Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 58 for “"Association Analysis"”.
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Transcriptome-wide association analysis of survival in colorectal cancer patients
… decisions are currently made on the basis of associations made between groups of patients. Hence, there is a pressing need for new approaches for improved survival prediction that would allow tailoring of treatment interventions to individual patients who would most benefit, and also to …
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Genome-Wide Association Analysis of Major Depressive Disorder and Its Related Phenotypes.
… health problem. Recently several genome-wide association (GWA) studies of MDD have been reported; however, few GWA studies focus on the analysis for MDD related phenotypes such as neuroticism and age at onset of MDD. The purpose of this study is to determine risk factors for MDD, identify …
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Studies at the hemochromatosis (HFE) locus : gene conversions, haplotypes, and association analysis
Haplotype-based association studies offer an exciting potential methodology for the identification of genes that contribute to complex traits. There is thus great interest in understanding the biological forces that shape haplotypes. We have studied a well-characterized genetic locus surrounding …
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A genome-wide linkage scan and targeted family-based association analysis of dyslexia
… reported. The statistical methods of linkage and association were employed to investigate the genetic susceptibility for phonological coding dyslexia (PCD), a common form of dyslexia characterized by difficulties in single word decoding and resulting from deficits in phonological processing. A …
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Genetic diversity and candidate gene association analysis for growth in the South African Yellowtail (Seriola lalandi)
… in CRYBG1a, DRP2 and PXDN. A case-control association analysis was performed to detect and validate variants linked to growth. Furthermore, a quantitative analysis was conducted using weight, length and Fulton’s conditioning factor as continuous response variables to pinpoint SNPs …
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Association Analysis of Class II Division 2 Malocclusion and Two Genes Linked to Hypodontia (MSX1 and PAX9)
Purpose of the Study: Determine if there is an association of the CII/D2 malocclusion and genes linked to hypodontia, namely PAX9 and MSX1. Methods and Materials: One hundred probands with CII/D2 and one hundred non-CII/D2 with no hypodontia were enrolled in this study. Clinical exam, photographs, …
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Genome and epigenome wide association analysis identify new risk loci and reveals the role of ion channels in the development of childhood obesity Strong Kids 2 cohort
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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A vegetation survey of the Cape of Good Hope Nature Reserve
… Province of South Africa. The applicability of association-analysis to the distinctive fynbos vegetation found in the Mediterranean type climate of this region, was tested. Subjectively, two formations, Fynbos and Broad-leaved Scrub, were recognized. Fynbos was subdivided into two alliances, …
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The vegetation of the Cape Hangklip area
… suitability of homogeneity functions and of the association-analysis techniques for the analysis of large areas of the distinctive coastal and fynbos vegetation found in the Mediterranean type of climate in this region were investigated. Data were collected at 150 sampling sites of 10 x 5 metres …
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GENETIC DIVERSITY AND LINKAGE DISEQUILIBRIUM IN WILD SOYBEAN, LANDRACES, ANCESTRAL, AND ELITE SOYBEAN POPULATIONS
… may be best suited for fine mapping utilizing association analysis. The landraces do not contain much more variability than the elite cultivars but may have enough diversity to facilitate genetic improvement of elite cultivars. Finally, due to the extended levels of LD in the landraces and the …
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Mixture Model Approaches to Integrative Analysis of Multi-Omics Data and Spatially Correlated Genomic Data
<p>Integrative genomic data analysis is a powerful tool to study the complex biological processes behind a disease. Statistical methods can model the interrelationships of the involved gene activities through jointly analyzing multiple types of genomic data from different platforms (vertical …
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High Dimensional Analysis of Genetic Data for the Classification of Type 2 Diabetes Using Advanced Machine Learning Algorithms
… of identified candidate genes. Genome-wide association studies (GWAS) have enhanced our understanding of genetic-based determinants in common complex human diseases. To date, 120 single nucleotide polymorphisms (SNPs) for T2D have been identified using GWAS. Standard statistical tests for …
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DESIGN AND IMPLEMENTATION OF A CO-LOCATION ANALYSIS TOOL
… co-location patterns has been a research area in association analysis for several years. In this thesis, we designed and implemented a user-friendly, interactive Co-location Analysis Tool which can be used to extract co-location patterns from spatial datasets. By using this tool, we are able to …
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Molecular characterization of ovine GM1 gangliosidosis
… animals were genotyped and a genome wide association analysis was performed using PLINK. A significant association was detected for multiple SNPs on OAR19; further investigation showed this area was orthologous to HSA3 containing GLB1. Sequence analysis revealed a G to T nucleotide …
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Mapping of monogenic and quantitative trait loci using a whole genome scan approach and single nucleotide polymorphism platforms
… that affects Hereford cattle. A whole-genome association analysis was conducted using BovineSNP50 BeadChip to map the hypotrichosis locus to a chromosomal region. Significant association was detected between the hypotrichosis phenotype and a locus on bovine chromosome 5 (BTA5) and homozygosity …
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Introducing A Novel Method For Genetic Analysis of Autism Spectrum Disorder
… I first review previous studies on genetic association analyses of autism spectrum disorder. A large number of these studies fall into two categories: Genome Wide Association Studies (GWAS) and sequencing studies. Although GWAS are able to identify multiple common risk variants associated …
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Studies on the macroinvertebrate bottom fauna of the Irwell, a polluted river
… zinc is the least toxic.Data obtained from analysis of bi-monthly samples of riffle benthos from ten sites on the river show the fauna to be dominated by Oligochaeta, notably Limnodrilus hoffmeisteri. Using simple association analysis the fauna is divisible into three 'ecological …
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Freud-1, a novel regulator of the dopamine D2 and serotonin 1A receptor genes
… that is associated with addictive disorders. Association analysis did not reveal an association of this polymorphism in patients with major depressive disorder or schizophrenia compared to normal subjects. In summary, I have identified Freud-1 as an important transcription factor involved in …
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