Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Asymmetric Cell Division"”.
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Synthetic In Vivo Reconstitution of Asymmetric Cell Division
Asymmetric cell division (ACD) is the process whereby one dividing cell gives rise to two daughter cells of differing fates. ACD is known to be controlled, at least in part, by protein complexes that reside asymmetrically at the cortex of dividing cells. These asymmetric domains are involved in …
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Quantitative Modeling of the Molecular Mechanism Controlling the Asymmetric Cell Division Cycle in <i>Caulobacter crescentus</i>
… model organism for studying regulation of cell growth, division and differentiation in prokaryotes. <i>C. crescentus</i> undergoes asymmetric division producing two progeny cells with identical genome but different developmental programs: the "swarmer" cell is flagellated and motile, and …
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HEM-protein regulates cell migration and asymmetric cell division during development of the ventral nerve cord in Drosophila melanogaster
Cell migration and asymmetric cell division are two of the key events during development of the nervous system. I have focused on a typical neuronal lineage, NB4-2→GMC-1→RP2/sib, in the ventral nerve cord (VNC) of the Drosophila embryo to investigate the regulation of neuronal migration and …
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ANALYSIS OF TWO NOVEL COMPLEXES THAT REGULATE NEUROBLAST SELF-RENEWAL AND ASYMMETRIC DIVISION IN DROSOPHILA MELANOGASTER
Drosophila neuroblast divides asymmetrically to produce a self-renewing neuroblast and a ganglion mother cell that is committed to differentiation. The balance between neuroblast self-renewal and differentiation is tightly controlled to ensure the proper development of the central nervous system. …
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Phosphorylation-based control of cellular asymmetry and the cell cycle in Caulobacter crescentus
Asymmetric cell division allows for better environmental adaptation and organismal complexity. Cells often divide by binary fission to form two identical daughter cells with similar developmental fates. However, a cell can also divide asymmetrically to form two daughter cells with different …
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Ric-8: un nuevo GEF con estructura tipo "armadillo"
… essential factor in neurotransmitter release and asymmetric cell division. Two different isoforms have been described in mammals, RIC-8A and RIC-8B; each possess guanine nucleotide exchange activity (GEF) on heterotrimeric G-proteins, but with different Gα subunits specificities. To gain insight …
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Establishing and Maintaining Cortical Asymmetry in <i>Drosophila</i> Neural Stem Cells
The asymmetric segregation of fate determinants is a conserved process by which differential cell fate can be acquired upon cell division. In this thesis we investigate how the asymmetric localisation of fate determinants is achieved in Drosophila neuroblasts (NBs, Neural Stem Cells). In particular …
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Role of ANLN in post ischaemic angiogenesis
… vessels are dynamically formed in Endothelial cell (EC) driven processes. The identification of new potential genes of interest in ECs can help to further understand the underlying mechanisms of angiogenesis and help develop new therapeutic strategies for cardiovascular disease. One such gene …
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LOCALIZED WNT3A-SOURCES INSTRUCT MITOTIC ORIENTATION: DISSECTING THE WNT3A-TRANSDUCTION MECHANISM COUPLED WITH NUMA MACHINERY
In multicellular organisms, morphogenesis and homeostasis of epithelial tissues require oriented cell divisions, which rely on the proper positioning of the mitotic spindle. Consistently, defects in epithelial polarity and spindle orientation are often coupled with loss of tissue architecture and …
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Spatiotemporal dynamics of cell division in intestinal homeostasis
… homeostasis is governed by fate choices of stem cells residing in the intestinal crypt base. This must involve niche-specific co-ordination of cell division to guarantee that epithelial cells divide at the right time and place. These mechanisms operate to ensure precise control of the numbers of …
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Uncovering novel actions of numb and aryl hydrocarbon receptor in the pituitary
… secretion, but can also include increasing cellular proliferation to meet greater demands. Taken together with the fact that these hormone producing cells differentiate in a spatial and temporal specific manner, the pituitary then is a convenient model to study cellular differentiation, …
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Regulation of polarised trafficking by Klp98A
… trafficking of cargo, a hallmark of living cells, relies on a polarised landscape of microtubule tracks. Here, I studied how the regulation of an endosomal motor affects polarised trafficking, using the asymmetric division of *Drosophila* Sensory Organ Precursor (SOP) cells as a model …
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Regulation of Asymmetric Cell Divisions in the Developing Epidermis
<p>During development, oriented cell divisions are crucial for correctly organizing and shaping a tissue. Mitotic spindle orientation can be coupled with cell fate decisions to provide cellular diversity through asymmetric cell divisions (ACDs), in which the division of a progenitor cell results in …
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The Role of Spindle Orientation in Epidermal Development and Homeostasis
… of spindle orientation is essential for driving asymmetric cell divisions (ACDs), which generate cellular diversity within a tissue. During the development of the multilayered mammalian epidermis, mitotic spindle orientation in the proliferative basal cells is crucial not only for dictating …
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Specification of Stem Cells and Niche During Hair Follicle Morphogenesis
<p>Adult stem cell (SC) behavior is tightly coordinated by the signals received from the "niche" - the microenvironment that the SCs reside in. Little is known about the role of the niche in SC specification during organ morphogenesis. In particular, the question of whether the niche exists prior …