Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Athymic nude mice"”.
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The Interaction of Equol and Genistein on Estrogen Dependent Tumors and Bones in Ovariectomized Athymic Nude Mice
… growth and bone development in ovariectomized athymic nude mice. In the first study, the experiments were conducted to evaluate the effect of equol alone on the T47D human breast cancer cells and bone metabolism. At the physiological concentration levels, 100 nM equol stimulated the T47D cell …
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Food processing modulation on breast cancer
… from stimulating MCF-7 tumor growth in athymic nude mice, indicating that other bioactive compounds in soy can negate the estrogenic properties of isoflavones. The underlying signal transduction pathways to explain the protective effects of soy flour consumption were studied. …
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Immunohistochemical analysis of a panel of human and murine markers on xenografted human vaginal mucosa: a comparative study
Athymic nude mouse models have been extensively used to study biological behaviour of normal and diseased human tissues. In such models, immune-deficient mice act as hosts for cysts constructed from human material. A unique biocyst model that entails transplantation of human vaginal cysts into …
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THE ROLE OF TETRASPANIN-8 IN ASTROCYTE ELEVATED GENE-1 MEDIATED PROGRESSION OF HEPATOCELLULAR CARCINOMA
… of orthotopic xenografts in the livers of athymic nude mice. TSPAN8 might be a useful diagnostic marker and potential therapeutic target for HCC. These findings indicate that upregulation of TSPAN8 might be an important event in mediating the oncogenic function of AEG-1.
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Gene Therapy for Osteosarcoma : "In Vitro" Characterization of Five Tumor Cell Lines and Development of Treatment Models "In Vivo"
… were used to develop a series of experiments in athymic nude mice to investigate the utility of gene therapy for the treatment of experimental osteosarcomas. Subcutaneous implants of mixtures of tumor cells and HS-tk vector producer cells (vpc) resulted in the development of tumors which were …
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Reconstitution of a Multi-layered, Differentiated Cornea by HTERT-Immortalized Corneal Epithelial Cells Transduced with Thymidine Kinase Transplanted onto Denuded Mouse Corneas
… stem cell deficiency (LSCD) was established in athymic nude mice (n=75) using ethylenediaminetetraacetic acid (EDTA) and mitomycin C treatment followed by mechanical debridement of corneal and limbal epithelium. Immunofluorescence (IF) using Anti-Laminin and Propidium iodide (PI) was used to …
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Targeting Prostaglandin E2 Receptor EP2 for Treatment of High-Risk Neuroblastoma
… blocked the development of NB xenografts in athymic nude mice. Additionally, EP2 conditional knockdown prevented established tumors from progressing in vivo. Pharmacological inhibition of EP2 by our recently developed antagonist TG6-129 substantially suppressed the NB tumor growth in both …
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Near Infrared Fluorescent Choline Kinase Inhibitors for Cancer Imaging and Therapy
… functions as a competitive inhibitor of ChoKa. Athymic nude mice inoculated with human breast cancer xenografts were injected i.v. with trace doses of JAS239 for imaging studies. In vivo optical imaging of JAS239 accumulation delineated breast tumor margins, and the signal intensity was capable …
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Somatic cell gene therapy for diabetes mellitus: engineering a surrogate B-cell
… implantation of the manipulated AtT20 cells into athymic nude mice with streptozotocin-induced diabetes resulted in decreased plasma glucose concentrations. The cells formed vascularised tumours in vivo which were shown to contain insulin-secreting cells. To achieve proinsulin processing in …
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Mechanisms of IFN-gamma-mediated Resistance against Development of Toxoplasmic Encephalitis
… of reactivation of chronic infection in BALB/c mice. This strain of mouse is genetically resistant to T. gondii infection and establishes a latent chronic infection as do immunocompetent humans, and therefore provides an excellet model for this purpose. Our laboratory previously demonstrated …
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Exploiting Multi-Cell Type Cultures to Elucidate Tumor Cell Features That Impact Macrophage Phenotype
… in the TME of lung cancer xenografts grown in athymic nude mice. Using our platform, we evaluated ~80 NSCLC patient derived lines for their effect on mouse macrophage phenotype. We identified three main macrophage phenotypes across this panel of NSCLCs. To identify cancer cell biomarkers for …
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TDiscovery and Development of Novel Therapeutic Agents for Advanced Melanoma
… failure. <em>In vivo</em> testing on C57BL/6 mice bearing B16-F1 melanoma allograft and on double homozygous SCID (severe combined immunodeficiency) hairless outbred (SHO) mice or athymic nude mice bearing A375 human melanoma xenograft showed these two classes of compounds significantly …
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Genistein suppresses colon cancer metastasis through epigenetic regulations
… mechanism behind in an in vivo model. Male athymic nude mice were fed with western diet (W; calories%, fat 39%, carb 50%), W diet supplemented with 100ppm Gen (GL) or 500ppm Gen (GH) . After 16 weeks, all the animals were intrasplenically injected with metastatic human colon cancer cells …
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RNA Interference for Improving the Outcome of Islet Transplantation and Polymeric Micelle‑based Nanomedicine for Cancer Therapy
… research was focused on the study of polymeric micelle formulations for treating cancers. Two key elements were integrated in my research projects: development of polymeric micelle delivery systems; discovery of new therapeutics for better treatment of cancers.</p> <p>The project described in …
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Molecular mechanisms of bioactive compounds in fruits and vegetables that inhibit pancreatic cancer and their relationship with inflammation
… cancer using an orthotopic mouse model. Male athymic nude mice (6 wk old) were injected with BxPC-3 human pancreatic cancer cells directly into the pancreas and randomized into four treatment groups: (1) control (n = 14); (2) luteolin [84 mg/kg body weight (bw)] 7 times/wk for wk 1 and 5 …