Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Atovaquone"”.
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Der Einfluß von Chemotherapeutika auf Replikation und Stadiendifferenzierung von Toxoplasma gondii
… Therapeutika sind Spiramycin, Clindamycin und Atovaquone. Um den Effekt der Therapeutika auf die Replikation und Stadiendifferenzierung von Toxoplasma gondii zu untersuchen, haben wir ein in-vitro Modell entwickelt. Die Ermittlung der durchschnittlichen Anzahl von Parasiten pro parasitophorer …
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Accelerating antimalarial drug discovery through repositioning
… was shown to have a similar killing profile to atovaquone inferring a similar mitochondrial mode of action, corroborated by fluorescence staining with the JC-1 mitochondrial probe. Taken together, emetine’s pharmacokinetic matching and synergy with atovaquone provide an exciting drug combination …
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Lead optimisation of dehydroemetine as an antimalarial option through drug repositioning and molecular modelling
… synergistic antimalarial drug combinations (atovaquone/proguanil). Drug interaction analysis performed using the validated CalcuSyn method found the antimalarial drug atovaquone to be synergistic with (-)-R,S-dehydroemetine at IC50, IC75 and IC90 values (Combination indices (CI): 0.88-0.89). …
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A cost analysis of the treatment of first-line uncomplicated malaria in the Tonga district of Mpumalanga
… artesunate combinations, pyronaridine, atovaquone-proguanil, co-artemether, halofantrine, amodiaquine, and mefloquine. It was found that sulfadoxinepyrimethamine was 5 times more cost-effective as first line therapy than chloroquine. Of the other modelled drugs, it was recommended that …
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Investigation of Dual Stage Acridones as a Potent Malaria Treatment
… resistance mechanism. Slight cross-resistance to atovaquone and ELQ-400 was seen in T13-resistant parasites, indicating that T13 may target the component of the electron transport chain pathway that inhibits the binding of ubiquinone to cytochrome <em>b</em>. Two previously reported mutations have …
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A pharmacokinetic and antimalarial efficacy evaluation of pyridodibemequines and their metabolites
… antimalarial synergy with dihydroartemisinin or atovaquone and additivity with methylene blue in CQS and CQR strains of P. falciparum. 43M1 or 47M1 with mefloquine or lumefantrine displayed in vitro antimalarial synergy in a CQS strain of P. falciparum; however, in a CQR strain, antagonism and …
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Supercritical fluid extraction of non-traditional matrices
… animal feed is a requirement in these studies. Atovaquone, a drug used in the treatment of aids related pneumonia, was successfully recovered from rat feed with supercritical CO₂. Drug recoveries of ≥ 90% were achieved with a range of drug concentrations from 0.03% to 1.1% in the feed. The …
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Elaboration of 4′-Phosphopantetheine Adenylyltransferase inhibitors and Benzoxaboroles as antimalarial agents
… to those targeted by known antimalarials like atovaquone whose action is along the mitochondrial electron transport chain. Compound 2/MM1-19 did not inhibit -hematin formation (IC50 =1541 µM) as seen by decreased peptides in the parasite culture. In summary, the proposed PPAT inhibitors …