Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Asthma model"”.
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The Administration of P2Y12 Antagonist (P113) Attenuates Airway hyperresponsiveness and Airway Inflammation in an Ovalbumin (OVA) Specific Allergic Asthma Model
… antagonist, on airway inflammation in a mouse model of allergic asthma. MATERIALS AND METHODS: Sensitized BALB/c mice were intragastrically treated withP113(30mg/kg) 30 minutes before OVA challenge. Airway responsiveness (AHR), cell composition and cytokine levels in bronchoalveolar lavage …
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The role of autophagy in allergic inflammation: a new target for severe asthma
… 10 III.RESULTS 12 1. The establishment of severe asthma model 12 2. The level ofLC3 expression in severe asthma model 15 3. Electron microscopy results 16 4. Inhibition of autophagy improved AHR and airway inflammation 17 5. Knockdown of Atg 5 attenuates AHR and airway inflammation 20 6. Positive …
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A Novel Mouse Model of Asthma Induced by Cockroach
… important inhalant allergen and can make a mouse asthma model. However, mechanism underlying the CR-induced mouse model of asthma is not clear and the role of endotoxin contaminated in CR allergen remains controversial. Therefore, we evaluated the role of endotoxin and toll like receptor-4 (TLR-4) …
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RESPIRABLE SIRNA TARGETING AT THE NF-KB PATHWAY PROTECTS AGAINST INFLAMMATORY LUNG DISEASES
Asthma and chronic obstructive pulmonary disease (COPD) are common inflammatory pulmonary diseases. Cumulative evidences have shown the role of NF-kB signaling pathway in the pathogenesis of asthma and COPD. Ribosomal protein S3 (RPS3) is a subunit of NF-kB complex while receptor-interacting …
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The effects of ES-62 on DC maturation and effector function
… therapeutic role of ES-62 in two murine models of disease, namely collagen-induced arthritis (CIA) and asthma was investigated. In the CIA model, both prophylactic and therapeutic application of the parasite product in vivo has been shown to be beneficial, resulting in delayed onset and …
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Pathway into care for pediatric asthma
… by the physician because their respective models of the disease are different. Studies have also demonstrated that the patient may feel inferior to the health care provider and not share his or her model with the doctor for fear of being perceived as ignorant. The interaction between the …
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CD23's Role as a Negative Regulator of Allergic Disease: in vivo Effects of Murine CD23 Destabilization and Allelic Mutations
… finding was further confirmed in another disease model, namely the mouse asthma model. Mice overexpressing CD23 displayed suppressed allergic lung inflammation and reduced levels of IgE and Th2 cytokines and chemokines. Overall, the data provide a direct demonstration for CD23's role in regulating …
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Stem Cell and Biological Interventions to treat Allergic Airway Disease
… and allergic pathogenesis. This was probed in a model of pathogen driven immunomodulation (B. pertussis), and two models of therapeutic intervention namely immunisation (attenuated B. pertussis, BPZE1) or using a candidate cell therapy approach (mesenchymal stem cells, MSC). This work …
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Neurokinin-1 antagonism as a novel treatment for feline asthma : investigation of the role of substance p in airflow limitation and airway inflammation
… OF MISSOURI AT AUTHOR'S REQUEST.] Feline asthma, a chronic respiratory condition, results cough and/or episodic respiratory distress induced by airway hyperresponsiveness (AHR), airway eosinophilia, and airway remodeling. Homeostasis in the lung is partially maintained by the neuroimmune …
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Determining the Effects and Signaling Properties of β-Blockers in House Dust Mite-Driven Murine Models of Asthma
Asthma is a chronic inflammatory disease of the airways affecting more than 300 million people worldwide. Some characteristic features of asthma include airway inflammation, mucus hypersecretion, airway hyper-responsiveness and remodeling causing clinical symptoms such as recurrent coughing, …
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The role of Interleukin-4 induced gene 1 (IL-4i1) in allergic asthma and atopic dermatitis
… substances known as allergens. Both allergic asthma and atopic dermatitis (AD) are said to be induced by elevated levels of immunoglobulin E (IgE) and T helper 2 (Th2) immune cells and inflammatory associated cells such as eosinophils, mast, and basophils. Globally, asthma is affecting more …
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Mathematical Modeling and Analysis of Asthma Stability and Severity
<p>Asthma is one of the most common chronic conditions in the United States. Asthma affects about one in fifteen people. It affects children more than adults and blacks more than whites. People with asthma experience attacks of wheezing, breathlessness, chest tightness, and coughing. Asthma can be …