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Showing 1 to 6 of 6 for “"Aurora kinases"”.
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Understanding the effect of allosteric regulation of Aurora kinases on inhibitor binding
Aurora kinase A and B regulate various signaling processes during mitosis, and their overexpression is associated with mitotic dysregulation and tumorigenesis. Many ATP-competitive inhibitors of Aurora kinases have been developed and are in various phases of clinical trials. However, the lack of …
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THE ROLE OF AURORA KINASE IN THE DEVELOPING MALE GAMETOPHYTE OF MARSILEA VESTITA
… mitotic division. I investigated the roles of aurora kinases in the formation and maturation of the blepharoplast. Three unique aurora kinase isoforms were found in the transcriptome of the male gametophyte, each with a unique N-terminal sequence and expression pattern. RNAi knockdowns of each …
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Novel combination strategies with Aurora Kinase Inhibitors: using pre-clinical data to guide clinical trial design
… strategies combining current drugs with aurora kinase inhibitors (AKI) in pre-clinical models and then to design a clinical trial to assess these in patients with bladder cancer. Particular interest was stimulated by the correlation between over-expression of aurora kinases (AKs) with …
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Novel Fluorescent Sensors for Dynamic Intracellular Signalling
… dependent kinase (CaMKII), protein kinase B, and aurora kinases. These experiments demonstrated that KCP-1 can be used in living cells to specifically monitor PKC activity. KCP-1 was simultaneously observed in single cells with other fluorescent probes, including indicators for the PKC activators …
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Identification and characterisation of FAM83 proteins as key regulators of CK1 protein kinases in cells: FAM83D recruits CK1α to the mitotic spindle for proper spindle positioning
… casein kinase 1 (CK1) family of Ser/Thr protein kinases and direct them to the distinct cellular sites in which the FAM83 proteins reside. FAM83 members mediate CK1 binding through their conserved DUF1669. In this capacity, FAM83 proteins may act as the A Kinase Anchoring proteins (AKAPs) of the …
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Biochemical Context Drives Inhibitor Selectivity in Aurora A Kinase
The Aurora family of mitotic kinases control events necessary for proper separation of chromosomes throughout mitosis. The family is highly conserved and structurally similar but differs in their activation pathways and interacting partners. For example, Aurora A kinase can be activated by …