Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 195 for “"Astrocyte"”.
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Astrocyte volume regulation during aging
Astrocyty, ako jeden z druhov gliových buniek, hrajú dôležitú úlohu v zdravo fungujúcej centrálnej nervovej sústave, ale takisto aj v jej patológii. Keďže jedna z ich funkcií je udržiavanie iónovej, neurotransmiterovej a vodnej homeostázy, astrocyty majú schopnosť regulovať svoj objem. Hypo- a …
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BDNF and Astrocyte TrkB.T1 Signaling as a Mechanism Underlying Astrocyte Synapse Interactions in Motor and Barrel Cortex
… the postsynaptic element, and a perisynaptic astrocyte process (PAP) that ensheathes the synaptic cleft. Increasing evidence demonstrates that PAPs are critical for synapse formation, stabilization, and plasticity. However, the mechanisms that govern the formation of tripartite synapses remain …
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Collective dynamics of astrocyte and cytoskeletal systems
… brain cells, and mechanical systems. Astrocytes are the studied non-neuronal brain cells, and the cytoskeleton is the studied dynamic, mechanical system consisting of various filamentous networks. The two filamentous networks studied herein are the actin cytoskeleton and the …
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Astrocyte-mediated immune modulation during mycobacterial infection
… prime resident immune-effector cells in the CNS; astrocytes however also regulate innate and adaptive immunity in CNS disease and injury. Astrocytes play a progressive role in maintaining the structural and functional integrity of the CNS while supporting neuronal function and participating in …
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Mechanism and Function of TrkB.T1 Astrocyte Expression
Astrocytes are the most abundant glial cell type in the central nervous system (CNS). Most astrocytes are born during the early postnatal period in the rodent brain and mature alongside neurons, demonstrating remarkable morphological structural complexity, and attaining maturity in the second …
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Novel mechanism in astrocyte gene regulation and function
… light on several novel mechanistic findings in astrocyte specific gene regulation and function by the NFI-X transcription factor which can be further extrapolated to astrocyte differentiation and glial tumor invasion. First, we cloned and analyzed human NFI-X3, a novel splice variant of the nfix …
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Death and the Construction of an Astrocyte Network
… death of another major cell type – the astrocyte – has rarely been studied. It is presently unclear whether astrocytes are subject to significant amounts of developmental death, or how it occurs. Here we address these questions using mouse retinal astrocytes as our model system. We show …
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The Involvement of Estrogen Receptors in Astrocyte Survival
… that estrogen receptors play in the survival of astrocytes when placed under stress with epinephrine as well as when treated with a well-known SERD. The results of this experiment indicated that treatment with estrogens did not offer any neuroprotection. Future studies should focus on differing …
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Astrocyte and vascular changes contribute to Alzheimer's disease
… (NFTs), neuronal loss, and the activation of astrocytes and microglia. One of the early indicators of AD is a global reduction in cerebral blood flow (CBF), which precedes significant plaque formation and cognitive decline. This persistent decrease in CBF, along with diminished oxygen and …
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Mechanisms of Astrocyte Contribution to Bortezomib-Induced Peripheral Neuropathy
… injury models have shown activation of both astrocytes and microglia following insult, research in other CIPN models has shown astrocytic activation in the absence of microglial activation. The central hypothesis of this dissertation is that the activity of astrocytes is correlated with …
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The role of estradiol in astrocyte and neuron communication
… longer considered passive players in the brain, astrocytes are now appreciated for their active role in neural communication. The “tripartite synapse” depicts the bidirectional communication between the presynaptic, postsynaptic neuron and the neighboring astrocyte. An important characteristic of …
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The Role of Astrocyte Activation in Infantile Neuronal Ceroid Lipofuscinosis
… fibrillary acidic protein: GFAP), a marker of astrocyte activation, in the thalamus, cortex, and cerebellum. Focal regions of GFAP upregulation were an accurate predictor of future sites of neuronal loss. Since astrocyte activation is both helpful and harmful to an injured CNS, the second aim …
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Astrocyte: Neuron Interactions in the Juvenile Form of Batten Disease
… disorders of childhood. In all forms of NCL, astrocyte activation occurs early in the disease and precedes neuronal loss. However, in the most common juvenile form (JNCL), which is caused by a mutation in the Cln3 gene, this astrocyte response appears to be compromised. Since astrocytes are …
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The Impact of Melanocortin Receptor Ligands on Astrocyte Signalling and Metabolism
… the CNS and explores their functional role in astrocytes. Astrocytes, once underestimated glial cells, are now recognised as crucial contributors to brain function. Although considered non-excitable cells, they increase their intracellular calcium ion levels in response to a stimulus or …
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The Role of Microglia and Astrocyte in Spinocerebellar Ataxia Type 1
… effect of polyQ expanded ATXN1 on astrocytes. Using the Lysm-Cre Ikkβflx/tlx line to assess the role of microglial activation in the transgenic ATXN1[82Q] mouse model of SCA1, I show that inhibition of microglial reactivity does not have a large effect on SCA1 disease pathology. …
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Role of Astrocyte Network in Edema after Juvenile Traumatic Brain Injury
… of the pathological hallmarks of jTBI is edema. Astrocytes play a key role in the edema process, and have been hypothesized that numerous astrocyte networks allow communication and propagation of edema and secondary injury spread. Two key astrocyte proteins are hypothesized to have a central role …
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Attributes of Astrocyte Response to Mechano-Stimulation by High-Rate Overpressure
… chronic brain damage that results from blast. Astrocytes have emerged as a potential therapeutic target because of their ubiquitous roles in brain homeostasis, tissue integrity and cognitive function. This glial subtype has a characteristic reactive response to mechanical trauma of various …
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The Role of The Androgen Receptor Cofactor P44/Wdr77 In Astrocyte Activation
… astrogliosis. The p44/WDR77 is expressed in astrocytes and loss of p44/WDR77 expression in astrocytes leads to astrogliosis. Our results reveal a novel role of p44/WDR77 in astrocytes, which may explain the well-documented role of androgens in suppression of astrogliosis.</p> <p>While many of …
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Role of N6-Methyladenosine (m6A) epitranscriptomic mechanisms in manganese-induced astrocyte inflammation
… neurons begin to die is a more complex inquiry. Astrocytes are considered the other major players, glial cells tasked with numerous homeostatic functions in the central nervous system such as blood-brain barrier regulation, reuptake and recycling of neurotransmitters such as glutamate and GABA, …
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Unraveling the molecular mechanism underlying ALS-linked astrocyte toxicity for motor neurons
… mice indicate that non-neuronal cells, such as astrocytes, play an important role in motor neuron degeneration. Consistent with this non-cell autonomous scenario are the demonstrations that wild-type primary and embryonic stem cell-derived motor neurons selectively degenerate when cultured in …
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