
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A resonant mirror biosensor approach to understand antibody-antigen interactions in Guillain Barré Syndrome
… to nadir and is fatal in five percent of cases. Antibodies specific to several nerve components are frequently associated with clinical symptoms in GBS. These antibodies were found to be specific to various gangliosides and ganglioside complexes. It was also found that antibody reactivity to …
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Elucidating the Role of Antigen-presenting Cells in the Immunopathogenesis of the Porcine Reproductive and Respiratory Syndrome Virus
… the early appearance of non-neutralizing antibodies (within a week), a delayed induction of T cell immunity (2-3 weeks post infection), with neutralizing antibodies becoming detectable roughly 4 weeks post infection, correlating to the resolution of illness. We believe that specific …