Global ETD Search
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Showing 1 to 4 of 4 for “"Atg16"”.
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Structural and functional characterization of the autophagy proteins Atg5 and Atg16L1 and their interaction partners
… von Autophagosomvesikeln essentielle Atg12-Atg5~Atg16 Komplex assoziiert mit der wachsenden Isolationsmembran. Dieser Komplex oligomerisiert über die Coiled-Coil Domäne von Atg16 und diese Multimerisierung ist notwendig für das Wachstum der Isolationsmembran. In dieser Arbeit wurde das …
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Biochemical and Structural Characterization of the Atg8/LC3 Lipidation Pathway
… cascade including Atg7, Atg3, and Atg12–Atg5-Atg16 acting as E1, E2, and E3 enzymes, respectively. Atg7 initiates Atg8 conjugation by catalyzing their C-terminal adenylation and conjugation to the catalytic cysteine of Atg3. Ultimately, the Atg12–Atg5-Atg16 complex catalyzes Atg8 ligation to a …
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The study of two transmembrane autophagy proteins and the autophagy receptor, p62
… LC3-I in autophagy-impaired cells (ATG9 and ATG16 null cells) leading to formation of LC3-positive structures that can be misinterpreted as mature autophagosomes. Perturbations in the levels of p62 were seen to affect the formation of these LC3-positive structures in cells. This observation, …
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Characterisation of a novel interaction partner for Atg16L1 and its role in regulating autophagy
… conjugation events. Of particular importance is Atg16-like-1 (Atg16L1), which through its interactions with Atg5-Atg12, specifies the site of LC3 incorporation into the expanding autophagosomal membrane. In this study tools have been generated for the study and characterisation of Atg16L1 domains …