Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 40 for “"Atherogenesis"”.
-
Platelet adhesion in atherogenesis
Platelets are known to play a key role in acute coronary events, such as myocardial infarction, associated with advanced atherosclerosis, but a number of papers have recently been published suggesting that platelet adhesion may initiate atherosclerotic lesion formation. The proposed research aimed …
-
Role of Sodium Arsenite in Atherogenesis
… relevant concentrations of arsenic accelerate atherogenesis. The objective of this study was to elucidate the mechanisms of arsenic-induced atherosclerosis by (1) characterizing the time- and concentration-dependent effects of sodium arsenite [As(III)] on the development of atherosclerosis in …
-
Role of Sodium Arsenite in Atherogenesis
… relevant concentrations of arsenic accelerate atherogenesis. The objective of this study was to elucidate the mechanisms of arsenic-induced atherosclerosis by (1) characterizing the time- and concentration-dependent effects of sodium arsenite [As(III)] on the development of atherosclerosis in …
-
tissue-specific role of ATP binding cassette transporter A1 in atherogenesis
… (LDLrKO) background to study their roles in atherogenesis.
-
INVOLVEMENT OF LYSOSOMES IN SPONTANEOUS ATHEROGENESIS AND THE EFFECTS OF ESTROGENS
… however, their involvement in spontaneous atherogenesis or lesion progression is unclear. Estrogens have been reported to interact with lysosomes and are thought to provide a "protective" effect against development of atherosclerotic lesions. Analysis of lysosomes from sites predisposed to …
-
Factors That Influence Monocyte Differentiation and Hematopoietic Stem Cell Recruitment In Atherogenesis
… the vascular wall. One of the earliest events of atherogenesis is the adhesion of circulating monocytes to the injured vessel wall endothelial layer. Studies have shown that many factors influence monocyte activation and differentiation to macrophages in the context of atherogenesis. Studies have …
-
The Role of Dna Methylation and Hydroxymethylation In Smooth Muscle Cell Phenotypic Change During Atherogenesis
… and disruption of blood supply. During atherogenesis, lipid deposits, inflammation, and cells accumulate within the walls of arteries, ultimately leading to a buildup of fatty plaques and occlusion of the arterial lumen. In a multifactorial disease like atherosclerosis there are complex …
-
An electrochemical investigation of mass transfer and shear stress in pulsatile laminar flow : implications for atherogenesis,
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1973.
-
Mechanisms responsible for homocysteine mediated damage to human endothelial cells : the role of oxidative stress in atherogenesis.
Homocysteine (Hcy) has been identified as a primary risk factor for atherosclerosis as it induces endothelial cell (EC) activation/dysfunction and thus potentially initiating atherosclerotic plaque formation. There is accumulating evidence indicating a key role for oxidative stress in mediating Hcy …
-
Role of 11β-hydroxysteroid dehydrogenase type 2 in protection against inflammation during atherogenesis: studies in the Apoe-/- /11β-HSD2-/- double knockout mouse.
… of MR in cells of the vasculature, accelerates atherogenesis through promotion of a pro-inflammatory environment with increased endothelial cell expression of adhesion molecules and subsequent macrophage infiltration into plaques. DKO mice received either the MR antagonist eplerenone …
-
Development of a novel in vitro model to study the tryptic : endothelial cells, monocytes and flow
… use in the study of early molecular events of atherogenesis. In this work, we focused on how endothelial dysfunction, specifically mediated by disturbed flow from atherosusceptible regions of the vasculature, is both communicated to recruited monocytes as they reside in the subendothelial …
-
The Role of GM-CSF/IL-3/IL-5 Receptor Common β Subunit (CBS) in Hematopoietic Stem and Progenitor Cell (HSPC) Expansion, Monocytosis and Atherosclerosis
… suggest that CBS signalling could contribute to atherogenesis by promoting myeloid expansion. To investigate the role of CBS in the cholesterol driven HSPC expansion and monocytosis during atherogenesis, we generated Apoe-/-Cbs-/- mice through cross-breeding and transplanted Low-density …
-
Clonal haematopoiesis of indeterminate potential and the role of inflammation in its association with atherosclerosis
… CVD, with the presumption that CHIP promotes atherogenesis, but the reverse could be true, particularly as cardiovascular inflammation promotes bone marrow turnover. Moreover, murine studies inferring causality have often used models of CHIP with supra-pathophysiologic levels of mutant bone …
-
Atypical Mechanisms of Synthesis, Activation and Release of Interleukin-1β from Vascular Smooth Muscle Cells
… is a potent inflammatory cytokine implicated in atherogenesis and other vascular diseases. However, control of its activation and release has been predominantly studied in macrophages, with scant data on whether vascular smooth muscle cells (VSMCs) can release IL-1β. I investigated the …
-
Distant hemodynamic impact of local geometric alterations in the arterial tree
… mechanics have been suggested as the trigger for atherogenesis - non-laminar and/or unstable flow, flow separation, regions of higher/lower and/or oscillatory shear stress etc. While the precise mechanism by which these hemodynamic factors act is not yet clear, the fact that they correlate highly …
-
Differentially expressed genes in aortic cells from atherosclerosis-resistant and atherosclerosis-susceptible pigeons
… to be a major contributing factor in pigeon atherogenesis.</p><p>One hundred forty five pigeon transcripts were homologous to the chicken. However, the mitochondrial genes expressed in the pigeon were more closely related to non-domestic birds such as the turkey vulture and oriental stork. …
-
Cell-based sensors for quantifying cell health and disease progression in engineered systems
… a novel microfluidic platform to study atherogenesis in vitro that overcomes several limitations of existing models. This device emulates in vivo microenvironments by applying programmable spatiotemporal flow profiles observed from human patients directly upon cultured human cells. …
-
Measurement and validation of the nature of salivary adiponectin
… regulating insulin sensitivity, inflammation and atherogenesis. Levels of some hormones in saliva change in a fashion similar to that in plasma in response to a disease or physiological change. Since saliva is an easy to obtain biological fluid, measurements of salivary hormonal changes are …
-
Inflammatory markers as novel predictors of cardiovascular disease
… to be an important contributing factor in atherogenesis and the risk of atherothrombotic complications. Baseline measurements of some inflammatory markers are known to be predictive risk factors for future cardiovascular disease (CVD) events in prospective epidemiological studies. …
Page 1 of 2