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Showing 1 to 20 of 30 for “"Association Constant"”.
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Synthesis of mixed ligand, water soluble square planar platinum (II) complexes and an investigation of their association with haematin and potential to inhibit the formation of synthetic malaria pigment
… planinum (II) complexes were synthesised, their association with haematin determined in 40 aqueous DMSO, pH 7.4 at 25°C and their ability to inhibit the formation of β-haematin (synthetic malaria pigment) was investigated. The compounds synthesised and investigated contained a platinum (II) ion …
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Characterization of alpha-cyclodextrin inclusion complexes with trans-cinnamic acid in an acid-based beverage system
… to host. H-NMR was used to determine the complex association constant, determine the chemical shifts of available protons, and yield a stoichiometry for the complex. The solid inclusion complex allowed for a physical formation of the complex, yielding further information in support of the complex …
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Part I. Molecular Tweezers: Synthetic Receptors for Nucleotide Bases. Part II. Molecular Self-Assembly: Design of a Helical Aggregate
… complexation of 9-propyladenine by 28, a association constant of 25,000 M$\sp{-1}$ was measured. The nucleoside selectivity of 28 was also studied. Studies suggested that the unique microenvironment provided in 28 altered the preference of the carboxylic acid for nucleotide bases and for …
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Cooperativity of ligand binding as a function of monomer-dimer equilibrium Parameters and Acceptor Concentration
… selecting the appropriate family of equilibrium constants from this general scheme. Each system is then characterized in terms of Hill coefficient dependency on alterations in values of equilibrium constants and total acceptor concentration. This method permits comparison of predicted …
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Synthesis and Properties of Selectively Modifiable Cyclodextrin Analogues
… dye 8-anilino-1-naphthalene sulfonate with an association constant of 38 +/- 10 M-1. In addition, the synthesis of a monosaccharide cyclotrimer and a disaccharide cyclodimer is presented that were demonstrated to complex 2,4-hexadiyne-1,6-diol with association constants of 8.8 +/- 1.5 M -1 and …
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Part I. Molecular tweezers: Role of preorganization and synthetic progress toward a water soluble tweezer. Part II. Progress towards an empirical approach to carbohydrate recognition
… NMR binding studies indicate an increase in the association constant (K$\sb{a}$) with the increase in rigidity. The effects of increasing rigidity are additive with $\rm\Delta\Delta G\sp\circ\sb{13\to11}=2\Delta\Delta G\sp\circ\sb{13\to12}$ = 1.8 kcal$\cdot$mol$\sp{-1}$. Thus, the enforced syn …
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Thermodynamically Driven (Reversible) End-Capping of Pseudorotaxanes to Produce Rotaxanes
… observed using 1D and 2D ¹H NMR spectroscopy. An association constant of 110 M⁻¹ was determined by integration for the pseudorotaxane from the ammonium hexafluorophospate salt and dibenzo-24-crown-8. The new guest species were endcapped in situ as trityl ethers to form new thermodynamically stable …
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Platinum Complexes and Zinc Finger Proteins: From Target Recognition to Fixation
… tryptophan (Trp), showed an enhanced binding constant for platinated nucleobases. This was confirmed by density functional theory (DFT) calculations as the difference in energy between the HOMO of Trp and the LUMO of the nucleobase was smaller for the platinum complex. The studies were …
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Cryptophane Derivatives as Gas Sensors and Hyperpolarized Xenon-129 Biosensors
… of a radiometric assay for measuring the association constant of radon binding to a discrete molecular species, KA = 49,000 ± 12,000 M-1 at 293 K. For cancer detection by hyperpolarized 129Xe MRI, a new folate-conjugated cryptophane biosensor was developed that targets folate receptors …
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s-Triazine-Based Self-Assembling Information Molecules
… via NMR titration experiments. The value of the association constant for the first generation homo-sequence dimers was within the range expected for a single hydrogen bond. This suggests that, in the solution state, these systems form aggregates rather than canonical duplex structures. However, …
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Helical Pitch, Hydrophobic Binding, Chiral Templation, and Supramolecular Chelation of M-Phenylene Ethynylene Foldamers
… of acetonitrile. It was found to have an association constant with (-)-alpha-pinene of 1.4 +/- 0.09 x 106 M-1 in 90% water in acetonitrile, which was much higher than predicted from linear extrapolation in previous studies of less soluble oligomers. A mPE oligomer with a helicene moiety in …
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Hapten Binding by Lymphocyte Surface Immunoglobulin and the Subsequent Implications for Affinity Maturation
… to smIg affinity. The functional or observed association constant resulting from multi-determinant-smIg interaction (avidity) may provide a degree of enhancement in antigen binding as to obscure the selective advantage of intrinsic smIg affinity. Second, in the young New Zealand Black animal …
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Polypyrrole Modified with Macrocycles for the Detection of Aqueous Pollutants and Carbon Membranes for the Separation of Gases
… (CV), differential pulse voltammetry (DPV) and constant potential amperometry (CPA) were the techniques employed to evaluate the sensitivity of PPy/sul-bCD and PPy/sul-calix[4] towards the redox states of MV2+, MV+ and MV0 of paraquat. A limit of detection of 1.28 ´ 10-5 mol dm-3 and 3.48 ´ 10-6 …
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New insights into the binding site formation and the performance of molecularly imprinted polymers
… of binding sites (N) and the number average association constant (Kn) were calculated for each different percent template imprinted polymer using the continuous affinity distribution analysis (AD). The trends of N and Kn for the polymer provided evidence that the final binding site of a …
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Semiconductor nanostructures and nanoassemblies: a new perspective on their syntheses, properties and photophysical behaviour.
… whereas, CdSe formed a stable complex, with an association constant either larger than or comparable to previously reported values for other macrocycles. The QD : ligand ratio was determined by a number of independent experimental methods (UV, PL, NMR spectroscopy, quenching studies). The …
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Synthesis and evaluation of quadruple hydrogen-bonding modules for smart materials applications
… to complexation with DeUG results in a smaller association constant as compared to the DAN·DeUG system, which does not require reorganization prior to binding. The binding properties of the DAN·DeUG and bisuredionaphthyridine-DeUG units allow complexation induced control over the conformational …
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Saccharide recognition : boronic acids as receptors in polymeric networks
… and displacement assay (ARS) to enhance the association constant to saccharides at pH 7.4 • Enhancement of selectivity in polymeric systems by means of molecular imprinting using fructose as template and a polymerisable benzoboroxole as functional monomer for the recognition at pH 7.4 (Joined …
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Studies on a 50S Ribosomal Precursor Particle as a Substrate for <em>erm </em>E Methyltransferase Enzyme in <em>Staphylococcus aureus </em>.
… that <em>erm</em> methyltransferase has a lower association constant for the precursor particle compared to that of the erythromycin. This suggests that higher concentrations of erythromycin are needed to combat <em>erm</em> induced resistance.</p><p>These studies shed light on the interaction of …
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Study Of The Photodegradation And Photostability Of Anti-Cancer Drugs In Different Media Towards The Development Of Both New Actinometers And Liquid Formulations
… provides information on both stiochiometry and association constant of the complex. The results indicate that hydrophobic AXI forms a 1:0.8 complex, indicating the possibility of multiple association sites and/or different types of binding. The newly developed AXI/nanosponge liquid formulation …
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Biogenesis of iron-sulfur clusters and intracellular iron metabolism
… that IscA is capable of binding iron with an association constant of 3.0 x 10<sup>19</sup>M<sup>-1</sup>. In addition, iron-loaded IscA is capable of donating iron to the proposed scaffold IscU for nascent [Fe-S] cluster assembly. We show that hIscA, the human homolog of <i>E. coli</i> IscA, …
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