Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Astrocyte Activation"”.
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The Role of Astrocyte Activation in Infantile Neuronal Ceroid Lipofuscinosis
… fibrillary acidic protein: GFAP), a marker of astrocyte activation, in the thalamus, cortex, and cerebellum. Focal regions of GFAP upregulation were an accurate predictor of future sites of neuronal loss. Since astrocyte activation is both helpful and harmful to an injured CNS, the second aim …
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The Role of The Androgen Receptor Cofactor P44/Wdr77 In Astrocyte Activation
… astrogliosis. The p44/WDR77 is expressed in astrocytes and loss of p44/WDR77 expression in astrocytes leads to astrogliosis. Our results reveal a novel role of p44/WDR77 in astrocytes, which may explain the well-documented role of androgens in suppression of astrogliosis.</p> <p>While many of …
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Silencing ITGB3 in Astrocytes
Astrocytes are brain cells that provide support to neurons, brain tissue structure, and can respond to brain injury. After traumatic brain injury (TBI), these cells can become reactive, changing their behavior, structure, and role as they migrate towards the injury site and form glial scars that …
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Hyperinflammatory Experimental Cerebral Malaria: Coagulation and Glial Cell Activation in Plasmodium chabaudi Infection of IL-10-deficient Mice
… in the IL-10 KO brain post-infection, and the activation state of monocytes and microglia was increased. CD4+ T cells making IFN-γ were also identified in the brain, but remained localized within the vasculature and did not enter the brain parenchyma. Theses T cells were also found to be …
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hepatocyte growth factor inhibits glial scar formation and
… in vitro by cytokine treatment in primary astrocyte culture. Treatment of TGFβ1 led to astrocytic hypertrophy that was associated with dramatic upregulation of intermediate filament, GFAP (glial fibrillary acidic protein), which was evidently suppressed by HGF cotreatment in a …
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Mechanisms of Metastatic Spread of Breast Cancer to the Brain
… wall. These tumour cells then interact with astrocytes, the main supporting cells within the brain. The cerebral ECs are a key component of the blood brain barrier (BBB), a specialised and relatively impermeable blood vessel wall. Although this structure should protect the brain from tumour …
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ANIMAL MODELS FOR BEHAVIORAL CHANGES OR HEARING LOSS UPON ACUTE VIRUS INFECTIONS
… protein (GFAP) expression, indicating increased astrocyte activation, in the dentate gyrus and thalamus. In the Stat1-/- model of LASV infection, I found that 100% of survivors developed hearing loss post-infection, which correlated with severe damage to the cochlear nerve and CD3 positive …
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The neurotoxic effects of Manganese and the novel protective role of Drp1 in the autophagy pathway
… alterations in striatal TH density or microglial activation within the substantia nigra were observed at this timepoint, however increased astrocyte activation was identified. This study is the first to examine the effects of Mn exposure on mitochondrial function, autophagy flux and α-synuclein …
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Astrocyte: Neuron Interactions in the Juvenile Form of Batten Disease
… disorders of childhood. In all forms of NCL, astrocyte activation occurs early in the disease and precedes neuronal loss. However, in the most common juvenile form (JNCL), which is caused by a mutation in the Cln3 gene, this astrocyte response appears to be compromised. Since astrocytes are …
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Epigenetic Mechanisms in Blast-Induced Neurotrauma
… decline in memory. This change was observed in astrocytes and may provide a mechanistic understanding for a hallmark characteristic of the injury. Treatment with a specific enzyme inhibitor was able to mitigate some of the histone acetylation changes. This corresponded with reduced astrocyte …
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Clusterin: A Regulator of Glial Biology and Alzheimer’s Disease Pathogenesis
… features as drug targets. Microglia and astrocyte activation, first observed by Alois Alzheimer in 1907, have been reevaluated as potential contributors to AD progression rather than bystanders. Recent studies indicate that microglial dysfunction and neuroinflammation, likely play …
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Role of miR-4732-3p in breast cancer brain metastasis and brain metastatic tumor microenvironment
… TNBC cells significantly activated astrocytes. To determine how miR-4732-3p-activated astrocytes may activate further astrocytes and also BCBM cells, we conducted cytokine arrays to identify significantly dysregulated cytokines, and found that multiple cytokines including FLT3LG can …