Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Association analyses"”.
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Association Analyses of Estrogen Receptor a Gene Polymorphisms with Bone Geometric Property at The Femoral Neck in Caucasian Nuclear Families
… most clinical importance of osteoporosis is its association with bone fragility. Bone geometry is an important risk factor for fracture, independent to BMD, and is genetically determined. However, genetic studies on bone geometry compared with BMD are scarce. Estrogen receptor a (ER-a) gene and …
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ROLE OF GENOMIC COPY NUMBER VARIATION IN ALZHEIMER'S DISEASE AND MILD COGNITIVE IMPAIRMENT
… in AD and MCI susceptibility, genome-wide CNV analyses were performed in participants from three cohorts: the ADNI cohort, the NIA-LOAD/NCRAD Family Study cohort, and a unique cohort of clinically characterized and neuropathologically verified individuals. Only participants with DNA samples …
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SIMPLIFIED TRAIT AND GENE DISCOVERY FOR DROUGHT RESILIENCE IN WHEAT USING EINKORN WHEAT
… phenotyping and high-resolution genome-wide association analyses. The findings establish a framework for translating adaptive alleles from diploid wheat into bread wheat, supporting the development of climate-resilient cultivars for water-limited environments.
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Analysis of the Appointment, Experiences, and Job Satisfaction of Leaders in Large Schools of Music
… gender and method of entry, showed a weak association. Analyses of the method of entry and the groups within the distribution of time variable showed a negative correlation between those appointed by administration and time spent on teaching, research/creative activities, and service. A …
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Identificazione e caratterizzazione di un gene associato all'asma ad insorgenza precoce persistente
… Society criteria. We performed linkage and association analyses by transmission/disequilibrium test and case-control analysis in the candidate region 12q13-24 already implicated in asthma etiology in multiple populations We selected a cutoff age of 13 years at asthma onset, to stratify the …
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High Precision Binary Trait Association on PhylogeneticTrees
… and host adaptation. Traditional genome-wide association study (GWAS) methods fail to account for shared evolutionary history, confounding association analyses. Microbial GWAS approaches emerged to address this, but modern methods often lack the statistical power to detect associations while …
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Attitudes toward the Effects of Privatization on the Employment System: A Study of Undergraduate College Students in Saudi Arabia
… own interests. The statistical significance and association analyses reveal that the effects of academic majors and province on respondents' attitudes toward promotion criteria, teaming, and management's nationality are indeed significant. In addition, gender, SES, living areas prior to college …
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Sequence capture as a tool to understand the genomic basis for adaptation in angiosperm and gymnosperm trees
… trees, and to leverage such data in genome-wide association analyses to find the genetic variants that underlie complex, adaptive traits in spruce and pine, as well as poplar. Results of this research will facilitate bridging the genomic information gap between trees and other organisms. …
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Introducing A Novel Method For Genetic Analysis of Autism Spectrum Disorder
… I first review previous studies on genetic association analyses of autism spectrum disorder. A large number of these studies fall into two categories: Genome Wide Association Studies (GWAS) and sequencing studies. Although GWAS are able to identify multiple common risk variants associated …
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Evolutionary forces shaping innate immune gene variation in a bottlenecked population of the Seychelles warbler
… how this variation is maintained by conducting association analyses investigating innate immune gene variation and its relationship with individual survival and malarial susceptibility / resistance. Environmental factors are also considered. By investigating the consequences of functional …
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Integrative Genetic and Epigenetic Studies to Identify Prostate Cancer Genes at Chromosomal 8p
… we did comprehensive germline and somatic analyses, including germline mutation screen in 96 probands of hereditary prostate cancer families, 10 common SNPs association analyses in sporadic PCa cases and controls, somatic copy number change analyses and promoter methylation test. It was …
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EXAMINING THE CONTRIBUTION OF GENETIC VARIANTS TO CARDIOMETABOLIC TRAITS
… tested using two-point linkage, single variant association, and gene-based analyses with 37 cardiometabolic phenotypes. Additionally, a detailed analysis of the performance of both two-point linkage and single variant association analyses was performed on Chromosome 3 with the trait adiponectin, …
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GENETIC CHARACTERIZATION OF THE ST. KITTS-ORIGIN VERVET MONKEY (CHLOROCEBUS AETHIOPS SSP.) AS A MODEL OF POLYGENIC OBESITY
… long been regarded as tentative. Phylogenetic analyses were perfomed using TNF putative promoter region nucleotide sequence, among the St. Kitts-origin vervet, and four other African-origin subspecies. Results show the St. Kitts vervet has significant sequence differences from the African Green …
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Next Generation Sequencing and Genome-Wide Association Studies to Identify Mitochondrial Genomic Features Associated with Diabetic Kidney Disease
… (SNPs) affecting mitochondrial function for association with DKD.<br/><br/>Targeted genome wide association analyses focusing on mitochondrial DNA (mtDNA) and nuclear genes involved with mitochondrial function were performed using DNA samples from the All Ireland / Warren 3 Genetics of …
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Genetic and molecular characterisation of metabolic subphenotypes and their contribution to type 2 diabetes aetiology
… This incorporated large-scale population genetic analyses of T2D and fine-scale intermediate traits, with targeted in vitro functional follow up of genes and variants of interest. Focused in vitro and genetic investigation of a single gene, MC3R, of which loss of function was previously thought to …
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DISSECTING THE POLYGENIC LANDSCAPE OF HUMAN COMPLEX TRAITS AND DISEASES IN A SOUTHERN ITALIAN COHORT
… public health. In the first part, genome-wide association analyses of quantitative traits showed overall consistency with findings from other European populations, while also revealing population-specific features, such as the persistence of strong-effect alleles at the HBB locus. We then …
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Genome-wide association study for sperm motility in pigs
A qualidade do sêmen de reprodutores suínos pode ser avaliada de acordo com vários critérios, sendo a motilidade espermática o mais utilizado e importante. A motilidade, essencial para a fertilização, refere-se ao movimento retilíneo dos espermatozóides. Apesar da importância da avaliação de …
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IDENTIFYING GENES THAT CONTRIBUTE TO TYPE 2 DIABETES SUSCEPTIBILITY IN CAUCASIAN AND AFRICAN AMERICANS
… this region we observed suggestive evidence of association with T2DM for SNPs within the genes NCOA5, CDH22, and PREX1. We aimed to evaluate these three genes in two independent Caucasian case-control populations. Seventy two SNPs were genotyped in 300 diabetic nephropathy patients and 310 …
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Genetic dissection of essential hypertension and familial intracranial aneurysm
… Hypertension Study. Two-point and multipoint analyses showed linkage of a 7 cM region to both hypertensive status and blood pressure phenotypes. A maximal multipoint Z-score of 2.2 for systolic blood pressure (SBP) was obtained proximal to the marker D5s1480. In light of the debate regarding …
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The effect of non-coding variants on gene transcription in human blood cell types
… size enables the identification of additional associations, also with low-frequency variants, and I compared my cell type specific eQTL results to results from an eQTL study performed on whole blood without cell type purification. Gene regulation is complex and relies on several layers of …
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