Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Aurora B kinase"”.
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A Novel Function For Aurora B Kinase In The Regulation of P53 By Phosphorylation
<p>The mitotic kinase Aurora B plays a pivotal role in mitosis and cytokinesis and governs the spindle assembly checkpoint which ensures correct chromosome segregation and normal progression through mitosis. Aurora B is overexpressed in breast and other cancers and may be an important molecular …
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Validation of The Activation of Aurora B Kinase By Caenorhabditis Elegans to usled-Like Kinase and The Identification of Cyclin B3 As A Phospho-Specific Tlk-1 Interactor
… of research have confirmed that the conserved Aurora B/AIR-2 kinase is required for multiple mitotic events including the proper attachment of microtubules to kinetochores, activation of a checkpoint that monitors kinetochore-microtubule attachment, and separation of daughter cells during …
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Molecular mechanisms of kinetochore microtubule attachment
… of kinetochore-microtubule attachments, Aurora B kinase. The Astrin-SKAP-LC8 complex is essential for mitotic progression and directly associates with microtubules. Furthermore, the microtubule polymerization factor CLASP requires the Astrin-SKAP-LC8 complex to localize to kinetochores. …
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Histone Post-translational Modification Dysregulation Contributes to Toxicity in Amyotrophic Lateral Sclerosis Proteinopathy Models
… the pathology of C9orf72 ALS and identify Ipl1/Aurora B Kinase as a possible therapeutic target. We find that H3S10ph levels are significantly increased in both yeast and human <em>in vitro </em>models of C9orf72 ALS. Furthermore, we show that knocking down Ipl1 in yeast significantly improves …
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Mechanistic Insights into the Microtubule-Mediated Differential Modulations of Aurora B Substrate Structures for Accurate Chromosome Segregation
… must be stabilized. This process is regulated by Aurora B, the kinase subunit of the Chromosomal Passenger Complex (CPC). How Aurora B can distinguish between erroneous and correct attachments and selectively phosphorylate its key substrates in the right contexts remains poorly understood. The …
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Preventing aneuploidy and the consequences of failure
… yeast Saccharomyces cerevisiae. The conserved Aurora B kinase is found to be responsible for detecting, and attempting to correct, incorrect kinetochore-microtubule attachments during both meiotic divisions. The meiosis I-specific protein Maml is found to link sister chromatids in a …
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Changes in Kinetochore Structure and Molecular Composition in Response to Mis-attachment
… bringing MCAK and other KT substrates closer to Aurora B kinase for rapid and efficient correction of KT mis-attachments.
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RNA localizations of proteins that interact with the chromosome passenger complex
… ncRNAs through mitosis. It is understood that Aurora B Kinase, or AURKB, plays a role in the dispersal of the ncRNA Xist from chromatin in mitosis, but our experiments probed the mechanism of this interaction. Using fluorescent microscopy to visualize the location of both the ncRNA and the …
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Organization and regulation of outer kinetochore assembly
… of this pathway is regulated at least in part by Aurora B kinase activity. In contrast, the CENP-T protein forms a direct, CDK-dependent interaction with the Ndc80 complex, and this interaction is required for downstream recruitment of KNL1 and the Mis12 complex, resulting in a novel recruitment …
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The Multifunctional Kinase Bub1 Acts as a Signaling Hub for the Spindle Checkpoint
… BubR1 and Cdc20. Bub1 is also a serine/threonine kinase. The only two identified substrates are histone H2A and Cdc20. Bub1 phosphorylates histone H2A threonine 120, which is important in recruiting Sgo1 and Aurora B kinase to the kinetochore. Bub1 also phosphorylates Cdc20 serine 153. It was …
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Studies of Aurora and Polo Kinases During Cell Division in C. elegans
… Using C. elegans, we investigated the roles of Aurora and Polo kinases during the release of meiotic chromosome cohesion. We found that the Aurora B kinase AIR-2 is localized to sub-chromosomal regions representing the last points of contact between homologous chromosomes in meiosis I and …
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Characterization of a Novel Chromatin-Induced Mechanism that Couples Microtubule Disassembly and Nuclear Re-Formation
… step in this process is the inactivation of the Aurora B kinase by the Triple A-ATPase Cdc48/p97, which physically extracts the protein from chromatin at anaphase. Aurora B is the catalytic subunit of the Chromosome Passenger Complex (CPC), which promotes microtubule polymerization and spindle …
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Role of phosphatases in the end-on conversion process
… and KNL1-recruited PP1 - in counteracting Aurora B kinase during the end-on conversion process. I found that BubR1-recruited PP2A-B56 plays an essential role in the process, but KNL1-recruited PP1 does not. I also investigated whether the HEC1/Ndc80 N-tail is a critical substrate of Aurora …
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Identification and characterization of Sgo2 interactions - Insights into dynamic chromosomal localization, mechanism of cohesin protection and putative checkpoint function
… of hSgo2, (2) the catalytic activity of the aurora B kinase is essential to focus hSgo2 at centromeres, and (3) attachment of microtubules to kinetochores is not only necessary for the metaphase-specific re-localization of hSgo2 but also sufficient; pulling forces are not required. These …
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Identifying Mechanisms Of Resistance And Potential Therapeutic Targets For Pediatric Acute Myeloid Leukemia
… to the combination of araC and one of either the aurora A kinase inhibitor MLN8237, the aurora B kinase inhibitor AZD1152-HQPA, the Plk1 inhibitor BI6237, or the wee1 inhibitor MK-1775. It was found that MK-1775, in contrast to the other three agents, synergized with araC in antiproliferative MTT …
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Protein Phosphatase 1 at the Kinetochore Regulates Chromosome Segregation
… mediated by several centromeric and kinetochore kinases, including Aurora B. Protein Phosphatase 1 (PP1) plays a counteracting role to Aurora B to stabilize kinetochore-microtubule attachments and silence the SAC. The regulation of PP1 to modulate these functions, however, remains enigmatic. …