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Showing 1 to 7 of 7 for “"Atropisomerism"”.
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Towards the synthesis of RP66453
… core contains a biaryl axis that displays atropisomerism. The natural atropisomer of RP 66453 is less stable than its diastereoatropisomer. To date there have been no reported syntheses of the natural product, and just one reported synthesis of the unnatural atropisomer. This thesis …
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The development and application of organocatalytic asymmetric epoxidation
… our group, we also report the emergence of atropisomerism of the traditionally tropos sp2C-sp2C axis contained within biphenyl systems, presumably caused by efficient stereochemical relays mediated by the α-substituent. Lastly, we were able to successfully apply our methodology in the …
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Synthesis of Biologically Active Tropolones and Stereochemically Rich Compounds via Cross-Coupling Reactions
… B virus and other human pathogens.</p> <p>Atropisomerism is a form of chirality arising from conformational restriction of chiral axes and has an essential role in many compounds including, but not limited to, chiral ligands, and pharmaceutical drugs. Structural aspect of tropolones such as …
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Studies on the Synthesis, Function, and Properties of Troponoids
… describes our efforts in understanding troponoid atropisomerism – probing the limits of the stabilizing influence of the scaffold on the rotation of appended groups. Here we discuss our use of a dimerized oxidopyrylium ylide in [5+2] cycloadditions to generate novel tropolone probes for studying …
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Efficient & Novel Approaches to Relay Chirality in the Synthesis of Planar Chiral Metallocenes
… propeller phosphine chirality and conformational atropisomerism. Using mainly two representative examples the first a 7,5–membered cyclic lactone and the second a 5,5–membered cyclic ether complex the origins of chirality were explored which indicated the central carbon chirality relayed its …
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Synthesis and Evaluation of Densely-Functionalized Troponoids
<p>Herein, we document our efforts to expand the scope of troponoid synthetic methodology towards densely-substituted scaffolds. This body of work has focused primarily on an oxidopyrylium cycloaddition/ring-opening strategy for the synthesis and biochemical evaluation of troponoids for assistance …
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SYNTHESIS OF PHARMACOLOGICALLY ACTIVE MOLECULES THROUGH BIOCATALYTIC APPROACHES: STUDY OF THEIR STEREOCHEMISTRY AND POLYMORPHISM BY MEANS OF SPECTROSCOPIC AND CRYSTALLOGRAPHIC METHODS.
Elagolix is the first non-peptide orally active gonadotropin-releasing hormone (GnRH) antagonist, approved for the treatment of sex hormone-dependent diseases, such as endometriosis and uterine fibroids. This PhD project was focused on this drug, studying its conformational features, and improving …