Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Ataxin-2"”.
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Characterization of Ataxin 2-Binding Protein 1 During Female Germ Cell Differentiation in Drosophila Melanogaster
The author has also published articles under the name "Omur Yilmaz Tastan" or "Ömür Yilmaz-Taştan".
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Yeast Ataxin-2 (Pbp1) Condensates Regulate TORC1 Activity and Autophagy in Response to Cellular Redox State
Yeast ataxin-2, also known as Pbp1 (Poly(A) binding protein-binding protein 1), is an intrinsically disordered protein that has earlier been implicated in stress granule formation, RNA biology, and neurodegenerative disease. However, the normal endogenous function of Pbp1 and ataxin-2 remains …
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Yeast Ataxin-2, A Protein with Many Friends: Identification of a Novel Role for Pbp1 in Mitochondrial Biogenesis
… such as cytochrome c oxidase components. Yeast-Ataxin2, Pbp1, is a poly(A)tail binding protein and a negative regulator of TORC1. Previous work showed that cells lacking Pbp1 in respiratory conditions exhibited mitochondrial dysfunction. I thus hypothesized that Pbp1 has an essential role in …
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RNA-binding Proteins and RNA-DNA Hybrids Regulate Repetitive DNA Stability in Health and Disease
… of repetitive loci. The RNA-binding protein Ataxin-2 (Pbp1 in yeast) regulates the stability of rDNA and yeast Ty1 retrotransposons. Interestingly, the human protein (ATXN2) undergoes trinucleotide repeat expansion in the neurodegenerative diseases spinocerebellar ataxia type II (SCA2) and …
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Genetic and biochemical analysis of the Drosophila melanogaster homolog of the human SCA2 gene
… filaments. Biochemical analysis of Datx2 and ataxin-2 (encoded by SCA2) reveal that both proteins physically assemble with polyribosomes, thus indicating that these proteins function in cytoplasmic RNA metabolism. These results suggest that SCA2/Datx2 function to regulate RNAs encoding …
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Rbfox1 Regulates mRNA Translation to Promote Germ Cell Differentiation
… RNA-binding Fox-1 (Rbfox1), also known as Ataxin-2 Binding Protein 1 (A2BP1), mutant females exhibit a germ cell differentiation defect that results in germline cystic tumors. The Rbfox genes encode several isoforms, many of which contain a highly conserved RNA recognition motif (RRM). …
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CRISPR-based approaches for proteinopathies of the central nervous system
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01