Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"Ataxia Telangiectasia Mutated (ATM)"”.
-
Il cane come modello animale spontaneo di patologie neoplastiche dell'uomo: ene Ataxia-Telangiectasia Mutated (ATM) Nnella predisposizione al cancro ed importanza dei riarrangimanti genici dei geni Ig/TCR per la diagnosi e prognosi delle malattie linfoproliferative
… investigating the role of somatic mutations of Ataxia-Telangiectasia mutated (ATM) gene in predisposing to cancer in boxer dogs, are presented. The canine boxer breed may be considered an unique opportunity to disclose the role of ATM somatic mutation since boxer dogs are known to be …
-
Tyrosine 370 Phosphorylation of Atm Positively Regulates Dna Damage Response
<p>Ataxia telangiectasia-mutated (ATM) mediates DNA damage response by controlling irradiation (IR)-induced foci formation, cell cycle checkpoint, and apoptosis. However, how upstream signaling regulates ATM is not completely understood. Here, we show that upon IR stimulation, ATM associates with …
-
ATM REGULATES THE NF-kB PATHWAY VIA RELA SER 276 PHOSPHORYLATION
Ataxia-Telangiectasia Mutated (ATM), a member of the phosphatidylinositol 3 kinase-like kinase family, is a master regulator of the double strand DNA break-repair pathway after genotoxic stress. Here we found ATM serves as an essential regulator of TNF-and RSV- induced NF-kB pathway. We observed …
-
DNA Damage responses in plant stem cells
… leading to their specific killing via the ATAXIA TELANGIECTASIA MUTATED (ATM) and SUPPRESSOR OF GAMMA RESPONSE 1 (SOG1) genes. However, the components of the pathway leading to programmed cell death (PCD) in response to DSBs in plant stem cells are still unknown, and the in vivo DNA …
-
Double-Strand Break Repair Mechanisms in Human Embryonic Stem Cells
… Embryonic stem cells show promise for treatment of a variety of diseases as well as for providing normal human tissue to conduct scientific research. A major obstacle for their application is that genomic instability arises in stem cells after prolonged cell culture. The most detrimental …
-
ATM plays multiple roles in crossover regulation during mouse spermatogenesis
… understanding how the DNA damage response kinase Ataxia Telangiectasia Mutated (ATM) might regulate crossover number, particularly in juvenile mice that exhibit reduced crossovers, referred to as the juvenile paternal age defect. During meiosis, ATM is known to negatively regulate SPO11-generated …
-
Atm Signaling to Tsc2: Mechanisms and Implications For Cancer Therapy
<p>Ataxia telangiectasia mutated (ATM) is a critical component of the cellular response to DNA damage, where it acts as a damage sensor, and signals to a large network of proteins which execute the important tasks involved in responding to the damage, namely inducing cell cycle checkpoints, …
-
Widespread Phosphorylation of H2AX by Adenovirus Requires Viral Genome Replication and the E1B-55k or E4orf3 Proteins
… and NBS1. Each of the serine-threonine kinases ataxia telangiectasia mutated (ATM), AT- and Rad3-related (ATR), and DNA protein kinase (DNA-PK) likely contribute to H2AX phosphorylation, although ATR may be the largest contributor. Viral DNA replication appears to be the stimulus for this …
-
Identification of Intracellular Signaling Pathways Regulated by the TAO Family of Mammalian STE20p Kinases
… we show that TAOs may be substrates of the ataxia telangiectasia mutated (ATM) and ATM and Rad50-related (ATR) DNA damage kinases, as activation of TAO2 is diminished in cells from a patient with AT, which do not express ATM. These findings show that TAO kinases regulate critical events in …
-
Novel Roles of Replication Protein A Phosphorylation in Cellular Response to DNA Damage
… by DNA-dependent protein kinase (DNA-PK), ataxia telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) in homologous recombination (HR). HR and nonhomologous end joining (NHEJ) are 2 distinct DNA double-stranded break (DSB) repair pathways. Here, we report that DNA-PK, the core …
-
Atm-/-Ung-/- Mice Present Reduced Levels of Switched Immunoglobulin Isotypes IgG1 and IgG3
… at serine-38 (S38), which is mediated in part by ataxia-telangiectasia mutated (ATM), facilitates the interaction of AID with apurinic/apyrimidinic endonuclease 1 (APE1), suggesting that ATM may function in BER through p-AID. However, mice possessing a knock-in mutation altering their serine-38 …
-
Characterizing Chromosomal Aberrations in Cells Deficient for Both ATM and MSH2
<p>Ataxia telangiectasia mutated (ATM) and mutS homologue 2 (MSH2) are important DNA repair proteins that participate in DNA repair pathways to maintain genomic integrity. Mice deficient for ATM and MSH2 mice are viable. However, <em>ATM<sup>-/-</sup></em> mice show growth retardation, neurological …
-
Targeting the DNA damage response protein ATR kinase in pancreatic cancer
… with the implementation of personalised treatment strategies, has the potential to improve the poor survival outcomes of pancreatic ductal adenocarcinoma (PDAC). Many common genetic alterations in PDAC augment replication-associated DNA damage, or replication stress (RS), which increases …
-
Investigation of the metabolic phenotype and metformin response of <i>ATM</i> heterozygous mice
… commonly prescribed for type 2 diabetes (T2D) treatment. However, 35% of patients experience adverse reactions to metformin and some patients that tolerate metformin do not respond with glucose lowering. The identification of biomarkers that inform of metformin response in patients is important as …
-
Epigallocatechin-3-gallate and tolfenamic acid induces apoptosis and growth inhibition in head and neck cancer : Involvement of NSAID activated gene-1
… recorded two decades ago in spite of various treatment trials. Therefore, preventive strategies are desirable, and much research is currently devoted to chemoprevention that aims to prevent HNSCC progression at an early stage. However, which chemopreventive agents are the safest and most …
-
Nuclear translocation of Gasdermin D (GSDMD) sensitizes chemotherapy through inhibiting PARP-1 in colorectal cancer
… DNA repair. After chemotherapeutic drug treatment induces full-length GSDMD nuclear translocation, GSDMD interacts with nuclear protein PARP-1 to dramatically inhibit its DNA Damage Repair-related function, to act similarly like the PARP inhibitor Olaparib. My findings confirmed that GSDMD …
-
How is Ataxia-Telangiectasia Mutated Protein Kinase Activated?
Ataxia-Telangiectasia Mutated (ATM) is a key protein kinase in the cell’s response to double-stranded breaks in DNA. This damage is detected by the Mre11-Rad50-Nbs1 (MRN) complex, which recruits ATM to the DNA. Upon activation, ATM phosphorylates a vast range of substrates, which triggers a …
-
ROLE OF ATM IN THE PATHOPHYSIOLOGY OF MAJOR DEPRESSIVE DISORDER (MDD)
Ataxia-telangiectasia mutated (ATM) is a serine/threonine protein kinase involved in the DNA damage repair (DDR) and many other cell processes. In neurons, ATM contributes to vesicles trafficking, neurotransmitter release, excitatory/inhibitory balance maintenance, the development of GABAergic …
-
Novel approaches to assess cellular interactions and their role in the pathology and treatment of lymphoproliferative disorders
… affecting the tumour protein P53 (TP53), ataxia telangiectasia mutated (ATM), or Notch receptor 1 (NOTCH1) genes, which are all more frequent in IGHV-unmutated disease. This work describes the development of techniques to characterise and quantify morphological responses to inhibitors, …
-
Distinct DNA Damage Signaling in the Brain Distinguishes ATLD, NBS, and ATR-Seckel Syndrome
… gene and the pathway in which it operates. Ataxia-telangiectasia (A-T) is the prototypical disease associated with DNA double strand break (DSB) repair deficiency and is characterized by severe neural pathology. A-T results from homozygous mutations that inactivate the ataxia-telangiectasia …
Page 1 of 2