Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Auranofin"”.
-
Biochemical analysis of a potential drug target in the human protozoal pathogen Trichomonas vaginalis
… test its activity against known TrxR inhibitor, auranofin, using DTNB assay. Cell lysates of metronidazole susceptible and metronidazole resistant lines were also tested to see its activity against auranofin. Auranofin derivatives that were effective on E. histolytica recombinant TrxR were also …
-
Targeting The Redox System to Overcome Mechanisms of Drug Resistance In Chronic Lymphocytic Leukemia
… 2 (EZH2) in drug resistance, and whether use of Auranofin has any therapeutic potential in CLL. This study determined that TCL1/p53<sup>-/-</sup> had elevated expression of transcription factors which regulate mitochondria biogenesis and increase in mitochondria DNA copy number. Second, …
-
The role of TvTrxR in drug resistance and characterization of TvRad51 in homologous recombination in Trichomonas vaginalis
… drug screens have identified the compound, auranofin, as an effective agent against similar protozoans. The mechanism of inhibition by auranofin has been found to proceed through inhibition of the thioredoxin-based anti-oxidant pathway, targeting the enzyme thioredoxin reductase (TrxR). In …
-
Repurposing non-antimicrobial drugs to treat multi-drug resistant bacterial and fungal infections
… present study identified four approved drugs (auranofin, ebselen, simvastatin and celecoxib) that exhibited potent antimicrobial activity against multidrug-resistant bacterial and fungal pathogens. Notably, auranofin, an FDA-approved anti-rheumatic drug possessed excellent antibacterial …
-
Metabolic Manipulation of Glutathione as an Anticancer Therapeutic Target
… for anticancer effects in established tumours. Auranofin is a putative inhibitor of the thioredoxin system. HCT 116 p53-/- cells were resistant to auranofin at doses that HCT 116 p53+/+ cells were sensitive to, however concurrent exposure of auranofin and glutathione depletion through serine and …
-
Translational Frontiers for Chikungunya Virus: New World Epidemic, New Strains, New Therapeutic Targets
… and 16F16, as well as inhibitors EN460 and auranofin to PDI regulatory proteins endoplasmic reticulum oxidoreductin-1 (ERO-1) and thioredoxin reductase (TRX-R), respectively, all greatly reduced CHIKV replication in vitro; 16F16 likely caused misfolding of the envelope proteins and …
-
Synthesis, characterization, and anticancer evaluation of novel gold(I) phosphine thiolate complexes : solubility, cellular uptake, and cytotoxicity.
… anticancer agents. Inspired by the activity of auranofin and the limitations of existing platinum-based drugs such as cisplatin, this research sought to explore the therapeutic potential of systematically varied gold(I) complexes. Ten complexes, comprising two series with either …
-
Investigating the role of UDP-<i>N</i>-acetylhexosamine pyrophosphorylases in regulating <i>O</i>-GlcNAcylation in human disease
… the function of UAP1L1 in <i>in vivo</i> models. Auranofin was identified as a selective inhibitor against human UAP1L1 over UAP1 and fungal UAP1 homologues from a high-throughput screening campaign. Mechanistically, auranofin inhibits UAP1L1 through selectively and covalently modifying a …