Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Astrocytomas"”.
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Juvenile pilocytic astrocytomas: A search for prognostic markers
Introduction: Juvenile pilocytic astrocytomas are one of the most frequent central nervous system tumours occurring in children. While they are classified as WHO Grade I tumours, their natural progression is difficult to predict with some patients suffering significant morbidity and mortality …
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Executive Functioning In Child Survivors of Pediatric Cerebellar Astrocytomas
Twenty children who underwent surgery for CPA and were between the ages of eight and 16 years participated in the study. Each child was administered a multidimensional neuropsychological battery of EF, which consisted of the Delis-Kaplan Executive Function System, Wisconsin Card Sorting Test, and …
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An NMR study of human brain tumours: Phosphorus chemical shift imaging in vivo and high resolution proton spectroscopy of biopsy samples.
… were found to be higher in glioblastomas and astrocytomas than in normal brain. Pi/ATP and PCr/ATP were also high in astrocytomas. The pH of brain tumours ranged from alkaline to neutral, with meningiomas consistently having alkaline pH. A three dimensional localization sequence was written …
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Neural Stem Cells in Brain Tumor Development
Malignant astrocytomas are highly invasive and incurable brain tumors. Mouse models that genetically resemble the human disease are valuable tools in understanding the pathogenesis of these malignancies. We previously reported mouse models based on conditional inactivation of the human …
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The relationship between BRAF genetic alterations and the risk of tumour recurrence in Pilocytic Astrocytomas in children diagnosed at Red Cross Children's Hospital over a 33-year period
Introduction: Pilocytic astrocytomas (PAs), glial-derived neoplasms, are the most common central nervous system (CNS) tumours reported in the paediatric population. 1 PAs are circumscribed astrocytic gliomas associated with a favourable overall survival and thus regarded as low grade by the World …
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A systems approach to the different grades and progression of human astrocytoma
Astrocytomas are the most common glioma, accounting for about half of all primary brain and spinal cord tumors. Malignancy in these tumors ranges from the least aggressive pilocytic astrocytoma (WHO grade 1) to the most aggressive glioblastoma (WHO grade 4). Molecular biomarkers or signatures—i.e., …
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Characterizing and analyzing disease-related omics data using network modeling approaches
… phenotypes. Heterogeneity in high-grade astrocytomas also manifests as differences in clinical outcomes and significant efforts had been devoted to identify subtypes within high-grade astrocytomas that have large differences in prognosis. I developed an automated network screening …
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Short echo time single voxel magnetic resonance spectoscopy in the characterisation of childhood brain tumours.
… and pineal region tumours. A group of pilocytic astrocytomas were assessed for differences by location within the brain, for prognosis and for response to treatment. CONCLUSIONS The additional information given by short echo time MRS was useful in the characterisation of childhood brain tumours
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Continuous low dose rate irradiation of the rat brain
… for patients who are diagnosed with high grade astrocytomas and who undergo postoperative radiotherapy is of the order of 24 to 40 weeks. The course of radiotherapy administered to these patients takes up a considerable portion of their expected survival time. Therefore, any means of reducing …
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Evaluation of therapy for canine intracranial neoplasia using PAC-1, a novel and potent procaspase-3 activator
… intracranial neoplasms and high-grade human astrocytomas relative to normal brain tissues. Immortalized glioma cell lines show in vitro sensitivity to PAC-1 and radiation monotherapies at biologically relevant exposures. Murine gliomas appear to be sensitive to PAC-1 and radiation …
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The use of conventional and advanced magnetic resonance techniques in the assessment of primary brain tumours
… between rCBV values and tumour subtypes (astrocytomas, oligodendrogliomas and oligoastrocytomas) and therefore this technique was used in all subsequent rCBV measurements.
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The detection and role of human endogenous retroviruses in multiple sclerosis and other neurological diseases
… to establish their roles in MS and anaplastic astrocytomas. A method of detecting and quantifying levels of HERV-W env messenger ribonucleic acid (mRNA) and MSRV gag by reverse transcriptase polymerase chain (RT-PCR) reaction in a variety of cell lines was developed, with PCR products detected …
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Experimental brain tumors, dendritic cells and immunotherapy
Malignant astrocytomas are the most common primary tumors of the adult central nervous system. Surgical resection of tumor mass in combination with radiotherapy and chemotherapy is only palliative and there is a clear need for new and more effective therapeutic strategies. The aim of this study was …
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The Investigation of Targets for Therapy in Brain Tumours
… 2 secondary glioblastomas, and 4 grade III astrocytomas including medical history of the patients were analysed using hierarchical clustering analysis (HCA) and principal component analysis (PCA) employing multivariate statistics. Two distinct clusters of samples were found, which separated …
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Malignant Gliomas Originate From Neural Stem/Progenitor Cells and Are Maintained By Cancer Stem Cells
… of mutations that initiate malignant astrocytomas. Our highly physiological relevant mouse model also allowed us to address the question of how glioma is maintained in vivo: whether tumors are maintained by a subpopulation of cells with self-renewal capacity that supplies tumor bulk, …
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Analyzing The Role of Αvβ8 Integrin In Glioma-Induced Angiogenesis
… displayed pathological features of grade III astrocytomas, whereas β8 KO tumors resembled grade IV GBMs. KO tumors contained widespread edema and hemorrhage as well as pathological angiogenesis, as assessed by quantitation of microvascular density and blood vessel morphology. Additionally, …
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Paediatric brain tumours: The University of Cape Town experience from 1996 - 2017
… was 5.92 years. The commonest tumours were astrocytomas (n=114 patients; 20.3%), followed by medulloblastomas (incl. PNETs) (n=107 patients; 19.1%), and craniopharyngiomas (n=55; 9.8%). As expected, most patients referred and seen at RCCH/GSH were from the expected drainage area in the …
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Exploring Radiomics and Unveiling Novel Qualitative Imaging Biomarkers for Glioma Diagnosis in Dogs
… imaging biomarker of human low-grade astrocytomas, and demonstrates that the T2FMM is a highly specific biomarker for oligodendrogliomas —the first such imaging biomarker for GM to be discovered in veterinary research. Finally, Chapter 4 illustrates a structured radiomics pipeline for …
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Exploring Cancer Stem Cells (CSCs) pathways to design novel therapies for glioblastoma treatment
… usually developing from lower grade astrocytomas. Despite major therapeutic improvements made by combining neurosurgery, radiotherapy and chemotherapy, the prognosis and survival rate for patients with GBM remains poor (A.F.Carpentier and J.Y. Delattre. ;2005). There is a recognized …
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Molecular Genetic Analysis of Tumor Cells and Developmenet of RNA Interferance Therpy in Neurofibromatosis Type1(NF1)
… transformation of plexiform neurofibromas), astrocytomas, pheochromocytomas, and chronic myeloid leukemias of childhood. NF1 is notable for the existence of a gradual malignant degeneration of normal and/or benign tumor cells. Three pathological phenotypes of fibroblast cells, normal, benign …