Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 62 for “"Atherosclerotic plaque"”.
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The mechanics of atherosclerotic plaque rupture
Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1992.
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Detection of periodontal bacteria in atherosclerotic plaque
… of latent bacterial species present in atherosclerotic plaque tissue from the carotid artery. Immunohistological examination of the atherosclerotic plaque tissue revealed widespread localisation of the bacterial cell wall constituent peptidoglycan (PGN). Targeted PCR amplification of the …
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Classification of atherosclerotic plaque vulnerability by mechano-radiomics
… resonance (MR) images can help evaluate carotid plaque vulnerability better than conventional MR methods. Hemodynamic forces have long been associated with the destabilization of developed plaques near regions of complex blood flow e.g., the carotid bifurcation, which results in high wall shear …
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A Novel Quantitative Mechanical Test of Atherosclerotic Plaque Stability
<p>Atherosclerotic plaque rupture is a major cause of myocardial infarction and stroke. The adhesive strength of the bond between the plaque and the vascular wall, measured as local energy release rate, G, was used for quantitative plaque stability estimation in mouse models. Towards the long-range …
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A Fluid Structure Interaction Model Of Intracoronary Atherosclerotic Plaque Rupture
Plaque rupture with superimposed thrombosis is the primary cause of acute coronary syndromes of unstable angina, myocardial infarction and sudden death. Although intensive studies in the past decade have shed light on the mechanism that causes unstable atheroma, none has directly addressed the …
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Three-dimensional Quantitative Magnetic Resonance Imaging of Carotid Atherosclerotic Plaque
… recent years, morphological characteristics of atherosclerotic plaque such as a thin fibrous cap, large lipid-rich necrotic core, intraplaque haemorrhage and ulceration have shown correlations with subsequent clinical events. High resolution, multi-contrast magnetic resonance imaging (MRI) can …
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Imaging atherosclerotic plaque inflammation with [18F]- fluorodeoxyglucose positron emission tomography
… the pathogenesis and outcome of atherosclerosis. Plaques containing numerous inflammatory cells, particularly macrophages, have a high risk of rupture, whereas those with fewer inflammatory cells are at lower risk. The current ‘gold standard’ technique for imaging atherosclerosis is x-ray contrast …
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Model parameter estimation of atherosclerotic plaque mechanical properties : calculus-based and heuristic algorithms
… pathways. This thesis focuses on studying plaque biomechanics because (i) there is a dearth of data on the mechanical behavior of soft arterial tissue yet (ii) it is the biomechanics that is able to provide invaluable insight into patient-specific disease evolution and plaque vulnerability. …
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The design, synthesis and evaluation of selective, non invasive imaging agents for atherosclerotic plaque.
… which could be used to non-invasively image atherosclerotic plaques via MRI. In order to achieve this, a library of peptide substrates designed to be substrate specific for either legumain or MMP-2/9 were synthesized. This was achieved via a combination of both solid and solution phase …
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Design and development of a multifiber shielded laser catheter system for removal of atherosclerotic plaque
Thesis: Ph. D., Harvard University--MIT Division of Health Sciences and Technology, 1987
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Impact of Percutaneous Transluminal Intervention on Vascular Hypoxia and the Role of Micro-calcifications on Atherosclerotic Plaque Rupture
<p>Atherosclerotic disease is initiated by cholesterol build-up beneath the endothelium, which evolves into a fibroatheroma, a lipid-rich plaque covered by a fibrous cap. Many of these plaques are considered as vulnerable, as they grow to occlude the luminal section of the artery (chronically …
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Age differentiation of rat smooth muscle cells : altered proliferation profile, cellular changes, and implications for atherosclerotic plaque destabilization
… shown that the elderly are at a higher risk for atherosclerotic plaque destabilization. The effect of aging on smooth muscle cells, a major cell type in the plaque, is central to the process of disease development yet is poorly understood. Therefore, we set out to study young and aged smooth …
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Global optimization methods for full-reference and no-reference motion estimation with applications to atherosclerotic plaque motion and strain imaging
… applied to ultrasound videos of carotid artery plaques. The velocity estimates are used to analyze plaque motion and produce novel non-invasive elasticity maps that can help in the identification of vulnerable atherosclerotic plaques.
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The role of image processing and artificial intelligence machine learning-based systems for unbiased evaluation of human coronary atherosclerotic plaque progression and vulnerability, and in response to pharmacotherapy
… tomography (OCT) can identify high-risk plaques and is a widely used surrogate efficacy marker for drug and device studies. For example, fibrous cap thickness (FCT) <75µm, minimum lumen area (MLA) <3.5mm2, lipid arc >180°, and presence of macrophages, calcific nodules, neovascularisation, …
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Smooth Muscle Cell Stress Response: Essential in Atherosclerotic Pathogenesis
… prominent role of smooth muscle cells (SMCs) in atherosclerotic plaque formation. SMCs undergo complex phenotypic modulation characterized by de-differentiation of SMCs and heterogeneously increased expression of markers for macrophages, fibroblasts, chondrocytes, and mesenchymal stem cells as …
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Fibromodulin and Dystrophin in Atherosclerosis: Novel roles for extracellular matrix in plaque development
… main underlying cause is atherosclerosis, and in atherosclerotic plaque progression the structure, composition and integrity of a dynamic extracellular matrix (ECM) is one very important factor. This thesis discusses the importance of the connection between the ECM and cells for atherosclerotic …
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Role of long non-coding RNA in atherosclerosis
… the vasculature characterized by development of plaque in the arterial wall. Advanced plaques may become unstable, carrying a risk of rupture or erosion and manifest as acute myocardial infarction. In patients with type 1 and type 2 myocardial infarction, mortality rates remain high; up to 15% …
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Role Of Substrate Stiffness In Driving Atherogenic Behavior In Macrophages.
… which is the most prominent immune cell type in atherosclerotic plaque due to its involvement in lipid clearance, apoptotic cell debris clearance and pro- or anti-inflammatory cytokine production. While the molecular mechanisms active in lesional macrophages have been extensively studied, the …
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Assessment of coronary artery plaque progression using 64 slice multi-detector computed tomography (MDCT)
… technique, and enable to detect of non-calcified atherosclerotic plaque and assess the plaque composition. Also coronary MDCT is an effective tool for assessment of serial change in plaque volume and then it would be used as a surrogate endpoint in clinical trials testing the efficacy of …
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Identification of potential clinical indicators of carotid plaque disruption using patient specific finite element modelling
… the arterial wall may provide an indicator of atherosclerotic plaque disruption. Many studies have used patient specific finite element models to estimate the stress environment in atherosclerotic plaques, attempting to correlate the magnitude of stress to plaque vulnerability. This thesis …
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