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Showing 1 to 20 of 99 for “"Asymmetrische Synthese"”.
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Asymmetrische Synthese von Sulfonsäurederivaten
Sulfonic acids and its derivatives are an important class of organic compounds. There are many sulfonic acids and derivatives with interesting pharmacological properties (e.g. taurine). The main objective in this dissertation was the synthesis of various protected taurine-derivatives. Additionally, …
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Asymmetrische Synthese von 1-Aminocyclobutancarbonsäuren
… dieser Arbeit waren zunächst die Optimierung der Synthese der razemischen 2- Hydroxy-2,3,3-trimethyl-butansäure (4) sowie die Entwicklung einer effizienten Razematspaltung dieser Säure. Nach dem Aufbau des Glycinäquivalents sollte dieses für den stereoselektiven Aufbau 2-substituierter …
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Rhodium-katalysierte, asymmetrische Synthese: Ligandendesign und Methodik
The development of new and efficient catalysts is of utterly importance for the improvement of existing reactions and the discovery of new catalytic reactions. On the one hand this PhD thesis deals with the synthesis of novel, enantiopure diphosphines and phosphine-olefin-complexes bearing a …
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Asymmetrische Synthese von Dibenzylbutan- und Dibenzylbutyrolacton-Lignanen
Lignans are a wide spread class of natural compounds which mainly occur in plants as secondary plant metabolites. The term lignans is derived from Latin lignum (wood). Lignans are still very interesting and intensively investigated mostly due to their great variety of medical important …
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Asymmetrische Synthese von Tarchonanthuslacton und Pironetin-Bausteinen
The natural product Pironetin was isolated from the culture broths Streptomyces sp. NK10958 and Streptomyces prunicolor PA-48153 in 1994 and shows remarkably high antitumor and immunosuppressive activity. Aim of this thesis was an efficient asymmetric synthesis of the aforementioned natural …
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Asymmetrische Synthese von 2-Methyl-substituierten 1,3-Diolen
Nature employs dihydroxyacetonephosphate (DHAP) as a C3-building block for carbohydrate synthesis via enzyme catalyzed aldol reactions. Accordingly many groups focussed on broadening the scope of that enzyme catalyzed reaction. On the other hand a chiral, synthetic DHAP equivalent would not only be …
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Asymmetrische Synthese neuer planar- und zentral-chiraler Ferrocenylliganden
In this thesis we describe the enantioselective synthesis of mono- and di-ortho-substituted ferrocenyl diketones via our SAMP/RAMP-hydrazone method. Keystep is the stepwise diastereoselective ortho-metalation of 1,1'-bisbenzoylferrocene-bis-SAMP-hydrazone followed by trapping of various types of …
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Asymmetrische Synthese und stereoselektive Substitution allylischer Sulfoximin-funktionalisierter Homoallylalkohole
Enantiopure acyclic (E)- and (Z)-configured allylic sulfoximines have been synthesized from N,S-dimethyl-S-phenylsulfoximine and aldehydes via the addition-elimination-isomerization route. Titanation of lithiated (E)- and (Z)-configured allylic sulfoximines with Chlortrisdiethylanimotitan and …
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Asymmetrische Synthese funktionalisierter Homoallyl- und Homopropargylalkohole mittels der Sulfoximin-Route
This dissertation describes new methods of asymmetric synthesis of diastereomeric and enantiomeric pure allylic alcohols. Via the sulfoximine-route by Gais et al. new chiral homoallyllic alcohols were synthesized. Elimination of the sulfoximine-group lead to optically pure homopropargylic alcohols. …
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Asymmetrische Synthese von Beta-Aminosulfonaten, Beta-Sultamen und Gamma-Sultonen
An efficient asymmetric synthesis of beta-amino-cyclohexyl sulfonates, beta-sultams and gamma-sultones has been developed. The key step of the synthesis is the Lewis acid (zinkbromide) catalyzed aza-Michael addition of the enantiopure hydrazines (S)-1-amino-2-methoxymethyl-pyrrolidine (SAMP) or …
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