Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Auditory hair cells"”.
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Gingko biloba extracts protect auditory hair cells from cisplatin-induced ototoxicity by inhibiting perturbation of gap junctional intercellular communication
… apoptosis and disturbance of GJIC. HEI-OC1 auditory cells were cultured and treated with cisplatin (50μM) and EGb (300μg/ml) for 24 h, and then analyzed by immunocytochemistry (Annexin V/ propidium iodide) and Western blots. The function of GJIC was evaluated by scrape-loading dye transfer …
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Characterization of the Key Mouse Cochlear Developmental Genes for Auditory Hair Cell Regeneration
<p>Mammalian inner ear cochlear auditory hair cells (HCs) and adjacent supporting cells (SCs) are believed to derive from the same progenitors during development. However, unlike SCs of nonmammalian vertebrates, mammalian cochlear SCs cannot be converted into functional hair cells (HCs) after …
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Design, Fabrication, and Validation of Membrane-Based Sensors
Hair cell structures are one of the most common forms of sensing elements found in nature. In humans, approximately 16,000 auditory hair cells can be found in the cochlea of the ear. Each hair cell contains a stereocilia, which is the primary structure for sound transduction. This study looks to …
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Tuning of the Active Hair Bundle
… upon a population of several thousand sensory hair cells to amplify and transduce acoustic, seismic, and kinesthetic signals. Each hair cell detects mechanical disturbances by means of its hair bundle, a motile organelle consisting of actin-filled, villous projections (called stereocilia) …
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Understanding Actin Dynamics and Its Regulatory Mechanisms in Developing Stereocilia
Stereocilia, the actin-based protrusions of auditory hair cells, are essential for converting mechanical stimuli into electrical signals. Their formation and maintenance require tightly regulated actin dynamics, including elongation and widening through filamentous actin (F-actin) incorporation. …
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Promotion of Hair Cell Fate by Atoh1 and MicroRNA-183 Family
Hair cells are the mechanoreceptors responsible for hearing and balance in the inner ear. Multiple factors cause hair cell loss including aging, noise exposure and genetic predisposition. A barrier to hearing restoration after hair cell loss is the inability of mammalian auditory hair cells to …
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The Mechanism and Effects of TNF-α on Apoptosis in Auditory Cell Line
… to reveal that TNF-α could induce apoptosis in auditory cell line and to investigate the role of nitric oxide (NO) in TNF-α-induced auditory cell death. UB-OC1 cells and zebrafish were exposed to TNF-α. Flow cytometry, terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end …
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Transfer Properties of the Hair Cell-Afferent Fiber Synapse
… process achieved by the chemical synapses of hair cells in the auditory periphery. Thus, the operation of the hair cell's presynaptic active zone is key to understanding auditory transduction. However, the lack of suitable experimental systems in which to investigate both the presynaptic and …