Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Atmin"”.
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The genetic interactions of PKHD1 and ATMIN in autosomal recessive polycystic kidney disease (ARPKD)
… In mice, mutations in the transcription factor Atmin can present with an ARPKD-like phenotype with kidney disease similar to an early manifestation of ARPKD. Like the mouse gene Pkhd1, mutations in Atmin are associated with altered WNT/PCP expression. Previous work has suggested that Atmin and …
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Investigating WNT signalling in the lung
… mutant mouse lungs. Following this, WNT4 and ATMIN single and double knockdowns, as well as WNT11 and PKD2 single and double knockdowns, were performed in A549 cells to assess the interrelationship between these genes and to determine their functional effects in lung epithelial cells. Several …
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An in vivo study of novel genetic modifiers in autosomal recessive polycystic kidney disease (ARPKD)
… PKD and Wnt signalling genes, including Pkd1, Atmin and Vangl2. Interestingly, RNA-sequencing analysis also identified Aqp2, Foxf1 and Igfbp2 as novel Pkhd1 targets in the lung, as well as dysregulation of STAT3 signalling in Pkhd1T37M/T37M mice. Together, this data further highlights potential …