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Showing 1 to 5 of 5 for “"AtxA"”.
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Functional Characterization of Atxa, The Bacillus Anthracis Virulence Regulator
… transduction pathway that is dependent upon the AtxA protein. Intricate control of <em>atxA</em> gene transcription and AtxA protein function have become apparent from studies of AtxA-induced synthesis of the anthrax toxin proteins and the poly-D-glutamic acid capsule, two factors with important …
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Control of The Master Virulence Regulatory Gene Atxa In Bacillus Anthracis
… operon for capsule are positively regulated by AtxA, a transcription regulator with unique properties. Consistent with the role of <em>atxA</em> in virulence factor expression, a <em>B. anthracis</em> <em>atxA</em>-null mutant is avirulent in a murine model for anthrax. In batch culture, …
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Functional Similarity of Prd-Containing Virulence Regulators In Bacillus Anthracis
… anthracis </em>produces three regulators, AtxA, AcpA, and AcpB, that control virulence gene expression and are members of an emerging class of regulators termed “PCVRs” (Phosphoenolpyruvate-dependent phosphotransferase regulation Domain-Containing Virulence Regulators). AtxA controls …
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The Influence of The Pep-Pts and Other Metabolic Systems On The Master Virulence Regulator Atxa and to xin Gene Expression In Bacillus Anthracis
<p>AtxA, the master virulence gene regulator in <em>Bacillus anthracis,</em> is a PRD-containing virulence regulator (PCVR) as indicated by the crystal structure, post-translational modifications, and activity of the protein. PCVRs are transcriptional regulators, named for the regulatory domains …
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Roles of Small Rnas and Paralogous Proteins In Bacillus Anthracis Virulence Gene Regulation
… transcripts, whose expression is dependent upon AtxA, the master virulence regulator of <em>B. anthracis</em>. sRNA levels are highest during culture conditions that promote AtxA expression and activity. Stability of the sRNAs is unaffected in <em>hfq</em>-null mutants. Comparison of the …