Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 43 for “"Astrocytoma"”.
-
Metformin as a potential therapy for malignant astrocytoma
Background Glioblastoma Multiforme (GBM) is the most commonly occurring tumour of the central nervous system (CNS). Currently GBM is considered an incurable malignancy with patients experiencing abysmal life expectancies. Lack of progress in the discovery of novel treatments has led to the …
-
Epigenetic silencing of gene expression in paediatric astrocytoma
… about DNA methylation changes in paediatric astrocytoma. Recent investigations suggest that many tumours are initiated not only by genetic abnormalities, but also caused by epigenetic changes. DNA methylation is a key epigenetic mechanism that controls the regulation of gene expression. …
-
A Cell-Based Model to Study Factors that Drive Diffuse Astrocytoma Development
Secondary gliomas are an incurable form of brain cancer that are diagnosed in people at a median age of 45 years. Next-generation sequencing has found that secondary glioblastomas have a distinct genetic profile from the more common primary glioblastomas, which are diagnosed in people typically …
-
A systems approach to the different grades and progression of human astrocytoma
Astrocytomas are the most common glioma, accounting for about half of all primary brain and spinal cord tumors. Malignancy in these tumors ranges from the least aggressive pilocytic astrocytoma (WHO grade 1) to the most aggressive glioblastoma (WHO grade 4). Molecular biomarkers or signatures—i.e., …
-
Investigation of aspects of reactive gliosis in human astrocytoma cell lines:application for toxicity assessment
… the U251-MG, U373-MG and CCF-STTG 1 human astrocytoma cell lines were investigated for their ability to exhibit reactive-like changes following exposure to ethanol, chloroquine diphosphate, trimethyltin chloride and acrylamide. Cytotoxicity analysis showed that the astrocytic cells were …
-
Profiling medulloblastoma and juvenile pilocytic astrocytoma brain tumours in a South African paediatric cohort
… the generally less aggressive Juvenile Pilocytic Astrocytoma (JPA) with relation to their molecular biology and their clinical correlates to begin to address this gap and build capacity for further molecular-based studies in an African context. The study design in this thesis takes a systematic …
-
Neural Stem Cells in Brain Tumor Development
Malignant astrocytomas are highly invasive and incurable brain tumors. Mouse models that genetically resemble the human disease are valuable tools in understanding the pathogenesis of these malignancies. We previously reported mouse models based on conditional inactivation of the human …
-
Exploring the immunologic consequences of ATRX deficiency in glioma
… types is the adult-type glioma, IDH-mutant, Astrocytoma. It is known that ATRX mutation leads to increases in DNA damage, replication stress, and global epigenetic regulation at a cell level; however, less is known about the impact of ATRX mutation on immune signaling. Furthermore, little is …
-
Analyzing The Role of Αvβ8 Integrin In Glioma-Induced Angiogenesis
… the functional roles for αvβ8 integrin in astrocytoma-induced angiogenesis. These studies originate from our analyses of αvβ8 integrin in developmental brain angiogenesis. αv and β8 knockout (KO) mice develop brain-specific vascular phenotypes that resemble vascular pathologies observed in …
-
Evaluation of the mechanisms of neurotoxcity using metabolomic strategies
… neurotoxicity was investigated in human astrocytoma and neuroblastoma cellsusing proliferation assays coupled with LC-MS based metabolomics and transcriptomics techniques. Cells were treated with a range of cobalt concentrations between 0 and 200 μM. The metabolism of mephedrone at 100 μM …
-
Caratterizzazione proteomica di fluidi e tessuti in diverse condizioni fisio-patologiche
… the second study medulloblastoma and pilocytic astrocytoma pediatric brain tumor extracts have been compared. In both studies 2- DE analysis was coupled with high resolution tandem mass spectrometry (MS/MS). The proteomic characterization of the acid-insoluble fractions of saliva from preterm …
-
DEVELOPING SURFACE-MODIFIED LANTHANIDE-DOPED NANOPARTICLES AS A BRAIN TUMOR THERANOSTICS
Glioblastoma (GBM), a grade IV astrocytoma is highly aggressive and lethal. Recently, nano-based systems were widely used in GBM studies because of the ability to traverse the blood-brain-barrier successfully. However, there are still several major challenges. Lanthanide-doped nanoparticles …
-
The effect of specific phospholipids that may have a possible role in propagating or inhibiting glioma
… Glioma is categorized into three areas namely: astrocytoma, oligodendroglioma and astro-oligodendroglioma (mixture of both). In our day-to-day diet, the public consume phospholipids from various sources of food products including egg, milk, soybean, offal and some vegetables. Environmental …
-
Next-generation sequencing analysis and RNA editing in human brain and glioma
… percentages in nearly 400 glioblastoma and astrocytoma primary tumor, normal brain, and cell line samples. This study represents the first global view of differential editing across multiple brain regions and low- and high-grade astrocytoma. I identify relationships between expression of the …
-
NOVEL PERIPHERALLY DERIVED NEURAL-LIKE STEM CELLS AS DRUG DELIVERY VEHICLES FOR GLIOBLASTOMA
… (GBM) is an aggressive primary malignant astrocytoma characterized by infiltrating margins and angiogenesis. Standard treatment options such as radiation and chemotherapy have proven to be partially effective in treating GBM and its recurrence. Stem cells have been shown to migrate to …
-
Molecular mechanisms of cadmium toxic
… lines: HepG2 (human hepatoma), 1321N1 (human astrocytoma) and HEK 293 (human embryonic kidney) cell lines after 24hrs exposure to 5, 10 and 50 μM cadmium chloride (CdCl₂). The role of the Nrf2-Keap1-ARE pathway in the adaptive response of these cell lines to Cd exposure was examined, and the …
-
A clinicopathological and molecular genetic analysis of low-grade glioma in adults
… was shown for histological subtypes, oligoastrocytoma and anaplastic oligoastrocytoma, following the miRNA expression analysis in grade II and grade III tumors based on histology. Oligoastrocytoma presented a more similar profile to oligodendroglioma, but anaplastic oligoastrocytoma was …
-
The detection and role of human endogenous retroviruses in multiple sclerosis and other neurological diseases
… to establish their roles in MS and anaplastic astrocytomas. A method of detecting and quantifying levels of HERV-W env messenger ribonucleic acid (mRNA) and MSRV gag by reverse transcriptase polymerase chain (RT-PCR) reaction in a variety of cell lines was developed, with PCR products detected …
-
Development of a post-mitotic, neuronal-astrocytic cell system, for the prediction of acute neurotoxicity in humans
… were evaluated and compared with the CCF-STTG1 astrocytoma cell line, using a combination of basal cytotoxicity and biochemical endpoints. Using the MTT assay, the basal cytotoxicity data estimated the comparative toxicities of the test chemicals (chronic neurotoxin 2,5-hexanedione, cytotoxins …
-
The Role Of The Sparc Acidic Domain And Egf-Like Module In Glioma Migration, Invasion, And Signaling
… Rich in Cysteine (SPARC) is upregulated in all astrocytoma grades and increases tumor cell migration and invasion. It is thought that different domains within the protein may regulate SPARC functions, suggesting domain-specific targeting to inhibit invasion. To enhance our understanding of …
Page 1 of 3