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Showing 1 to 10 of 10 for “"Aurora A kinase"”.
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Molecular Mechanism of Aurora-A Kinase in Human Oncogenesis
Aurora-A is a mitotic kinase, which regulates cell cycle progression through modulating centrosome function. Aurora-A expression is frequently altered in human malignancies. The discrepancy between overexpression and amplification suggests that elevated Aurora-A level is likely to be regulated also …
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Biochemical Context Drives Inhibitor Selectivity in Aurora A Kinase
The Aurora family of mitotic kinases control events necessary for proper separation of chromosomes throughout mitosis. The family is highly conserved and structurally similar but differs in their activation pathways and interacting partners. For example, Aurora A kinase can be activated by …
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Regulation der humanen Aurora-A Kinase und Identifikation potentieller Interaktionspartner
… spindle is the serine/threonine-specific protein kinase Aurora-A. However, only a few interaction partners and physiological substrates of Aurora-A are know to date and the function of this important kinase is only beginning to emerge. To gain further insight in the cellular function of Aurora-A I …
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Functional Regulation of Yap By Aurora A Kinase In Triple-Negative Breast Cancer
… development. In this study, we determined that Aurora A kinase acts as a positive regulator for YAP-mediated transcriptional machinery. Specifically, YAP associates with Aurora A predominantly in the nucleus. Activation of Aurora A can impinge on YAP activity through direct phosphorylation. …
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Differential Regulation of Iress In The Aurora A Mrna By Bfgf Through The Mtor Complex to rc2 Modulates Aurora A Kinase Expression
… and proliferation. One of those proteins is the Aurora A kinase. Aurora A kinase is a member of a small family of kinases that contribute to mitotic events such as centrosome duplication, separation, and maturation. Aurora A overexpression leads to genomic instability, which can contribute to …
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Disrupting the inhibitory Kappa B kinase (IKK) - Aurora A axis in cancer
… have been proposed including the mitotic kinase Aurora A, one of three serine/threonine kinases of the Aurora kinase family that mediate mitotic progression in cells. Aurora A kinase specifically has several roles in the cell cycle, regulating spindle formation/attachment, centrosome …
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Identifying and Targeting Molecular Deregulations In Uterine Leiomyosarcoma: A Role For Mtor Inhibition-Based Combination Therapies
… examined the possible contribution of tyrosine kinase receptor deregulation promoting mTOR activation, and unraveled a role for pS6RP and p4EBP1 as molecular disease prognosticators. The significance of mTOR activation in ULMS and its potential as a therapeutic target were further investigated. …
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Characterisation of ALADIN’s function during cell division
… the spatial regulation of the mitotic regulator Aurora A kinase. Without ALADIN, active Aurora A spreads from centrosomes onto spindle microtubules, which affects the distribution of a subset of microtubule regulators and slows spindle assembly and chromosome alignment. Interestingly, mutations …
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Investigating how ubiquitin-mediated proteolysis of AURKA contributes to its activity in the cell cycle
Aurora kinase A (AURKA) is a major mitotic regulatory kinase required for mitotic entry, the formation of a bipolar mitotic spindle, and the completion of cytokinesis. In recent years AURKA has been identified as an upstream regulator for many interphase functions such as cilia disassembly and …
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Identifying Mechanisms Of Resistance And Potential Therapeutic Targets For Pediatric Acute Myeloid Leukemia
… to the combination of araC and one of either the aurora A kinase inhibitor MLN8237, the aurora B kinase inhibitor AZD1152-HQPA, the Plk1 inhibitor BI6237, or the wee1 inhibitor MK-1775. It was found that MK-1775, in contrast to the other three agents, synergized with araC in antiproliferative MTT …