Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Ataxia telangiectasia mutated"”.
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How is Ataxia-Telangiectasia Mutated Protein Kinase Activated?
Ataxia-Telangiectasia Mutated (ATM) is a key protein kinase in the cell’s response to double-stranded breaks in DNA. This damage is detected by the Mre11-Rad50-Nbs1 (MRN) complex, which recruits ATM to the DNA. Upon activation, ATM phosphorylates a vast range of substrates, which triggers a …
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THE FUNCTION OF MRN (MRE11-RAD50-NBS1) COMPLEX DURING WRN (WERNER) FACILITATED ATM (ATAXIA-TELANGIECTASIA MUTATED) ACTIVATION
… cancer-prone and premature aging disease. ATM (Ataxia-Telangiectasia mutated) protein initiates a signaling pathway in response to DNA double strand breaks (DSBs). Genomic disorder ataxia-telangiectasia (A-T) is associated with defective ATM. WRN protein is involved in ATM pathway activation …
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Il cane come modello animale spontaneo di patologie neoplastiche dell'uomo: ene Ataxia-Telangiectasia Mutated (ATM) Nnella predisposizione al cancro ed importanza dei riarrangimanti genici dei geni Ig/TCR per la diagnosi e prognosi delle malattie linfoproliferative
… investigating the role of somatic mutations of Ataxia-Telangiectasia mutated (ATM) gene in predisposing to cancer in boxer dogs, are presented. The canine boxer breed may be considered an unique opportunity to disclose the role of ATM somatic mutation since boxer dogs are known to be …
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Double-Strand Break Repair Mechanisms in Human Embryonic Stem Cells
… kinase (PIKK) family, including Ataxia Telangiectasia Mutated (ATM), Ataxia Telangiectasia Mutated and Rad3-related (ATR) and the DNA dependent protein kinase (DNA-PK). The aim of this study was to define the mechanisms and important proteins involved in repair of human embryonic …
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Tyrosine 370 Phosphorylation of Atm Positively Regulates Dna Damage Response
<p>Ataxia telangiectasia-mutated (ATM) mediates DNA damage response by controlling irradiation (IR)-induced foci formation, cell cycle checkpoint, and apoptosis. However, how upstream signaling regulates ATM is not completely understood. Here, we show that upon IR stimulation, ATM associates with …
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The actin-binding protein Drebrin and its implications for Alzheimer's Disease using the model organism C. elegans
… be regulated by phosphorylation at Serine-647 by Ataxia telangiectasia mutated kinase and render nematodes more resistant towards chronic oxidative stress. The genetic cross of Aβ(1-42) and Drebrin unravelled that overexpression of Drebrin can ameliorate Aβ(1-42) aggregation and toxicity and that …
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ATM REGULATES THE NF-kB PATHWAY VIA RELA SER 276 PHOSPHORYLATION
Ataxia-Telangiectasia Mutated (ATM), a member of the phosphatidylinositol 3 kinase-like kinase family, is a master regulator of the double strand DNA break-repair pathway after genotoxic stress. Here we found ATM serves as an essential regulator of TNF-and RSV- induced NF-kB pathway. We observed …
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DNA Damage responses in plant stem cells
… leading to their specific killing via the ATAXIA TELANGIECTASIA MUTATED (ATM) and SUPPRESSOR OF GAMMA RESPONSE 1 (SOG1) genes. However, the components of the pathway leading to programmed cell death (PCD) in response to DSBs in plant stem cells are still unknown, and the in vivo DNA …
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The Role of Prolactin in the Cellular Response to DNA Damaging Agents
… Hsp90. The stability of Jak2 and both the total ataxia-telangiectasia mutated protein (ATM) and phospho-ATM appear to be dependent on functional Hsp90. Inhibition of Jak2 and ATM, with highly selective inhibitors (G6 and KU55933, respectively), abrogated prolactin enhanced viability, suggesting …
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The Protumorigenic Role of Caspase-8 in Neuroblastoma
… ERK signaling, which supports our hypothesis. Ataxia telangiectasia mutated kinase (ATM), an essential mediator in the DNA double strand break repair mechanism, is activated by chemotherapeutic treatments, radiation, and cellular stress. Caspase-8 has one consensus phosphorylation site that has …
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Brit1/Mcph1 Mediates The Dna Damage Response By Inducing P53 Stability and Promoting Atr Signaling
… breast tumor growth <em>in vivo</em>.</p> <p>The ataxia telangiectasia mutated and Rad3-related (ATR) kinase is a major mediator of DNA damage repair and replication stress response pathways. The key function of ATR is to induce S and G2 phase checkpoints through its interaction and …
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ATM plays multiple roles in crossover regulation during mouse spermatogenesis
… understanding how the DNA damage response kinase Ataxia Telangiectasia Mutated (ATM) might regulate crossover number, particularly in juvenile mice that exhibit reduced crossovers, referred to as the juvenile paternal age defect. During meiosis, ATM is known to negatively regulate SPO11-generated …
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Atm Signaling to Tsc2: Mechanisms and Implications For Cancer Therapy
<p>Ataxia telangiectasia mutated (ATM) is a critical component of the cellular response to DNA damage, where it acts as a damage sensor, and signals to a large network of proteins which execute the important tasks involved in responding to the damage, namely inducing cell cycle checkpoints, …
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Structural and Biochemical Investigation of the Molecular Mechanisms of DNA Response and Repair in Humans and <em>Escherichia coli</em>.
… of how full-length RPA contacts ssDNA. The Ataxia-Telangiectasia Mutated and RAD3-Related (ATR) mediated DNA damage checkpoint and nucleotide excision repair (NER) pathway are primarily responsible for repair of UV-C-induced photolesions in DNA. However, it is unclear how these two pathways …
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The role of ATM responding to DNA damage induced by Xrcc1 deficiency during oligodendrocyte genesis
Ataxia telangiectasia (A-T) is a prime example of hereditary disease about DNA damage signaling and repair protein deficiency. A-T is an autosomal recessive neurodegenerative disorder associated the defective ATM (Ataxia telangiectasia mutated) gene that is estimated to affect 1 in 40,000-300,000 …
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Identification of Intracellular Signaling Pathways Regulated by the TAO Family of Mammalian STE20p Kinases
… we show that TAOs may be substrates of the ataxia telangiectasia mutated (ATM) and ATM and Rad50-related (ATR) DNA damage kinases, as activation of TAO2 is diminished in cells from a patient with AT, which do not express ATM. These findings show that TAO kinases regulate critical events in …
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Widespread Phosphorylation of H2AX by Adenovirus Requires Viral Genome Replication and the E1B-55k or E4orf3 Proteins
… and NBS1. Each of the serine-threonine kinases ataxia telangiectasia mutated (ATM), AT- and Rad3-related (ATR), and DNA protein kinase (DNA-PK) likely contribute to H2AX phosphorylation, although ATR may be the largest contributor. Viral DNA replication appears to be the stimulus for this …
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Novel Roles of Replication Protein A Phosphorylation in Cellular Response to DNA Damage
… by DNA-dependent protein kinase (DNA-PK), ataxia telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) in homologous recombination (HR). HR and nonhomologous end joining (NHEJ) are 2 distinct DNA double-stranded break (DSB) repair pathways. Here, we report that DNA-PK, the core …
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Atm-/-Ung-/- Mice Present Reduced Levels of Switched Immunoglobulin Isotypes IgG1 and IgG3
… at serine-38 (S38), which is mediated in part by ataxia-telangiectasia mutated (ATM), facilitates the interaction of AID with apurinic/apyrimidinic endonuclease 1 (APE1), suggesting that ATM may function in BER through p-AID. However, mice possessing a knock-in mutation altering their serine-38 …
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Genotoxic effects of nano and bulk forms of aspirin and ibuprofen on blood samples from prostate cancer patients compared to those from healthy individuals: The protective effects of NSAIDs against oxidative damage, quantification of DNA repair capacity and major signal transduction pathways in lymphocytes from healthy individuals and prostate cancer patients
… was investigated by studying their effect on ataxia-telangiectasia-mutated kinase (ATM) and ataxia-telangiectasia and Rad3-related kinase (ATR) mRNA. ATM mRNA significantly increased after treatment with ASP B, ASP N and IBU N. ATR expression also increased after treatment with IBU B and IBU …
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