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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 5 of 5 for “"Atlastin"”.

  1. Testing roles of Hereditary Spastic Paraplegia genes in axonal endoplasmic reticulum modelling in Drosophila

    Riaz, AyeshaUniversity of Cambridge2021

    … mutations in HSP affect proteins of the spastin, atlastin, REEP and reticulon (RTN) families, which possess hydrophobic hairpin domains in the ER membrane to help confer curvature on tubular ER. Drosophila mutants lacking members of RTN and REEP families exhibit partial ER fragmentation in axons. …

    cambridge Repository record

  2. The interconnected roles of spastin and protrudin in endosomal sorting

    Kleniuk, JuliaUniversity of Cambridge2024

    … (HSP)- associated proteins, spastin (SPG4) and atlastin-1 (SPG3A), as essential for endosomal tubule fission. I investigated the functional interaction of spastin and protrudin and found that protrudin, an ER-associated adaptor molecule involved in anterograde membrane traffic, is a novel factor …

    cambridge Repository record

  3. Beyond membrane curvature: Clade 6 reticulons and their role within the plant endoplasmic reticulum

    Wojcik, StefanOxford Brookes University2021

    … formation, and ROOT HAIR DEFECTIVE 3 (RHD3/Atlastin/Sey1p) which is required for 3-way junction formation. The differential expression of these proteins induces changes in ER morphology, and morphological dysregulation has been associated with disruptions in overall cellular function. Within …

    oxford-brookes Repository record

  4. Characterising the roles of mammalian atlastins in the endoplasmic reticulum and beyond

    Zlamalova, EliskaUniversity of Cambridge2023

    … focuses on endoplasmic reticulum (ER) proteins atlastins (ATLs), particularly ATL1, as *ATL1* gene mutations cause the most frequent childhood-onset form of HSP. Using CRISPRi, I engineered ATL1 knock-down (KD) into the i<sup>3</sup> human induced pluripotent stem cells (iPSCs) and utilised …

    cambridge Repository record

  5. Testing roles of Hereditary Spastic Paraplegia (HSP) proteins in organization of axonal endoplasmic reticulum (ER) and ER-mitochondria contacts

    Ozturk, ZeynepUniversity of Cambridge2022

    … encode ER-shaping proteins: spastin (SPG4), atlastin (SPG3A), Receptor Expression Enhancing Protein 1 (REEP1/SPG31) and reticulon (SPG12). These proteins share a common feature of one or two intramembrane hairpin domains that can recognise or drive curvature of the ER membrane. In Drosophila, …

    cambridge Repository record