Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 431 for “"Astrocytes"”.
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Morphological plasticity of astrocytes
… examine one type of glial cell, the astrocyte. Astrocytes are involved in the regulation of the metabolic and ionic microenvironment and may modulate synaptic activity or regulate synapse formation. Two experimental procedures were used to examine the plasticity of astrocytes to begin to …
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Silencing ITGB3 in Astrocytes
Astrocytes are brain cells that provide support to neurons, brain tissue structure, and can respond to brain injury. After traumatic brain injury (TBI), these cells can become reactive, changing their behavior, structure, and role as they migrate towards the injury site and form glial scars that …
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Astrocytes down-regulate microglial inflammatory responses
… been reported that soluble factors from cultured astrocytes are capable of suppressing microglial activation. However, brain injury affect not only microglia but astrocytes. Therefore, I examined how astrocytes in injury states modulate microglial activation. Astrocytes were treated with …
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Effects of Estrogens on Astrocytes Exposed to Stressors
… (single and combined estrogen) on viability when astrocytes were induced with stressors (epinephrine, cortisol, and low oxygen concentration). Cultured human astrocytes were treated with 17p-estradiol and equilenin, either alone or in combination. Following estrogen treatments, astrocytes were …
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Metabolic Changes in Astrocytes Following Traumatic Brain Injury
… [4], [5]. It is accepted that the role of astrocytes is highly significant in the response to TBI. The objective of this study was to improve and validate a previous flux balance analysis model of astrocyte metabolism developed by Martín-Jiménez et al. to study the effects of environmental …
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Astrocytes modulate microglial phenotype and dendritic cell-like properties
… an environment enriched by other cells, notably astrocytes. Therefore, to determine the effect of astrocytes on the assumption by microglia of the DC phenotype, microglia were treated with GM-CSF and LPS either in the presence or absence of astrocytes and assayed for the DC phenotypic marker …
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Mechanisms of Calcium Wave Initiation and Propagation in Astrocytes
<p>Glial cells display propagated waves of cytoplasmic calcium (Ca<sup>2+</sup>) mobilization that spread outward from an initiating cell to involve hundreds to thousands of surrounding cells. This intercellular communication system is thought to initiate and coordinate Ca<sup>2+</sup> dependent …
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Stressed Astrocytes: Insights on the Pathology of Alexander Disease
… an intermediate filament protein found in astrocytes in the central nervous system. The clinical presentations of AxD are diverse, ranging from onset in infancy to onset in early adulthood, and include seizures, psychomotor retardation, ataxia, and a variety of neurological signs related to …
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Role of JAK2 in the Proliferation of Activated Astrocytes
After brain injury such as trauma or stroke, astrocytes undergo proliferation and activation which is characterized by increased expression of GFAP. Although reactive astrocytes have some regenerative properties, the astrogliosis is thought to be a barrier to repair in the central nervous system. …
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Functions of Mediodorsal Thalamic Astrocytes in Cue-Based Learning
… Emerging data highlights the pivotal role of astrocytes in regulating synaptic transmission, with astrocytic calcium activity being linked to gliotransmitter release. Abnormalities in astrocytic calcium activity have been found to impair learning and memory, thus insights into their mechanism …
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Astrocytes Rescue Neuronal Health After Cisplatin Treatment Through Mitochondrial Transfer.
<p><strong>Abstract</strong></p> <p>Astrocytes rescue neuronal health after cisplatin treatment through mitochondrial transfer.</p> <p>Author: Krystal English</p> <p>Advisory Professor: Dr. Cobi J. Heijnen, Ph.D.</p> <p>Chemotherapy-induced cognitive impairments are associated with neuronal …
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Characterization of Hepatitis C Virus Infection of Hepatocytes and Astrocytes
… chapter, we characterized HCV interaction with astrocytes, one of the putative HCV target cells in the brain. HCV infection causes the central nervous system (CNS) abnormalities in more than 50% of chronically infected subjects but the underlying mechanisms are largely unknown. We showed that …
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Transcriptional Regulation of Matrix MetalloProteinase-3 in Rat Brain Astrocytes.
… IFN？^-, and gangliosides-activated cultured astrocytes obtained from rat brain. MMP-3 transcript and protein were increased by stimulation with LPS, IFN？^ and gangliosides. Promoter analysis revealed that sequences between -500 to start codon are important in induction of MMP-3. EMSA-based …
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Anti-Inflammatory Mechanism By Oxysterols In Cultured Rat Brain Astrocytes
… or interferon gamma(IFN-stimulated rat brain astrocytes with two oxysterols, 7-ketocholesterol and 22(R)-hydroxycholesterol. In LPS-stimulated astrocytes, both oxysterols suppressed inducible nitric oxide synthase expression and nitric oxide release as well as upstream signaling molecules …
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The role of blood-borne factors in triggering atypical astrocytes
… not well understood. Previously, we found that astrocytes lose expression of homeostatic proteins after mTBI, characterizing the changes in astrocytic protein expression as an "atypical astrocyte response." Yet, the upstream mechanisms that induce this atypical astrocyte response after mTBI have …
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